Human IL6ST / gp130 / CD130 Protein (His & Fc Tag) 10974-H03H from Sino Biological, Inc.

Product Specs
ItemHuman IL6ST / gp130 / CD130 Protein (His & Fc Tag)
CompanySino Biological, Inc.
Price $118.00Supplier Page View Company Product Page
Catalog Number10974-H03H
ActivityMeasured by its ability to inhibit the IL-6Rα enhancement of IL-6 activity on M1 mouse myeloid leukemia cell. The ED50 for this effect is typically 0.2-0.8 µg/mL in the presence of 50 ng/mL recombinant human IL-6sR and 100 ng/mL recombinant human IL-6
FormatLyophilized from sterile PBS, pH 7.4
Size20 µg
NCBI Gene AliasesCD130, CDW130, GP130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, STWS2, sGP130
NCBI Full Gene Nameinterleukin 6 cytokine family signal transducer
Source/Expression SystemHEK293 Cells
Molecule NameIL6ST
SpeciesHuman
Molecular WeightThe recombinant human IL6ST/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 844 amino acids and has a predicted molecular mass of 96 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IL6ST/Fc monomer is approximately 125-140 kDa due to glycosylation
TypeRecombinant protein
Purity≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC
Conjugate/TagC-human IgG1-Fc, His

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Site-specific dimerization of interleukin-11 alleviates bleomycin-induced pulmonary fibrosis in miceEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesJanuary 1, 2025Wang S, Wang P, Song X, Ma X, Wei L, Zheng Y, Yu R, Zhang C.

(2) Blocking GP130 binding in interleukin-11 through site-specific PEGylation attenuates bleomycin-induced pulmonary fibrosis in miceInternational journal of pharmaceuticsDecember 25, 2024Wang S, Wang P, Zhang M, Song X, Wei L, Ma X, Yao X, Zhang S, Chen Z, Zheng Y, et al.

(3) An engineered interleukin-11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinomaBioengineering & translational medicineNovember 1, 2023McIntosh BJ, Hartmann GG, Yamada-Hunter SA, Liu P, Williams CF, Sage J, Cochran JR.the previous section with the following conditions: 100 nM IL‐11R and 5 nM gp130‐Fc (Sino Biological, 10974‐H03H‐20) for Sort 3.1; 100 nM IL‐11R and 10 nM gp130‐Fc for Sort 3.2; 1 nM IL‐11R for Sort 3.3; 100 nM IL‐11R

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Human IL6ST / gp130 / CD130 Protein (His & Fc Tag)

Human IL6ST / gp130 / CD130 Protein (His & Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

Citations (3)

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Human IL6ST / gp130 / CD130 Protein (His & Fc Tag) from Sino Biological, Inc.

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