Human PD1 / PDCD1 Protein (His & Fc Tag) 10377-H03H from Sino Biological, Inc.

Product Specs
ItemHuman PD1 / PDCD1 Protein (His & Fc Tag)
CompanySino Biological, Inc.
Price $178.00Supplier Page View Company Product Page
Catalog Number10377-H03H
Conjugate/TagC-human IgG1-Fc, His
Purity≥ 97 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human PD1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 390 amino acids and has a calculated molecular mass of 43.84 kDa. As a result of glycosylation, human PD1/Fc monomer migrates as an approximately 55-66 kDa protein in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NamePDCD1
Source/Expression SystemHEK293 Cells
NCBI Full Gene Nameprogrammed cell death 1
NCBI Gene AliasesCD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Activity1.Immobilized Anti-PD1(Research grade Nivolumab biosimilar) at 2 µg/mL (100 µL/well) can bind Recombinant Human PD1 / PDCD1 Protein (His & Fc Tag)(Cat: 10377-H03H), the EC50 is 1-4 ng/mL (QC tested). 2.Immobilized Recombinant Human PD1 / PDCD1 Protein (His & Fc Tag) (Cat: 10377-H03H) at 2 µg/mL (100 µL/well) can bind Recombinant Human PD-L2 Protein (Fc & AVI Tag), Biotinylated (Cat: 10292-H41H-B), the EC50 is 2.1 ng/mL (Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
Size50 µg

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Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

(2) Programmed Cell Death Protein 1/Programmed Cell Death Ligand-1 Axis activates Intracellular ERK Signaling in Tumor Cells to Mediate Poor Prognosis in T-cell LymphomaJournal of CancerJanuary 1, 2021Li Y, Fei Y, Liu L, Song Z, Meng X, Qiu L, Li L, Qian Z, Zhou S, Ren X, et al.western blotting similar to our previous study 15. After stimulating TCL cell lines with PD-1/Fc polypeptide (#10377-H03H, Sino Biological, Inc., USA), the levels of ERK and p-ERK were also measured using western blotting. The

(3) Preclinical characterization of Sintilimab, a fully human anti-PD-1 therapeutic monoclonal antibody for cancerAntibody TherapeuticsSeptember 17, 2018Shuang Zhang et al.Sintilimab in cynomolgus monkey serum. The capture agent was recombinant human PD-1 (Sino Biological Inc.; 10377-H03H), coated onto 96-well ELISA plates. Following overnight incubation, plates were blocked followed by

(4) Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1/PD-L1 axis activating intracellular AKT/mTOR pathway in tumor cellsOncotargetMay 31, 2016Ling Dong et al.PD-1/FC All five cell lines were cultured in complete medium containing 100ug/ml human recombinant PD1/Fc (10377-H03H, Sino Biological Inc., Beijing, China) for 24h and 48h. And then total proteins were isolated and run

Human PD1 / PDCD1 Protein (His & Fc Tag)