IL-6 Protein 406-ML-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-6 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $282.00Supplier Page View Company Product Page
Catalog Number406-ML-005
SpeciesMouse
Size5 ug (also 25 ug, 200 ug)
Source/Expression SystemE. coli-derived Recombinant Mouse IL-6 Protein
Molecule NameIL-6
NCBI Full Gene Nameinterleukin 6
NCBI Gene AliasesCDF, HSF, BSF-2, Il-6, IL-6, IFNB2, HGF, BSF2, IFN-beta-2
FormatLyophilized from a 0.2 µm filtered solution in Sodium Acetate and EDTA with Trehalose and with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 5 ug (also 25 ug, 200 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) T H 17 cells converted into exT H 17 cells sustain rheumatoid-like IL-17–independent inflammatory arthritisScience ImmunologyNovember 7, 2025Martina Zoccheddu, Kensuke Suga, Amara Seng, Mattias N. D. Svensson, Paramita Dutta, Sanaz Panahandeh, Hadijat-Kubura Moradeke Makinde, Myungja Ro, Yizhou Wang, Hyobin Kim, et al.or 24 well plates under Th17 cell polarization conditions - T cells media with: 50 ng/mL IL-6 (cat# 406-ML-005 R&D Systems), 5 ng/mL rhTgfb (cat# 240-B-002 R&D Systems), 1 ug/mL LEAF anti-CD28 (clone 37.51 cat#

(2) Respiratory viral infections awaken metastatic breast cancer cells in lungsNatureSeptember 11, 2025Shi B. Chia, Bryan J. Johnson, Junxiao Hu, Felipe Valença-Pereira, Marc Chadeau-Hyam, Fernando Guntoro, Hugh Montgomery, Meher P. Boorgula, Varsha Sreekanth, Andrew Goodspeed, et al.seeding. At day 4 after seeding, cells were treated with either PBS or 10 ng ml−1 IL-6 (R&D Systems, 406-ML-005) for 3 consecutive days. Using a Nikon Eclipse Ti-S microscope, mammospheres were imaged at 4× magnification

(3) Adipocyte-specific deletion of gp130 prevents ketogenic diet–induced hepatic steatosisHepatol CommunAugust 26, 2025Berkay Senkalfa, Melanie Gloor, Ronja Podlaszewski, Revati S. Dewal, Carla Horvath, Vissarion Efthymiou, Adhideb Ghosh, Stephan Wueest, Daniel Konrad, Christian Wolfrum, et al.details are available on request. Recombinant IL-6 administration Recombinant mouse IL-6 (Catalog #406-ML-005, R&D Systems) was reconstituted in sterile PBS containing 0.1% BSA to a final concentration of 10 µg/mL.

(4) Adipocyte-specific deletion of gp130 prevents ketogenic diet–induced hepatic steatosisHepatol CommunAugust 26, 2025Berkay Senkalfa, Melanie Gloor, Ronja Podlaszewski, Revati S. Dewal, Carla Horvath, Vissarion Efthymiou, Adhideb Ghosh, Stephan Wueest, Daniel Konrad, Christian Wolfrum, et al.details are available on request. Recombinant IL-6 administration Recombinant mouse IL-6 (Catalog #406-ML-005, R&D Systems) was reconstituted in sterile PBS containing 0.1% BSA to a final concentration of 10 µg/mL.

(5) Integration of phospho-signaling and transcriptomics in single cells reveals distinct Th17 cell fatesCell reportsAugust 26, 2025Fortmann SD, Chadha AS, Frey BF, Elahi A, Hanumanthu VS, Liu S, Goldsborough A, Ferrell PB Jr, Grant MB, Weaver CT, et al.

(6) Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potentialNature communicationsAugust 7, 2025Wu R, Salehi F, Redecke V, Ma Z, Marchetti M, Finkelstein D, Xu P, Cheng Y, Queisser KA, Petrey AC, et al.

(7) PROCR diminishes the efficacy of radiation by impairing T-cell-mediated antitumour immunityNature communicationsAugust 4, 2025Chen W, Zhang C, Li Z, Xu Z, Ding C, Wu J, Wei H, Deng Z, He T, Long L, et al.

(8) Taurine from tumour niche drives glycolysis to promote leukaemogenesisNatureAugust 1, 2025Sharma S, Rodems BJ, Baker CD, Kaszuba CM, Franco EI, Smith BR, Ito T, Swovick K, Welle K, Zhang Y, et al.

(9) Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammationNatureJuly 1, 2025White Z, Cabrera I, Mei L, Clevenger M, Ochoa-Raya A, Kapustka I, Dominguez JR, Zhou J, Koster KP, Anwar S, et al.

(10) Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4(+) T cells through STAT1-related epigenetic mechanismseLifeMay 14, 2025Zhang J, Tang H, Wu H, Pang X, Jin R, Zhang Y.

(11) IL‐6 Signalling to Responding T Cells Is Key to Calcitonin Gene‐Related Peptide‐Exposed Endothelial Cell Enhancement of Th17 Immunity During Langerhans Cell Antigen PresentationImmunologyApril 1, 2025Wanhong Ding, Cameron Moattari, Lori L. Stohl, John A. Wagner, Xi K. Zhou, Richard D. GransteinPOV-3636-PI). Purified mouse recombinant IL-6 was purchased from R&D Systems (Minneapolis, MN. Cat# 406-ML-005). Purified anti-mouse CD126 (IL6Rα, clone D7715A7. Cat# 16-1261-85) and isotype control were purchased

(12) Modulation of gut propionate and intestinal mucosal protection by Bifidobacterium longum: Mitigating methotrexate side effects without compromising the efficacy of psoriasis therapyInternational immunopharmacologyMarch 6, 2025Mao M, Yuan Y, Li R, Kuang Y, Lu Y, Zhu W, Chen W.

(13) IL-27 elicits a cytotoxic CD8(+) T cell program to enforce tumour controlNatureMarch 1, 2025Bréart B, Williams K, Krimm S, Wong T, Kayser BD, Wang L, Cheng E, Cruz Tleugabulova M, Bouziat R, Lu T, et al.

(14) Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's disease via the prosaposin-GPR37-IL-6 axisCell reportsFebruary 25, 2025Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu JB, Yang J, Tang BJ, Li S, Qiu M, et al.

(15) Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responsesCell researchFebruary 1, 2025Zhao Q, Wang Q, Yao Q, Yang Z, Li W, Cheng X, Wen Y, Chen R, Xu J, Wang X, et al.

(16) The CEMIP Hyaluronidase is Elevated in Oligodendrocyte Progenitor Cells and Inhibits Oligodendrocyte MaturationASN neuroJanuary 1, 2025Peters A, Yasuhara K, Su W, Matsumoto S, Pham P, Banine F, Harris E, Back SA, Sherman LS.treated with either vehicle (PBS), or TNFα (R&D Systems, 10291-TA-020; 10 ng/mL) or IL6 (R&D Systems, 406-ML-005; 100 ng/ml). Growth factor and cytokine activity and concentration optimization was confirmed by Western blots

(17) InTraSeq: A Multimodal Assay that Uncovers New Single-Cell Biology and Regulatory MechanismsResearch squareDecember 9, 2024Beausoleil S, Ariss M, Huang L, Ding X, Sheth S, Levy T, Fisher J, Loebelenz J, Arlotta K, Dixon K, et al.

(18) Programming tissue-sensing T cells that deliver therapies to the brainScienceDecember 6, 2024Milos S. Simic, Payal B. Watchmaker, Sasha Gupta, Yuan Wang, Sharon A. Sagan, Jason Duecker, Chanelle Shepherd, David Diebold, Psalm Pineo-Cavanaugh, Jeffrey Haegelin, et al.(R&D Systems, catalog no. 1887-ML-010) and 10 ng/μl recombinant mouse IL-6 (R&D Systems, catalog no. 406-ML-005). After three days of culture, cells were harvested, washed, and 20 to 25 × 106 cells were injected

(19) Neutrophil extracellular traps promote tumor chemoresistance to anthracyclinesbioRxiv : the preprint server for biologyNovember 11, 2024Lin C, Herlihy SE, Li M, Deng H, Kim R, Bernabei L, Rosenwasser M, Gabrilovich DI, Vogl DT, Nefedova Y.

(20) Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor GrowthCancer discoveryOctober 4, 2024Donahue KL, Watkoske HR, Kadiyala P, Du W, Brown K, Scales MK, Elhossiny AM, Espinoza CE, Lasse Opsahl EL, Griffith BD, et al.

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Recombinant Mouse IL-6 Protein

IL-6 Protein

IL-6 Protein

IL-6 Protein

IL-6 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Reviews

IL-6 Protein from R&D Systems, a Bio-Techne Brand

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