Human NRG1-beta 1 Protein (ECD) 11609-HNCH from Sino Biological, Inc.

Product Specs
ItemHuman NRG1-beta 1 Protein (ECD)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number11609-HNCH
Conjugate/TagN-cleavage
Purity> 90 % as determined by SDS-PAGE
TypeRecombinant protein
Molecular WeightThe recombinant human NRG1 comprises 245 amino acids and has a predicted molecular mass of 26.8 kDa. As a result of glycosylation, it migrates as an approximately 47.7 kDa band in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameNRG1
Source/Expression SystemHEK293 Cells
NCBI Full Gene Nameneuregulin 1
NCBI Gene AliasesARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
Activity1.Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is typically 2-10 ng/mL. 2.Western blot analysis of extracts from serum-starved MCF-7, untreated (-) or treated with neuregulin-1 (Cat # 11609-HNCH) (100 ng/mL, 5 min) using Phospho-HER3/ErbB3 (Tyr1289) rabbit monoclonal Antibody (Cat# 111146-R0004) at 1:2000 dilution (upper), or Anti-HER3/ERBB3 Antibody, Rabbit Polyclonal (Cat# 10201-RP02) at 1:2000 dilution (middle), or Beta-Tubulin Loading Control Antibody, Mouse MAb (Cat# 100109-MM05T) at 1:2000 dilution (lower)(Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Engineering HER2-targeted biparatopic antibodies to promote receptor internalization and restore antitumor efficacyFrontiers in ImmunologyNovember 7, 2025Xinlin Liu, Wanpeng Yu, Yihuan Wang, Dongming Xing, Haiming Huang, Wenjing Zhu, Peng Sunreader. For ligand-dependent assays, tumor cells were stimulated with either 1 nM HRG (SinoBiological, 11609-HNCH) or 5 nM EGF (SinoBiological, GMP-10605-HNAE). Cell viability was calculated as a percentage relative

(2) Biparatopic HER2-targeted nanobody binder synergizes with trastuzumab in resistant tumor cellsFrontiers in ImmunologyOctober 27, 2025Xinlin Liu, Li Guo, Yihuan Wang, Xiangzheng Meng, Yunhan Shao, Xinyi Fan, Cong Wang, Wenjing Zhu, Jingyu Cao, Peng Sunwere stimulated with either 5 nM EGF (SinoBiological, GMP-10605-HNAE) or 1 nM HRG (SinoBiological, 11609-HNCH). Percent viability was calculated relative to untreated controls. Data was analyzed by nonlinear regression

(3) A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cellsFrontiers in ImmunologyOctober 25, 2023Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, et al.ligand-dependent growth inhibition, the 5 nM EGF (SinoBiological, GMP-10605-HNAE) or 1 nM HRG (SinoBiological, 11609-HNCH) were added to stimulate tumor cells. The data and p-values were analyzed by GraphPad Prism 8. 3 Results 3.1

(4) miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cellsNeural regeneration researchApril 15, 2014Ni Y, Zhang K, Liu X, Yang T, Wang B, Fu L, A L, Zhou Y.

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Human NRG1-beta 1 Protein (ECD)

Human NRG1-beta 1 Protein (ECD) from Sino Biological, Inc.

Description

Sino Biological, Inc.

Citations (4)

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Human NRG1-beta 1 Protein (ECD) from Sino Biological, Inc.

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