Mouse CD137 / 4-1BB / TNFRSF9 Protein (soluble form, Fc Tag) 50811-M02H from Sino Biological, Inc.

Product Specs
ItemMouse CD137 / 4-1BB / TNFRSF9 Protein (soluble form, Fc Tag)
CompanySino Biological, Inc.
Price $1,638.00Supplier Page View Company Product Page
Catalog Number50811-M02H
Activity1.Measured by its binding ability in a functional ELISA. Immobilized mouse His-TNFSF9 (Cat:50067-M07H) at 10 µg/ml (100 µl/well) can bind mouse TNFRSF9-Fc, The EC50 of mouse TNFRSF9-Fc is 12.0-29.0 ng/ml. 2.Loaded Recombinant Mouse 4-1BB/CD137 Protein, hFc Tag (Cat. No. 50811-M02H) on proA Biosensor, can bind Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, His Tag (Cat. No. 50067-M07H) with an affinity constant of 0.807 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
Size1 mg
Source/Expression SystemHEK293 Cells
Molecule NameTNFRSF9
SpeciesMouse
Molecular WeightThe secreted recombinant mouse TNFRSF9/Fc is a disulfide-linked homodimer. The reduced monomer comprises 429 amino acids and has a calculated molecular mass of 47 kDa. As a result of glycosylation, the apparent molecular mass of the monomer is approximately 65-75 kDa in SDS-PAGE under reducing conditions
TypeRecombinant protein
Purity> 90 % as determined by SDS-PAGE
Conjugate/TagC-human IgG1-Fc

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Uncovering receptor-ligand interactions using a high-avidity CRISPR activation screening platformScience advancesFebruary 16, 2024Yang L, Sheets TP, Feng Y, Yu G, Bajgain P, Hsu KS, So D, Seaman S, Lee J, Lin L, et al.(SinoBiological, cat. no. MG50067-CM) were incubated with 1 μg of m4-1BB–Fc protein (SinoBiological, cat. no. 50811-M02H) followed by staining with AF647 AffiniPure Donkey Anti-Human IgG (H + L) (Jackson ImmunoResearch, cat.

(2) Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulationFrontiers in immunologyJanuary 1, 2024Hangiu O, Navarro R, Frago S, Rubio-Pérez L, Tapia-Galisteo A, Díez-Alonso L, Gómez-Rosel M, Silva-Pilipich N, Vanrell L, Smerdou C, et al.cat# 344-ER), mouse (m) 4-1BB-hIgG1 Fc chimera (m4-1BB) (SinoBiological Europe GmbH, Germany, cat# 50811-M02H), recombinant mPD-L1 (mPD-L1) (clone B7-H1) or recombinant hPD-L1 (hPD-L1) (clone B7-H1) (Bio-Techne

(3) CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated EncephalopathyNeuromolecular medicineDecember 1, 2023Qiu F, Liu Y, Liu Y, Zhao Z, Zhou L, Chen P, Du Y, Wang Y, Sun H, Zeng C, et al.and RNA extraction. A second set of experiments was conducted using recombinant CD137-Fc protein (#50811-M02H, SinoBiological), to induce CD137L signaling (Yeo et al., 2012), with a human IgG1-Fc fragment (#10702-HNAH,

(4) Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicityiScienceSeptember 16, 2022Hangiu O, Compte M, Dinesen A, Navarro R, Tapia-Galisteo A, Mandrup OA, Erce-Llamazares A, Lázaro-Gorines R, Nehme-Álvarez D, Domínguez-Alonso C, et al.4-1BB/TNFRSF9 Fc chimera,R&D,Cat#838-4B Recombinant mouse 4-1BB/CD137 Fc chimera,SinoBiological,Cat#50811-M02H Biotinylated human FcRn,Immunitrack,Cat#ITF01 Mouse IgG1K,Biolegend,Cat#401402 FcRn wild-type-binding

(5) Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 AgentsCancer immunology researchDecember 1, 2021Assi HH, Wong C, Tipton KA, Mei L, Wong K, Razo J, Chan C, Howng B, Sagert J, Krimm M, et al.(Sino Biological, catalogs #10698-H02H and #50446-M02H), CD137 (Sino Biological, catalogs #10041-H02H and #50811-M02H), OX40 (Sino Biological, catalogs #10481-H02H and #50808-M02H), and GITR (R&D Systems, catalogs #689-GR-100

(6) 4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in MiceFrontiers in immunologyJanuary 1, 2018Lu Y, Li C, Du S, Chen X, Zeng X, Liu F, Chen Y, Chen J.for 7 days. For 4-1BB Fusion Protein Treatment 100 or 50 µg of 4-1BB fusion protein (4-1BBIg; cat: 50811-M02H, Sino Biological Inc., Beijing, China) per mouse or 100 µg isotype IgG (human IgG1; Sino Biological

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Mouse CD137 / 4-1BB / TNFRSF9 Protein (soluble form, Fc Tag)

Mouse CD137 / 4-1BB / TNFRSF9 Protein (soluble form, Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Mouse CD137 / 4-1BB / TNFRSF9 Protein (soluble form, Fc Tag) from Sino Biological, Inc.

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