Human CD32a / FCGR2A Protein (167 His, His Tag) 10374-H08H1 from Sino Biological, Inc.

Product Specs
ItemHuman CD32a / FCGR2A Protein (167 His, His Tag)
CompanySino Biological, Inc.
Price $2,148.00Supplier Page View Company Product Page
Catalog Number10374-H08H1
Conjugate/TagC-His
Purity> 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human FCGR2A consists of 196 amino acids after removal of the signal peptide and predicts a molecular mass of 22 KDa. It migrates as an approximately 30 KDa protein due to glycosylation by SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameFCGR2A
Source/Expression SystemHEK293 Cells
Activity1. Loaded anti-CD20(Research grade Rituximab Biosimilar) on ProA Biosensor, can bind Recombinant Human CD32a / FCGR2A Protein (H167, His Tag) (Cat: 10374-H08H1) with an affinity constant of 1.7 µM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 2. Loaded Recombinant Human CD32a / FCGR2A Protein (H167, His Tag) (Cat: 10374-H08H1) on His1K Biosensor, can bind anti-VEGFA(Research grade Bevacizumab Biosimilar) with an affinity constant of 0.55 µM as determined in BLI assay (Sartorius Octet RED384) (QC tested). 3. Loaded Recombinant Human CD32a / FCGR2A Protein (H167, His Tag) (Cat: 10374-H08H1) on HIS1K Biosensor, can bind anti-CD20(Research grade Rituximab Biosimilar) with an affinity constant of 0.871 µM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 4. anti-VEGFA(Research grade Bevacizumab Biosimilar) captured on ProA chip, can bind Recombinant Human CD32a / FCGR2A Protein (H167, His Tag) (Cat: 10374-H08H1) with an affinity constant of 0.58 µM as determined in an SPR assay (Biacore T200) (Routinely tested). 5.Recombinant Human CD32a / FCGR2A Protein (167 His, His Tag) (Cat: 10374-H08H1) captured on CM5 chip via Anti-His antibody, can bind Nivolumab-Derived Anti-PD1 Antibody, Human IgG4 with an affinity constant of 9.184 µM as determined in an SPR assay (Biacore T200) (Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
Size1 mg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) A MERTK-Targeting Antibody-Drug Conjugate Selectively Depletes M2 Tumor-Associated Macrophages and MERTK-Expressing Cancer CellsCancer ResApril 15, 2026Shugaku Takeda, Subhasree Sridhar, Daniel Schefer, Celia Andreu-Agullo, Pui C. Lo, Minhee Lee, Robert Busby, David M. Darst, Anne Assmus, Suresh Anaganti, et al.(10389-H08H), FcgRIllA176val (10389-H08H1), FcgRIlIB (11046-H08H), FcgRIIA167Arg (10374-H08H), FcgRIlA167His (10374-H08H1), FcgRIIB (10259-H08H), FcgRI (10256-H08H). This assay was conducted by Abzena. Assessment of binding

(2) Non-Glycosylated, Legumain-Cleavable ISACs Drive Potent Anti-Tumor Immunotherapy via a Bystander EffectMolecular Cancer TherapeuticsApril 2, 2026Anqi Zhang, Mohan Reddy Mullapudi, Lina Wu, Michele Yi, Mohammad Asikur Rahman, Aiman A. Yaseen, H. Kayla Zhong, Tracy A. Brooks, L. Nathan Tumey#10256-H08S-100), CD16a (FcγRIIIa, Invitrogen, cat. #RP87975), and CD32a (FcγRIIa, Sino Biological, cat. #10374-H08H1-100). Binding assays were performed using a two-channel OpenSPR (or OpenSPR-XT) instrument (Nicoya Lifesciences)

(3) Nonglycosylated, Legumain-Cleavable ISACs Drive Potent Antitumor Immunotherapy via a Bystander EffectMol Cancer TherDecember 30, 2025Anqi Zhang, Mohan Reddy Mullapudi, Lina Wu, Michele Yi, Mohammad Asikur Rahman, Aiman A. Yaseen, H. Kayla Zhong, Tracy A. Brooks, L. Nathan Tumey#10256-H08S-100), CD16a (FcγRIIIa, Invitrogen, cat. #RP87975), and CD32a (FcγRIIa, Sino Biological, cat. #10374-H08H1-100). Binding assays were performed using a two-channel OpenSPR (or OpenSPR-XT) instrument (Nicoya Lifesciences)

(4) Human Fcγ-receptors selectively respond to C-reactive protein isoformsFrontiers in immunologyJanuary 1, 2025Henning A, Seer J, Zeller J, Peter K, Chen H, Thomé J, Kolb P, Eisenhardt SU, Hoffmann K, Hengel H.(Sino Biological, Bejing, China, recombinant, HEK293/ECD, C-terminal polyhistidine tag: 1038-H08H1/10374-H08H1/10374-H08H/10259-H08H/10256-H08H/10389-H08C) to immobilized pCRP (US Biological Life Sciences) or IgG

(5) Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptorsmAbsDecember 31, 2024Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra, Ian Wilkinson(CD32a) 131 R allele,human,Sino Biological,10374-H08H FcγRIIa (CD32a) 131 H allele,human,Sino Biological,10374-H08H1 FcγRIIb (CD32b),human,Sino Biological,10259-H08H FcγRIIIa (CD16a) 158F allele,human,Sino Biological,10389-H08H FcγRIIIa

(6) PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trialNPJ vaccinesJanuary 6, 2024Martinez FJ, White M, Guillotte-Blisnick M, Huon C, Boucharlat A, Agou F, England P, Popovici J, Hou MM, Silk SE, et al.receptor (FcγR) Ia (FcγRIa), FcγRIIa, FcγRIIb, and FcγRIIIa (all from Sino Biological: 10256-H08H, 10374-H08H1, 10259-H08H and 10389-H08H1, respectively) at dilutions 19 nM, 1.7 μM, 3.7 μM and 2.3 μM, respectively.

(7) Multivariate quantitative analysis of glycan impact on IgG1 effector functionsmAbsJanuary 1, 2024Cvijić T, Horvat M, Plahutnik J, Golob A, Marušič J.the extracellular domains of human FcγRIa (Cat. No. FCA-H52H2, AcroBioSystems), FcγRIIa131H (Cat. No. 10374-H08H1, Sino Biological), FcγRIIa131R (Cat. No. CDA-H5221, AcroBioSystems), FcγRIIb (Cat. No. CDB-H5228, AcroBioSystems),

(8) FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunityThe Journal of experimental medicineOctober 5, 2020Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, et al.neutravidin-coated ELISA plates as above. For mIgG1 ICs, unconjugated CD32a variants (Sino Biological; #10374-H08H1-100 and 10374-H08H-100) were coated directly on ELISA plates overnight. Plates were then washed and

(9) FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesProceedings of the National Academy of Sciences of the United States of AmericaJune 9, 2020Borghi S, Bournazos S, Thulin NK, Li C, Gajewski A, Sherwood RW, Zhang S, Harris E, Jagannathan P, Wang LX, et al.ectodomains were injected as analytes. The FcγRs tested were FcγRI (10256-H08H, Sino Biological), FcγRIIaR131(10374-H08H1, Sino Biological), FcγRIIaH131 (10374-H08H1, Sino Biological), FcγRIIb (10259H08H, Sino Biological),

(10) Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodiesmAbsJuly 1, 2019Aoyama M, Hashii N, Tsukimura W, Osumi K, Harazono A, Tada M, Kiyoshi M, Matsuda A, Ishii-Watabe A.glycoengineered anti-CD20 mAbs to recombinant human FcγRs with C-terminal polyhistidine tag (Cat. No. 10256-H08H, 10374-H08H1, 10259-H08H, 10389-H08H1, and 11046-H08H, Sino Biological) was assessed as described previously.47 In

(11) Erwin Uehlinger on the occasion of his 80th birthday, August 8, 1979Pathology, research and practiceDecember 1, 1979Adler CP, Sandritter W.

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Human CD32a / FCGR2A Protein (167 His, His Tag)

Human CD32a / FCGR2A Protein (167 His, His Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

Citations (11)

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Human CD32a / FCGR2A Protein (167 His, His Tag) from Sino Biological, Inc.

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