Recombinant Human CNTF Protein 257-NT-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human CNTF Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $257.00Supplier Page View Company Product Page
Catalog Number257-NT-010
SpeciesHuman
Molecule NameCNTF
Size10 ug (also 50 ug)
NCBI Full Gene Nameciliary neurotrophic factor
NCBI Gene AliasesHCNTF
FormatLyophilized from a 0.2 µm filtered solution in Tris, NaCl, TCEP, EDTA, CHAPS and Trehalose with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 23-26 kDa, reducing conditions
Theoretical: 22.8 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human CNTF Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A Human Model of Oligodendrocyte Development Shows MCL-1 Influences Oligodendrocyte MorphogenesisGliaDecember 19, 2025Melanie Gil, Marina R. Hanna, Vivian Gamaminus vitamin A supplement, 0.2 μg/mL Ascorbic Acid (Sigma‐Aldrich, A4403), 10 ng/mL CNTF (R&D Systems, 257‐NT‐010), 10 ng/mL BDNF (Peprotech, 11166‐BD‐010), and 10 ng/mL GDNF (R&D Systems, 11166‐BD‐010). The following

(2) Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned MediaACS Chem NeurosciAugust 6, 2025Vera M. Masegosa, Elsa Fritz, Daniela Corvalan, Fabiola Rojas, Polett Garcés, Xavier Navarro, Petra Bloms-Funke, Brigitte van Zundert, Mireia Herrando-GrabulosaB27, 10 ng/mL Heregulin, 5 ng/mL BMP2 (BioVision, Cat. #4577-50) and 2 ng/mL CNTF (R&D Systems, Cat. #257-NT-010)]. Next, immunofluorescence assays were performed as previously described , to confirm the development

(3) Long-Term Durability of Ciliary Neurotrophic Factor-Releasing Revakinagene Taroretcel-lwey in Individuals With Retinal Degenerative DisordersInvestigative ophthalmology & visual scienceAugust 1, 2025Kauper K, Nystuen A, Orecchio L, Gonzalez-Lopez E, Lee A, Duncan JL, Stewart JM, Aaberg T Jr.

(4) Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALSNat CommunMay 19, 2025Christoph Schweingruber, Jik Nijssen, Jonas Mechtersheimer, Stefan Reber, Mélanie Lebœuf, Niamh L. O'Brien, Irene Mei, Erin Hedges, Michaela Keuper, Julio Aguila Benitez, et al.248-BD-025], GDNF [R&D Systems, 212-GD-010], NT-3 [R&D Systems, 267-N3-025], and CNTF [R&D Systems, 257-NT-010]), and three days of medium d11–13 (3 µM CHIR99021, 25 ng/mL SHH-C25II, 250 nM Purmorphamine, 1 µM retinoic

(5) The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neuronsPloS oneJanuary 1, 2025Policarpo R, Wolfs L, Martínez-Montero S, Vandermeulen L, Royaux I, Van Peer G, Mestdagh P, De Strooper B, Sierksma A, d'Ydewalle C.

(6) Localized molecular chaperone synthesis maintains neuronal dendrite proteostasisNature communicationsDecember 30, 2024Alecki C, Rizwan J, Le P, Jacob-Tomas S, Comaduran MF, Verbrugghe M, Xu JMS, Minotti S, Lynch J, Biswas J, et al.

(7) MCL-1 regulates cellular transitions during oligodendrocyte developmentbioRxivDecember 23, 2024Melanie Gil, Marina R Hanna, Vivian Gamaminus vitamin A supplement, 0.2 ug/mL Ascorbic Acid (Sigma-Aldrich, A4403), 10 ng/mL CNTF (R&D Systems, 257-NT-010), 10 ng/mL BDNF (Peprotech, 11166-BD-010), and 10 ng/mL GDNF (R&D Systems, 11166-BD-010). The following

(8) Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformationsCell death & diseaseMay 30, 2024Werren EA, Peirent ER, Jantti H, Guxholli A, Srivastava KR, Orenstein N, Narayanan V, Wiszniewski W, Dawidziuk M, Gawlinski P, et al.

(9) Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMRThe Journal of biological chemistryMay 1, 2024Rafii P, Cruz PR, Ettich J, Seibel C, Padrini G, Wittich C, Lang A, Petzsch P, Köhrer K, Moll JM, et al.

(10) Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derived C9orf72-associated ALS/FTD motor neuronsbioRxiv : the preprint server for biologyMarch 26, 2024Martin EJ, Santacruz C, Mitevska A, Jones IE, Krishnan G, Gao FB, Finan JD, Kiskinis E.

(11) Monitoring phosphorylation and acetylation of CRISPR-mediated HiBiT-tagged endogenous proteinsScientific reportsJanuary 25, 2024Alves J, Schwinn M, Machleidt T, Goueli SA, Cali JJ, Zegzouti H.

(12) Human spinal interneurons repair the injured spinal cord through synaptic integrationbioRxiv : the preprint server for biologyJanuary 12, 2024Zholudeva LV, Fortino T, Agrawal A, Vila OF, Williams M, McDevitt T, Lane MA, Srivastava D.

(13) Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathyFrontiers in cellular neuroscienceJanuary 1, 2024Sun Y, Chen D, Dai T, Yu Z, Xie H, Wang X, Zhang W.

(14) H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programsbioRxiv : the preprint server for biologyNovember 28, 2023Krug B, Hu B, Chen H, Ptack A, Chen X, Gretarsson KH, Deshmukh S, Kabir N, Andrade AF, Jabbour E, et al.

(15) CRISPR/Cas9 Directed Reprogramming of iPSC for Accelerated Motor Neuron Differentiation Leads to Dysregulation of Neuronal Fate Patterning and FunctionInternational journal of molecular sciencesNovember 10, 2023Davis-Anderson K, Micheva-Viteva S, Solomon E, Hovde B, Cirigliano E, Harris J, Twary S, Iyer R.

(16) CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiologyScience advancesNovember 10, 2023Ortega JA, Sasselli IR, Boccitto M, Fleming AC, Fortuna TR, Li Y, Sato K, Clemons TD, Mckenna ED, Nguyen TP, et al.

(17) Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasisCell reportsOctober 31, 2023Tsioras K, Smith KC, Edassery SL, Garjani M, Li Y, Williams C, McKenna ED, Guo W, Wilen AP, Hark TJ, et al.

(18) A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cellsStem cell reportsAugust 8, 2023Jovanovic VM, Weber C, Slamecka J, Ryu S, Chu PH, Sen C, Inman J, De Sousa JF, Barnaeva E, Hirst M, et al.

(19) Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neuronsCell reportsApril 25, 2023Sharma SD, Reddy BK, Pal R, Ritakari TE, Cooper JD, Selvaraj BT, Kind PC, Chandran S, Wyllie DJA, Chattarji S.

(20) High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assemblyeLifeApril 21, 2023Berryer MH, Rizki G, Nathanson A, Klein JA, Trendafilova D, Susco SG, Lam D, Messana A, Holton KM, Karhohs KW, et al.

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Recombinant Human CNTF Protein

CNTF Protein

CNTF Protein

CNTF Protein

Recombinant Human CNTF Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human CNTF Protein from R&D Systems, a Bio-Techne Brand

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