Human CTLA-4 / CD152 Protein 11159-HNAH from Sino Biological, Inc.

Product Specs
ItemHuman CTLA-4 / CD152 Protein
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number11159-HNAH
Conjugate/TagUnconjugated
Purity≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human CTLA4 consists of 126 amino acids and predicts a molecular mass of 13.5 kDa
SpeciesHuman
Molecule NameCTLA4
Source/Expression SystemHEK293 Cells
NCBI Full Gene Namecytotoxic T-lymphocyte associated protein 4
NCBI Gene AliasesALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
FormatLyophilized from sterile PBS, pH 7.4
Activity1.Measured by its binding ability in a functional ELISA. Immobilized CTLA-4 Protein, Human, Recombinant (Cat:11159-HNAH) at 2 µg/mL (100 µL/well) can bind B7-1 Protein, Human, Recombinant (His & hFc Tag), Biotinylated, the EC50 of B7-1 is 6-27 ng/mL. 2.Immobilized Recombinant Human CTLA-4 / CD152 Protein (Cat: 11159-HNAH) at 2 µg/mL (100 µL/well) can bind Anti-CTLA4(BMS) Antibody, Human IgG1, the EC50 is 2.5-7.5 ng/mL (Routinely tested). 3.Loaded Recombinant Human B7-1/CD80 Protein, hFc Tag (Cat. No. 10698-H02H) on ProA Biosensor, can bind Recombinant Human CTLA-4 Protein (Cat. No. 11159-HNAH) with an affinity constant of 2.09 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 4.Loaded Recombinant Human B7-2/CD86 Protein, hFc Tag (Cat. No. 10699-H02H) on ProA Biosensor, can bind Recombinant Human CTLA-4 Protein (Cat. No. 11159-HNAH) with an affinity constant of 5.17 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested)
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Discovery and characterization of two anti-PD-1 antibodies with a unique binding mechanism to human PD-1mAbsDecember 31, 2025Keyla María Gómez Castellano, Alejandra Montes Luna, Gregorio de Jesús Carballo Uicab, Frida Daniela Ramírez Villedas, Luis Javier Elizarrarás Rodríguez, Said Kayum Vázquez Leyva, Stefany Daniela Rodríguez Luna, Edith González González, María Martha Pedraza Escalona, Ben Holland, et al.ng/well of recombinant human CD28 (Sino Biological Cat. No. 11524-HCCH), CTLA-4 (Sino Biological Cat. No. 11159-HNAH) or ICOS (Sino Biological Cat. No. 11559-H08H). Coated wells were washed with PBST and blocked with

(2) Preclinical imaging evaluation of a bispecific antibody targeting hPD1/CTLA4 using humanized miceBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJune 1, 2024Hou X, Liu S, Zeng Z, Wang Z, Ding J, Chen Y, Gao X, Wang J, Xiao G, Li B, et al.

(3) FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor MicroenvironmentCancer immunology researchMarch 4, 2024Knorr DA, Blanchard L, Leidner RS, Jensen SM, Meng R, Jones A, Ballesteros-Merino C, Bell RB, Baez M, Marino A, et al.determined by ELISA using recombinant human B7.1 (#10698-HCCH, Sino Biological), recombinant human CTLA-4 (#11159-HNAH, Sino Biological), and recombinant human FcγRs (human FCGR2A #10374-H08H, human FCGR2B #10259-H08H,

(4) FcyRIIB is a novel immune checkpoint in the tumor microenvironment limiting activity of Treg-targeting antibodiesbioRxivJuly 4, 2023David Knorr, Rom Leidner, Shawn Jensen, Ryan Meng, Andrew Jones, Carmen Ballesteros-Merino, R. Bryan Bell, Maria Baez, David Sprott, Carlo Bifulco, et al.by ELISA using recombinant human B7.1 (Sino Biological, #10698-HCCH), human CTLA-4 (Sino Biological, 11159-HNAH), and human FcyRs (human FCGR2A #10374-H08H, human FCGR2B #10259-H08H, human FCGR3A #10389-H08H, Sino Biological

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Human CTLA-4 / CD152 Protein

Human CTLA-4 / CD152 Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Human CTLA-4 / CD152 Protein from Sino Biological, Inc.

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