Human TREM2 Protein (ECD,His Tag) 11084-H08H from Sino Biological, Inc.

Product Specs
ItemHuman TREM2 Protein (ECD,His Tag)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number11084-H08H
FormatLyophilized from sterile PBS, pH 7.4
Size100 µg
NCBI Gene AliasesPLOSL2, TREM-2, Trem2a, Trem2b, Trem2c
NCBI Full Gene Nametriggering receptor expressed on myeloid cells 2
Source/Expression SystemHEK293 Cells
Molecule NameTREM2
SpeciesHuman
Molecular WeightThe secreted recombinant human TREM2 comprises 167 amino acids with a predicted molecular mass of 18.9 kDa. As a result of glycosylation, the apparent molecular mass of rhTREM2 is approximately 30-40 kDa band in SDS-PAGE under reducing conditions
TypeRecombinant protein
Purity≥ 90 % as determined by SDS-PAGE
Conjugate/TagC-His

Add to Compare List

Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterizationEuropean Journal of Medicinal ChemistryJanuary 15, 2026Hossam Nada, Shaoren Yuan, Farida El Gaamouch, Sungwoo Cho, Katarzyna Kuncewicz, Laura Calvo-Barreiro, Moustafa T. Gabrprotein capture experiment was conducted to ensure stable immobilization of the TREM2 protein (Cat. # 11084-H08H, Sino Biological, Beijing, China) onto the affinity matrix. Based on this preliminary assessment, the

(2) TREM2 hit discovery using temperature-related intensity change (TRIC) technology: A proof-of-concept high-throughput screening approachSLAS DiscoverySeptember 1, 2025Natalie Fuchs, Katarzyna Kuncewicz, Farida El El Gaamouch, Moustafa T. Gabr10 mM DMSO stocks on 384-well plates. His-tagged TREM2 (extracellular domain (ECD), SinoBiological, #11084-H08H) was labeled with RED-tris-NTA 2nd generation dye (NanoTemper, #MO-L018) according to the manufacturer’s

(3) PET imaging of TREM2 in amyloid-beta induced neuroinflammationEuropean Journal of Nuclear Medicine and Molecular ImagingMay 28, 2025Amelia D Dahlén, Sahar Roshanbin, Ximena Aguilar, Nadja M Bucher, Sara Lopes van den Broek, Dag Sehlin, Stina Syvänenµg/mL, SinoBiological, 158–50149-M02H-100) and human TREM2 protein (0.5 µg/mL, SinoBiological, 158–11084-H08H-100). Plates were incubated overnight at 4 °C. Following incubation, the plates were blocked with 1%

(4) Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depressionBrain, behavior, and immunityAugust 1, 2024Reichert Plaska C, Heslegrave A, Bruno D, Ramos-Cejudo J, Han Lee S, Osorio R, Imbimbo BP, Zetterberg H, Blennow K, Pomara N.standard curve constructed from recombinant human TREM2 protein (4000 −62.5pg/ml Sino Biological Inc 11084-H08H) diluted in assay buffer (0.25% BSA and 0.05% Tween 20 in PBS (pH=7.4). Plates were again washed three

(5) Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathologyMolecular NeurodegenerationMay 18, 2024Rebecca L. Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A. Gifford, Kimberly R. Pechman, Mabel Seto, Vladislav A. Petyuk, Yanling Wang, et al.antibodies (R&D Systems BAF1828) were incubated with recombinant human TREM2 protein (Sino Biological Inc. 11084-H08H) and a SULFO-TAG–labeled anti-mouse secondary antibody was used for detection. More detailed kit information

(6) sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling PathwayBiologyJanuary 30, 2024Arsenault R, Marshall S, Salois P, Li Q, Zhang W.at 150,000 cells per well. Human soluble TREM2 (sTREM2 protein) (Sino Biological, Beijing, China, #11084-H08H; His-tagged, expressed, and purified from HEK293 cells) was purchased and reconstituted according to

(7) Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutationActa neuropathologicaJune 1, 2023Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, et al.(PBS). Freshly thawed supernatants and recombinant human TREM2 standard (SinoBiological, catalog no. 11084-H08H-50) were incubated in duplicate overnight at 4°C. For detection, a goat anti-human TREM2 biotinylated

(8) TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegenerationNature neuroscienceJanuary 1, 2022Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, et al.T200 instrument (GE Healthcare Life Sciences) at Creative biolab. hTREM2 protein (Sino Biological, 11084-H08H) was directly immobilized on the CM5 chip using an amine coupling kit (GE Healthcare Life Sciences).

(9) Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD micemAbsJanuary 1, 2022Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, Tong Q, Zhang N, An Z.protein purification system (Cytiva). Briefly, purified antibodies and human TREM2-His (Sino Biological, 11084-H08H) were mixed at a 2:1 ratio with the antibody at 1 mg/mL concentration. A total of 100 µl of the mixture

(10) Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomainStructure (London, England : 1993)November 4, 2021Szykowska A, Chen Y, Smith TB, Preger C, Yang J, Qian D, Mukhopadhyay SM, Wigren E, Neame SJ, Gräslund S, et al.appropriate dilution in DMEM + 1% BSA alongside a standard curve with TREM2 peptide (SinoBiological, 11084-H08H) and incubated for 2 h, at RT. 25 μL of the biotinylated detection antibody (R&D, BAF1828) at 1.5 μg/mL

(11) Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk regionEMBO molecular medicineApril 7, 2020Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, et al.

(12) Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tauBrain : a journal of neurologyMarch 1, 2020Wilson EN, Swarovski MS, Linortner P, Shahid M, Zuckerman AJ, Wang Q, Channappa D, Minhas PS, Mhatre SD, Plowey ED, et al.

(13) Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal FluidJournal of Alzheimer's disease : JADJanuary 1, 2020Rauchmann BS, Sadlon A, Perneczky R, Alzheimer’s Disease Neuroimaging Initiative..

(14) Cerebrospinal Fluid Biomarkers in Cerebral Amyloid AngiopathyJournal of Alzheimer's disease : JADJanuary 1, 2020Banerjee G, Ambler G, Keshavan A, Paterson RW, Foiani MS, Toombs J, Heslegrave A, Dickson JC, Fraioli F, Groves AM, et al.temperature with 50μL per well of either the standard curve constructed from recombinant human TREM2 protein (11084-H08H-50, Sino Biological Inc., Beijing, China) diluted in assay buffer (0.25% BSA and 0.05% Tween 20 in PBS;

(15) Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriersAlzheimer's research & therapyNovember 28, 2019Ashton NJ, Suárez-Calvet M, Heslegrave A, Hye A, Razquin C, Pastor P, Sanchez-Valle R, Molinuevo JL, Visser PJ, Blennow K, et al.

(16) Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasmaExperimental gerontologyJuly 1, 2019Jensen CS, Bahl JM, Østergaard LB, Høgh P, Wermuth L, Heslegrave A, Zetterberg H, Heegaard NHH, Hasselbalch SG, Simonsen AH.

(17) CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuumNeurobiology of agingFebruary 1, 2019Rauchmann BS, Schneider-Axmann T, Alexopoulos P, Perneczky R, Alzheimer's Disease Neuroimaging Initiative..

(18) Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegenerationAlzheimer's & dementia : the journal of the Alzheimer's AssociationSeptember 1, 2018Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, et al.

(19) Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroupAlzheimer's research & therapyAugust 16, 2018Woollacott IOC, Nicholas JM, Heslegrave A, Heller C, Foiani MS, Dick KM, Russell LL, Paterson RW, Keshavan A, Fox NC, et al.with 50 μl per well of either (1) the standard curve constructed from recombinant human TREM2 protein (11084-H08H-50; Sino Biological Inc., Beijing, China) diluted in assay buffer (0.25% BSA and 0.05% Tween 20 in PBS,

(20) The novel KLF4/PLAC8 signaling pathway regulates lung cancer growthCell death & diseaseMay 22, 2018Jia Y, Ying X, Zhou J, Chen Y, Luo X, Xie S, Wang QC, Hu W, Wang L.

Be the First to Write a Review!

Human TREM2 Protein (ECD,His Tag)

Human TREM2 Protein (ECD,His Tag) from Sino Biological, Inc.

Description

Sino Biological, Inc.

Citations (24)

Reviews

Human TREM2 Protein (ECD,His Tag) from Sino Biological, Inc.

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map