Mouse Noggin / NOG Protein (Fc Tag) 50688-M02H from Sino Biological, Inc.

Product Specs
ItemMouse Noggin / NOG Protein (Fc Tag)
CompanySino Biological, Inc.
Price $138.00Supplier Page View Company Product Page
Catalog Number50688-M02H
Conjugate/TagC-human IgG1-Fc
Purity> 85 % as determined by SDS-PAGE
TypeRecombinant protein
Molecular WeightThe recombinant mouse NOG/Fc comprises 454 amino acids and has a predicted molecular mass of 51 kDa. It migrates as approximately 60 kDa band in SDS-PAGE under reducing conditions
SpeciesMouse
Molecule NameNOG
Source/Expression SystemHEK293 Cells
NCBI Full Gene Namenoggin
Activity1.Measured by its ability to inhibit BMP4-induced alkaline phosphatase production by MC3T3-E1 cells. The ED50 for this effect is typically 0.1-0.6µg/mL. 2.Human intestinal cancer organoids were cultured with RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 3.Human colorectum organoids were cultured with RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 4.Human lung cancer organoids were cultured with FGF2(Cat#10014-HNAE), FGF4(Cat#16043-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 5.Human lung organoids were cultured with FGF2(Cat#10014-HNAE), FGF4(Cat#16043-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 6.Human cholangiocarcinomas organoids were cultured with FGF2(Cat#10014-HNAE), HGF(Cat#10463-HNAS), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 7.Human liver cancer organoids were cultured with FGF2(Cat#10014-HNAE), HGF(Cat#10463-HNAS), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), TGFB1(Cat#10804-HNAC), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 8.Human kidney cancer organoids were cultured with FGF2(Cat#10014-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 9.Human kidney organoids were cultured with FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS), HGF(Cat#10463-HNAS), FGF4(Cat#16043-HNAE). (Routinely tested). Data provided by D1 Medical Technology. 10.Human gastric cancer organoids were cultured with EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 11.Human stomach organoids organoids were cultured with EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 12.Human breast cancer organoids were cultured with FGF7(Cat#10210-H07E), RSPO1(Cat#11083-HNAS), IGF1(Cat#10598-HNAE), EGF(Cat#50482-MNCH), NRG1 Beta 1(Cat#11609-H01H), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 13.Human ovarian organoids were cultured with IGF1(Cat#10598-HNAE), NRG1 Beta 1(Cat#11609-H01H), RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 14.Human small intestinal organoids were cultured with IL22(Cat#13059-HNAE), FGF10(Cat#10573-HNAE), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology
FormatLyophilized from sterile PBS, pH7.4
Size20 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinomaCell Reports MedicineApril 21, 2026Youpei Lin, Lihua Peng, Haichao Zhao, Penghui Lin, Lv Chen, Zunyun Gong, Jian Lin, Dongbing Liu, Xupeng Yang, Xiangze Song, et al.(Sigma, A9165), 500 ng/mL R-spondin 1 (Sino Biological, 11083-HNAS), 25 ng/mL Noggin (Sino Biological, 50688-M02H), 10 mM nicotinamide (Sigma, N0636), 10 nM Gastrin (Sigma, G9145), 50 ng/mL recombinant human EGF (Peprotech,

(2) Comprehensive dissection of rectal cancer organoids in responses to chemoradiationCell Reports MedicineOctober 21, 2025Xiaoya Xu, Tao Lv, Ye Yao, Juefeng Wan, Lijun Shen, Fan Xia, Xiaoxue Gao, Yuanchuang Li, Guoxiang Fu, Yun Deng, et al.DMEM/F12,Gibco,Cat# 12634-010 R-spondin 1,Sino Biological,Cat# 11083-HNAS Noggin,Sino Biological,Cat# 50688-M02H R-spondin 1,EnaMab,Cat# ERSP1000 Noggin,EnaMab,Cat# ENGG0100 Wnt3a,EnaMab,Cat# EWNT0100 EGF,Sino Biological

(3) AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel diseaseiScienceJuly 18, 2025Liying Lu, Keying Xu, Huiheng Qu, Lele Song, Yanan Song, Yanjun Wu, Xia Sun, Jingwen Kong, Qian Wen, Jiazheng Jiao, et al.protein,Sino Biological,Cat#11083-HNAS Recombinant Mouse Noggin/NOG protein (hFc Tag),Sino Biological,Cat#50688-M02H Recombinant Mouse EGF protein,Sino Biological,Cat#50482-MNCH Y27632,Sigma,Cat#Y0503 Ionomycin,MCE,Cat#HY-13434 Phorbol 12-myristate 13-acetate

(4) Precision Medicine: IL-1RA and Pancreatic Cancer OrganoidsBiology (Basel)May 25, 2025Annah G. Morgan, Michelle F. Griffin, Michael T. Longaker, Jeffrey A. NortonMouse Epidermal Growth Factor (Cat# 2028-EG-200; Bio-techne, Minneapolis, MN, USA), 100 ng/mL recombinant murine Noggin (Cat# 50688-M02H; SinoBiological, Beijing, China), and 10% v/v R-spondin1 conditioned medium (Cat# SCM104; Sigma-Aldrich).

(5) Characterizing the effects of triclosan and triclocarban on the intestinal epithelial homeostasis using small intestinal organoidsJournal of hazardous materialsNovember 5, 2024Cheng X, Shen H, Zhang W, Chen B, Xu S, Wu L.

(6) Telomere dysfunction alters intestinal stem cell dynamics to promote cancerDevelopmental CellJune 1, 2024Kyle A. LaBella, Wen-Hao Hsu, Jiexi Li, Yutao Qi, Yonghong Liu, Jingjing Liu, Chia-Chin Wu, Yang Liu, Zingzhi Song, Yiyun Lin, et al.E1383 Nutlin-3a,Cayman Chemical,Cat# 10004372-1 Trypsin,Gibco,Cat# 25300054 Noggin,SinoBiological,Cat# 50688-M02H Nocodazole,Sigma,Cat# SML1665 ,, Critical commercial assays,Critical commercial assays,Critical commercial

(7) Unveiling Epigenetic Vulnerabilities in Triple-Negative Breast Cancer through 3D Organoid Drug ScreeningPharmaceuticals (Basel, Switzerland)February 8, 2024Rao X, Qiao Z, Yang Y, Deng Y, Zhang Z, Yu X, Guo X.alternatives: 250 ng/mL Rspo1 (#11083-HNAS; Sino Biological Inc., Beijing, China) and 100 ng/mL Noggin (#50688-M02H; Sino Biological Inc.). Additionally, we adjusted the concentration of SB 202190 to 500 nM (#S7067,

(8) Feedback activation of EGFR/wild-type RAS signaling axis limits KRAS(G12D) inhibitor efficacy in KRAS(G12D)-mutated colorectal cancerOncogeneMay 1, 2023Feng J, Hu Z, Xia X, Liu X, Lian Z, Wang H, Wang L, Wang C, Zhang X, Pang X.2 mM Glutamine, 50 mg/mL R-spondin-1 (11083-HNAS, Sino Biological, Houston, USA), 100 ng/mL Noggin (50688-M02H, Sino Biological), 1 × B27 supplement (17504-044, Invitrogen, Waltham, USA), 1.25 mM N-acetyl-cysteine

(9) Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation InjuryCell transplantationJanuary 1, 2023Guan R, Pan M, Xu X, Du L, Rao X, Fu G, Lv T, Zhang L, Li Y, Tang P, et al.(Corning, 356231; Glendale, AZ, USA) and cultured in standard organoid media containing Noggin (100 ng/mL, 50688-M02H; Sino Biological Inc., Beijing, China), R-spondin1 (500 ng/mL, 11083-HNAS; Sino Biological Inc., Beijing,

(10) Patient-Derived Organoid Model in the Prediction of Chemotherapeutic Drug Response in Colorectal CancerACS biomaterials science & engineeringAugust 8, 2022Hao M, Cao Z, Wang Z, Xin J, Kong B, Xu J, Zhang L, Chen P.

(11) Molecular Biomarker of Drug Resistance Developed From Patient-Derived Organoids Predicts Survival of Colorectal Cancer PatientsFrontiers in OncologyMarch 29, 2022Lifeng Chen, Bo Tian, Wen Liu, Haitao Liang, Yong You, Weizhen Liu17504-044), 500 ng/ml R-spondin 1 (Sino Biological Inc., 11083-HNAS), 100 ng/ml Noggin (Sino Biological Inc., 50688-M02H), 50 ng/ml epidermal growth factor (EGF) (Sino Biological Inc., 50482-MNCH), 1 mM n-Acetylcysteine (Sigma-Aldrich,

(12) Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem CellsStem cell reportsJanuary 12, 2021Li Y, Rao X, Tang P, Chen S, Guo Q, Fu G, Pan M, Liang L, Yao Y, Gao X, et al.(Sigma-Aldrich, A9165), 50 ng/mL EGF (Sino Biological, 50482-MNCH), 100 ng/mL Noggin (Sino Biological, 50688-M02H), and 500 ng/mL R-spondin1 (Sino Biological, 11083-HNAS). Organoids were monitored and imaged under

(13) Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in miceAmerican journal of translational researchJanuary 1, 2019Guo Q, Chen S, Rao X, Li Y, Pan M, Fu G, Yao Y, Gao X, Tang P, Zhou Y, et al.

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Organoid Technology in Drug Discovery
March 21, 2024
High-quality products are essential to culture, manipulate, and characterize these complex multicellular model systems read more

Mouse Noggin / NOG Protein (Fc Tag)

Mouse Noggin / NOG Protein (Fc Tag)

Mouse Noggin / NOG Protein (Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Mouse Noggin / NOG Protein (Fc Tag) from Sino Biological, Inc.

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