Human CD155 / PVR / NECL5 Protein (Fc Tag) 10109-H02H from Sino Biological, Inc.

Product Specs
ItemHuman CD155 / PVR / NECL5 Protein (Fc Tag)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number10109-H02H
Size100 µg
Conjugate/TagC-human IgG1-Fc
Purity≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human CD155/Fc is a disulfide-linked homodimer. The reduced monomer consists of 561 amino acids and predicts a molecular mass of 61.8 kDa. As a result of glycosylation, the rhCD155/Fc monomer migrates as approximately 95-105 kDa band in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NamePVR
Source/Expression SystemHEK293 Cells
NCBI Full Gene NamePVR cell adhesion molecule
NCBI Gene AliasesCD155, HVED, NECL5, Necl-5, PVS, TAGE4
Activity1.Immobilized Recombinant Human TIGIT / VSTM3 Protein (His Tag) (Cat:10917-H08H3) at 2 µg/mL (100 µl/well) can bind Recombinant Human CD155/PVR/NECL5 Protein (Fc Tag) (Cat:10109-H02H), the EC50 is 10-30 ng/mL. 2.Loaded Recombinant Human CD155/PVR Protein, hFc Tag (Cat. No. 10109-H02H) on ProA Biosensor, can bind Recombinant Human TIGIT Protein, His Tag (Cat. No. 10917-H08H3) with an affinity constant of 0.51 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 3.Loaded Recombinant Human CD155/PVR Protein, hFc Tag (Cat. No. 10109-H02H) on ProA Biosensor, can bind Recombinant Human DNAM-1/CD226 Protein, His Tag (Cat. No. 10565-H08H) with an affinity constant of 0.386 µM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 4.Recombinant Human CD155/PVR Protein, hFc Tag (Cat. No. 10109-H02H) captured on Protein A chip can bind Recombinant Human TIGIT Protein(Dimer), His Tag (Cat. No. 10917-H08H3) with an affinity constant of 3.28 nM as determined in an SPR assay (Biacore 8K) (Routinely tested)
FormatLyophilized from sterile 50mM Tris, 100mM NaCl, 100mM Arg, pH 7.5

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Enhancing anti-tumor immunity through co-blocking PD-L1 and TIGIT by facilitating tumor-directed responses and additional VEGF inhibitionFrontiers in ImmunologyJanuary 14, 2026Xi Zhu, Xiaopei Cui, Haijia Yu, Jingen Xu, Xiaofang Chen, Xiaochen Ren, Xiaoyue Wei, Shi Chen, Yangtin Wang, Liyang Fei, et al.lot: P2107890; 0.95 µg/mL final concentration) and co-treated with soluble CD155 (Sino Biological, Cat#10109-H02H; 8 µg/mL final concentration). Serially diluted antibodies (50 µL/well) were added, followed by incubation

(2) TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositisNat CommunMay 15, 2025Yimei Lai, Shuang Wang, Tingting Ren, Jia Shi, Yichao Qian, Shuyi Wang, Mianjing Zhou, Ryu Watanabe, Mengyuan Li, Xinyuan Ruan, et al.Alternatively, TIGIT was stimulated with recombinant human CD155-Fc chimera protein (Sino Biological, cat# 10109-H02H) plate-bound at 10 μg/ml. As an isotype control, we used IgG1 (Sigma, Cat# I5154). T-cell proliferation To

(3) Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activityFrontiers in ImmunologyNovember 1, 2023Alyson J. Smith, Robert E. Thurman, Weiping Zeng, Bryan Grogan, Sasha Lucas, Guadalupe Gutierrez, Ryan A. Heiser, Serena W. Wo, Amber Blackmarr, Scott Peterson, et al.Supplementary Materials and Methods. Blockade of CD155 and TIGIT interaction hCD155-Fc (Sino Biological 10109-H02H) and mCD155-Fc (Sino Biological 50259-M41H) were conjugated to Alexa Fluor 647 (Thermo Fisher). Cells

(4) COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockadeCancer immunology, immunotherapy : CIIDecember 1, 2021Hansen K, Kumar S, Logronio K, Whelan S, Qurashi S, Cheng HY, Drake A, Tang M, Wall P, Bernados D, et al.

(5) TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In VitroJournal of immunotherapy (Hagerstown, Md. : 1997)October 1, 2020Zhang C, Wang Y, Xun X, Wang S, Xiang X, Hu S, Cheng Q, Guo J, Li Z, Zhu J.

(6) TIGIT expression levels on CD4+ T cells are correlated with disease severity in patients with psoriasisClinical and experimental dermatologyAugust 1, 2018Wang FF, Wang Y, Wang L, Wang TS, Bai YP.

(7) The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functionsNature immunologyMay 1, 2014Chan CJ, Martinet L, Gilfillan S, Souza-Fonseca-Guimaraes F, Chow MT, Town L, Ritchie DS, Colonna M, Andrews DM, Smyth MJ.

(8) CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domainThe Journal of biological chemistryMarch 7, 2014Hou S, Ge K, Zheng X, Wei H, Sun R, Tian Z.

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Human CD155 / PVR / NECL5 Protein (Fc Tag)

Human CD155 / PVR / NECL5 Protein (Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

Citations (8)

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Human CD155 / PVR / NECL5 Protein (Fc Tag) from Sino Biological, Inc.

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