Human DLL4 Protein (Fc Tag) 10171-H02H from Sino Biological, Inc.

Product Specs
ItemHuman DLL4 Protein (Fc Tag)
CompanySino Biological, Inc.
Price $1,156.00Supplier Page View Company Product Page
Catalog Number10171-H02H
Size500 µg
Conjugate/TagC-human IgG1-Fc
Purity≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human DLL4/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 736 amino acids and predicts a molecular mass of 81 kDa. As a result of glycosylation, the rh DLL4/Fc monomer migrates as approximately 100-110 kDa band in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameDLL4
Source/Expression SystemHEK293 Cells
NCBI Full Gene Namedelta like canonical Notch ligand 4
NCBI Gene AliasesAOS6, delta4, hdelta2
Activity1. Immobilized Recombinant Human NOTCH1 Protein (Fc Tag) (Cat: 10954-H02H) at 2 µg/ml (100 µl/well) can bind Recombinant Human DLL4 Protein (Fc Tag) (Cat: 10171-H02H), the EC50 of Recombinant Human DLL4 Protein (Fc Tag) is 30-120 ng/mL. 2. Measured by the ability of the immobilized protein to enhance BMP2-induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.2-2µg/mL in the presence of 500 ng/mL recombinant human BMP2
FormatLyophilized from sterile PBS, pH 7.4

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Sex-biased human thymic architecture guides T cell development through spatially defined nichesDevelopmental cellJanuary 6, 2025Stankiewicz LN, Salim K, Flaschner EA, Wang YX, Edgar JM, Durland LJ, Lin BZB, Bingham GC, Major MC, Jones RD, et al.

(2) Tracking the gene expression programs and clonal relationships that underlie mast, myeloid, and T lineage specification from stem cellsCell systemsDecember 18, 2024Michaels YS, Major MC, Bonham-Carter B, Zhang J, Heydari T, Edgar JM, Siu MM, Greenstreet L, Vilarrasa-Blasi R, Kim S, et al.

(3) DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cellsJCI insightJanuary 9, 2024Alve S, Gramolelli S, Jukonen J, Juteau S, Pink A, Manninen AA, Hänninen S, Monto E, Lackman MH, Carpén O, et al.room temperature (DLL1-Fc, 10184-DL-050 Biotechne; DLL3-Fc, DL3-H5255 ACRO Biosystems; DLL4-Fc, 158- 10171-H02H-100 Sino Biological; JAG1-Fc, 158-11648-H02H Sino Biological, and JAG2-Fc, 1726-JG-050 R&D Systems).

(4) Adherens junctions organize size-selective proteolytic hotspots critical for Notch signallingNature cell biologyDecember 1, 2022Kwak M, Southard KM, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, et al.

(5) Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicityeLifeOctober 3, 2022Chaurasia SN, Ekhlak M, Kushwaha G, Singh V, Mallick RL, Dash D.protein",DLL-1,Sino Biological,11635-H08H,15 µg/ml "Peptide, recombinant protein",DLL-4,Sino Biological,10171-H02H,7.5–15 µg/ml "Peptide, recombinant protein",Thrombin receptor-activating peptide (TRAP),Sigma-Aldrich,S1820,2–2.5

(6) DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cellsScience advancesAugust 26, 2022Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, et al.using sterile phosphate-buffered saline (PBS) combined with Fc-tagged DLL4 (15 μg/ml; Sino Biological, 10171-H02H) and Fc-tagged VCAM1 (2.5 μg/ml; R&D Systems, 643-VM). Tissue culture–treated 96-well plates (Fisher

(7) Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migrationScientific reportsJanuary 31, 2022Swaminathan B, Youn SW, Naiche LA, Du J, Villa SR, Metz JB, Feng H, Zhang C, Kopan R, Sims PA, et al.FBS. Tethered ligand assay (TLA) The recombinant extracellular domains of the Notch ligands hDLL4-Fc (Cat. 10171-H02H, Sino Biologicals Inc.), hJAG1-Fc (Cat. 11648-H02H, Sino Biologicals Inc.) or IgG-Fc (Cat. 10702-HNAH,

(8) In Vitro Differentiation of T Cell: From Human iPS Cells in Feeder-Free ConditionMethods in molecular biology (Clifton, N.J.)January 1, 2019Yasui Y, Hitoshi Y, Kaneko S.

(9) Inhibition of Delta-induced Notch signaling using fucose analogsNature chemical biologyJanuary 1, 2018Schneider M, Kumar V, Nordstrøm LU, Feng L, Takeuchi H, Hao H, Luca VC, Garcia KC, Stanley P, Wu P, et al.tissue culture plates were coated with Dll1-Fc (R&D Systems, 3970-DL-050), Dll4-Fc (Sino Biological, 10171-H02H-50) or Jag1-Fc (R&D Systems, 599-JG-100) (4 μg/mL per well for each ligand) in PBS for 2 hours at room

(10) Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cellsJournal of leukocyte biologyDecember 1, 2014Huijskens MJ, Walczak M, Koller N, Briedé JJ, Senden-Gijsbers BL, Schnijderberg MC, Bos GM, Germeraad WT.

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Human DLL4 Protein (Fc Tag)

Human DLL4 Protein (Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human DLL4 Protein (Fc Tag) from Sino Biological, Inc.

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