Human FCGRT & B2M Heterodimer Protein (His Tag) CT009-H08H from Sino Biological, Inc.

Product Specs
ItemHuman FCGRT & B2M Heterodimer Protein (His Tag)
CompanySino Biological, Inc.
Price $348.00Supplier Page View Company Product Page
Catalog NumberCT009-H08H
Activity1.Loaded Human FcRn recombinant protein (Cat. CT009-H08H) on His1K Biosensor, can bind Recombinant Human IgG1-Fc Protein (103 Cys/Ser) (Cat: 10702-HNAC) with an affinity constant of 0.11 µM as determined in a BLI assay (Sartorius Octet Red384) (Routinely tested). 2.Loaded Human FcRn recombinant protein (Cat. CT009-H08H) on His1k Biosensor, can bind Recombinant Human IgG4-Fc Protein (S108P) (Cat: 13505-HNAH) with an affinity constant of 0.08 µM as determined in a BLI assay (Sartorius Octet Red384) (Routinely tested). 3.Recombinant Human FCGRT & B2M Heterodimer Protein (His Tag) (Cat: CT009-H08H) captured on CM5 chip via Anti-His antibody, can bind Anti-VEGF (Research Grade Bevacizumab Biosimilar) with an affinity constant of 0.897 µM as determined in an SPR assay (Biacore T200) (QC tested). 4.Captured Human FcRn recombinant protein (Cat. CT009-H08H) on Anti-His Chip can bind Anti-PD1 (Research Grade Nivolumab Biosimilar) with an affinity constant of 0.23 µM as determined in an SPR assay (Biacore T200) (Routinely tested). 5.Loaded Recombinant Human FCGRT & B2M Heterodimer Protein, His Tag (Cat. No. CT009-H08H) on His1K Biosensor, can bind Anti-HER2 (Research Grade Trastuzumab Biosimilar) with an affinity constant of 11.1nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 6.Recombinant Human FCGRT & B2M Heterodimer Protein (His Tag) (Cat: CT009-H08H) captured on CM5 chip via Anti-His antibody, can bind Recombinant Human IgG1-Fc Protein (103 Cys/Ser) (Cat: 10702-HNAH) with an affinity constant of 0.932 µM as determined in an SPR assay (Biacore 8K) (Routinely tested). 7.Recombinant Human FCGRT & B2M Heterodimer Protein (His Tag) (Cat: CT009-H08H) captured on CM5 chip via Anti-His antibody, can bind Recombinant Human IgG3-Fc / IGHG3 Protein (Cat: 13906-HNAH) with an affinity constant of 1.590 µM as determined in an SPR assay (Biacore 8K) (Routinely tested). 8.Recombinant Human FCGRT & B2M Heterodimer Protein (His Tag) (Cat: CT009-H08H) captured on CM5 chip via Anti-His antibody, can bind Recombinant Human IgG4-Fc Protein (S108P) (Cat: 13505-HNAH) with an affinity constant of 0.350 µM as determined in an SPR assay (Biacore 8K) (Routinely tested). 9.Recombinant Human FCGRT & B2M Heterodimer Protein (His Tag) (Cat: CT009-H08H) captured on CM5 chip via Anti-His antibody, can bind Recombinant Human IgG2-Fc Protein (257 Ser/Ala) (Cat: 13504-HNAH) with an affinity constant of 0.932 µM as determined in an SPR assay (Biacore 8K) (Routinely tested)
Size100 µg
FormatLyophilized from sterile PBS, pH 7.4
NCBI Gene AliasesFCRN, alpha-chain, IMD43, FcgammaRn
NCBI Full Gene Namebeta-2-microglobulin, Fc gamma receptor and transporter
Source/Expression SystemHEK293 Cells
Molecule NameFCGRT & B2M
SpeciesHuman
Molecular WeightThe recombinant heterodimer of human FCGRT/B2M comprises 384 (285+99) amino acids and has a calculated molecular mass of 43.5 (31.8+11.7) kDa. The apparent molecular mass of human FCGRT/B2M heterodimer is approximately 35 & 12 kDa respectively in SDS-PAGE under reducing conditions. The molecular weight of this protein is around 45-53 kDa verified by SEC-MALS (Routinely tested)
TypeRecombinant protein
Purity≥ 95 % as determined by SDS-PAGE, ≥ 90 % as determined by SEC-HPLC, ≥ 90% as determined by SEC-MALS(Routinely tested)
Conjugate/TagC-His

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Development and preclinical characterization of AMG 329: a human antibody neutralizing FLT3 ligandmAbsDecember 1, 2025Lau-Kilby A, Gunsior M, Bartczak A, Chyou S, Hester J, Sims D, Xiao X, Pavlik P, Chen Y, Casey KA, et al.FcγRI and steady-state binding for low-affinity FcγR. For FcRn analyses, human FcRn (Sino Biological #CT009-H08H) was coupled onto a Series S CM5 (carboxymethylated dextran) sensor chip (Cytiva) at 10 μg/mL in sodium

(2) Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cellsPLoS pathogensJuly 1, 2025Aguilera-Flores C, Valencia-Morales MDP, López T, Moreno-Contreras J, Lentz A, Espinoza MA, DuBois RM, López S, Arias CF.was incubated with 8.3 μg/ml of recombinant human FCGRT & B2M heterodimer protein (SinoBiological #CT009-H08H) for 1h at 37°C. The mix was then used to infect 100% confluent CaCo-2 monolayers grown in 24-well plates

(3) Engineering IgG antibodies for intracellular targeting and drug deliveryJournal of controlled release : official journal of the Controlled Release SocietyJune 10, 2025Kim DS, Kim SE, Byeon JS, Lee HJ, Kim JW, Kim H, Chae BH, Ko DH, Lee SG, Yoon SR, et al.

(4) An antibody against human interleukin-2 showing minimal binding to neonatal Fc receptor: Potent anti-tumor activity and reduced systemic toxicity in miceEuropean journal of pharmacologyJanuary 15, 2025Lv Y, Chen J, Wang C, Jin Z, Lou J.

(5) Preclinical investigations and a first-in-human phase 1a trial of JS007, a novel anti-CTLA-4 antibody, in patients with advanced solid tumorsExperimental hematology & oncologyOctober 1, 2024Zhou C, Jiang J, Xiang X, Liu H, Wu G, Zeng R, Lu T, Zhang M, Shen Y, Hong M, et al.(Sino Biological, 10734-H08C), FcγRI (CD64) (Sino Biological, 10256-H08S), and FcRn (Sino Biological, CT009-H08H). The test antibody was then gradient-diluted, and binding signals were detected. Direct cytotoxicity

(6) A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector FunctionBiochemistryApril 16, 2024Zhou F, Ben Y, Jiang H, Tan S, Mu G, Zha Z, Dong S, Huang S, Zhou Y, Jin Y, et al.dissociation step in KB for 240 s. Binding to the human neonatal Fc receptor (FcRn, Sino Biological, #CT009-H08H) was measured as described above except for adjusting the pH of KB to 6.0. Moreover, one sensor associated

(7) Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickensCommunications biologyJune 1, 2023Park JS, Choi HJ, Jung KM, Lee KY, Shim JH, Park KJ, Kim YM, Han JY.Sino Biological Inc, Beijing, China (FcγRIA-10256-H08H; FcγRIIA 167 Arg-10374-H08H; FcγRIIIA F176V-10389-H08H1; FcRn-CT009-H08H; DC-SIGN-10200-H01H). rhIgG1 Fc was purified from juvenile ALB::hIgG1 Fc chicken serum. SPR analysis

(8) ZRC3308 Monoclonal Antibody Cocktail Shows Protective Efficacy in Syrian Hamsters against SARS-CoV-2 InfectionVirusesDecember 3, 2021Yadav PD, Mendiratta SK, Mohandas S, Singh AK, Abraham P, Shete A, Bandyopadhyay S, Kumar S, Parikh A, Kalita P, et al.

(9) Fc-Independent Protection from SARS-CoV-2 Infection by Recombinant Human Monoclonal AntibodiesAntibodies (Basel, Switzerland)November 8, 2021Noy-Porat T, Edri A, Alcalay R, Makdasi E, Gur D, Aftalion M, Evgy Y, Beth-Din A, Levy Y, Epstein E, et al.then washed. Sensors were then incubated with different concentrations of FcRn (Sino Biological, No. CT009-H08H; ranging from 75 to 300 nM) in pH 6.0, for 60 s (association phase) and transferred to buffer-containing

(10) Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibodyNature communicationsFebruary 11, 2021Rosenfeld R, Noy-Porat T, Mechaly A, Makdasi E, Levy Y, Alcalay R, Falach R, Aftalion M, Epstein E, Gur D, et al.and then washed. Sensors were then incubated with different concentrations of FcRn (Sino Biological #CT009-H08H; ranging from 75 to 300 nM) in pH 6.0, for 60 s (association phase) and transferred to buffer-containing

(11) Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoformsmAbsFebruary 1, 2019Wada R, Matsui M, Kawasaki N.heterodimer of human FCGRT/B2M with one putative N-glycosylation site on FCGRT (Sino Biological, Cat # CT009-H08H, UniProt accession number P55899). For interaction analysis of immobilized FcRn and IgG1 mAb glycoforms,

(12) Toward a Combinatorial Approach for the Prediction of IgG Half-Life and ClearanceDrug metabolism and disposition: the biological fate of chemicalsDecember 1, 2018Goulet DR, Watson MJ, Tam SH, Zwolak A, Chiu ML, Atkins WM, Nath A.

(13) Distribution of FcRn Across Species and TissuesThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyJune 1, 2017Latvala S, Jacobsen B, Otteneder MB, Herrmann A, Kronenberg S.primate and rodent recombinant FcRn-B2M heterodimer proteins purchased from Sino Biological (human: CT009-H08H, cynomolgus monkey: CT031C08H, wild-type mouse: CT029-M08H, and rat: CT030-R08H; Sino Biological, Inc.,

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Human FCGRT & B2M Heterodimer Protein (His Tag)

Human FCGRT & B2M Heterodimer Protein (His Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human FCGRT & B2M Heterodimer Protein (His Tag) from Sino Biological, Inc.

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