Recombinant Human NRG1/HRG1 Protein, CF 5898-NR-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human NRG1/HRG1 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $408.00Supplier Page View Company Product Page
Catalog Number5898-NR-050
FormatLyophilized from a 0.2 µm filtered solution in PBS
SpeciesHuman
Molecule NameNeuregulin-1/NRG1
Size50 ug
NCBI Full Gene Nameneuregulin 1
NCBI Gene AliasesGGF2, SMDF, ARIA, NRG1-IT2, HRGA, MST131, HGL, GGF, MSTP131, HRG, NDF, HRG1
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 40-43 kDa, reducing conditions
Theoretical: 24.8 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human NRG1/HRG1 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Glutamine metabolism prognostic index predicts tumour microenvironment characteristics and therapeutic efficacy in ovarian cancerJournal of cellular and molecular medicineApril 1, 2024Gao L, Wei Z, Ying F, Huang L, Zhang J, Sun S, Wang Z, Cai J, Zhang Y.

(2) Prostaglandin D2 synthase controls Schwann cells metabolismbioRxiv : the preprint server for biologyMarch 4, 2024Trimarco A, Audano M, Marca R, Cariello M, Falco M, Pedretti S, Imperato G, Cestaro A, Podini P, Dina G, et al.

(3) Nuclear VANGL2 Inhibits Lactogenic DifferentiationCellsJanuary 25, 2024Rubio S, Molinuevo R, Sanz-Gomez N, Zomorrodinia T, Cockrum CS, Luong E, Rivas L, Cadle K, Menendez J, Hinck L.B-27 (Thermo-Fisher, Waltham, MA, USA; 12587010), 100 ng/mL Nrg1 (R&D Systems Minneapolis, MN, USA; 5898-NR-050), 42.5 ng/mL R-spondin (Thermo-Fisher, Waltham, MA, USA; 120-38), 1 nM Rho-inhibitor (Y-27632; Cell Signaling Technologies

(4) Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growthDisease models & mechanismsApril 1, 2023Lemmetyinen TT, Viitala EW, Wartiovaara L, Kaprio T, Hagström J, Haglund C, Katajisto P, Wang TC, Domènech-Moreno E, Ollila S.

(5) EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroidsJCI insightMarch 22, 2023Childs CJ, Holloway EM, Sweet CW, Tsai YH, Wu A, Vallie A, Eiken MK, Capeling MM, Zwick RK, Palikuqi B, et al.Systems, catalog 236-EG, 100 ng/mL, 10 ng/mL, or 1 ng/mL) or recombinant human EREG (R&D Systems, catalog 5898-NR-050, 100 ng/mL, 10 ng/mL, or 1 ng/mL) was added. Experimental design of enteroid cultures. The enteroid

(6) Neuregulin 1 (NRG1) modulates oocyte nuclear maturation during IVM and improves post-IVF embryo developmentTheriogenologyJanuary 1, 2023Dellaqua TT, Vígaro RA, Janini LCZ, Dal Canto M, Renzini MM, Lodde V, Luciano AM, Buratini J.

(7) Mapping Development of the Human Intestinal Niche at Single-Cell ResolutionCell stem cellMarch 4, 2021Holloway EM, Czerwinski M, Tsai YH, Wu JH, Wu A, Childs CJ, Walton KD, Sweet CW, Yu Q, Glass I, et al.

(8) Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targetingNature communicationsMarch 2, 2021Du Z, Brown BP, Kim S, Ferguson D, Pavlick DC, Jayakumaran G, Benayed R, Gallant JN, Zhang YK, Yan Y, et al.

(9) Cordycepin inhibits the proliferation of malignant peripheral nerve sheath tumor cells through the p53/Sp1/tubulin pathwayAmerican journal of cancer researchJanuary 1, 2021Lee MJ, Lee JC, Hsieh JH, Lin MY, Shih IA, You HL, Wang K.

(10) Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunctionCommun Med (Lond)January 1, 2021Jeong M, Ocwieja KE, Han D, Wackym PA, Zhang Y, Brown A, Moncada C, Vambutas A, Kanne T, Crain R, et al.Accutase (StemCell Technologies, Cat# 07920) and cultured in Neuregulin-1 (NRG-1; R&D Systems, Cat# 5898-NR-050) containing NDM (=SCPM). The cells were split and replated every 3~4 days by using Accutase. The hiPSC-derived

(11) Targeted PMP22 TATA-box editing by CRISPR/Cas9 reduces demyelinating neuropathy of Charcot-Marie-Tooth disease type 1A in miceNucleic acids researchJanuary 10, 2020Lee JS, Lee JY, Song DW, Bae HS, Doo HM, Yu HS, Lee KJ, Kim HK, Hwang H, Kwak G, et al.

(12) Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative responseThe Journal of biological chemistryJanuary 25, 2019Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu SS.

(13) SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent TumorsCell reportsJanuary 2, 2019Ahmed TA, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson SA, Poulikakos PI.,R&D systems,Cat#206-IL-010 Recombinant Human EGF protein,Invitrogen,Cat# PHG0311 Recombinant Human NRG1 protein,R&D systems,Cat# 5898-NR-050 Human Basic Fibroblast Growth Factor (hFGF basic/FGF2),Cell Signaling,Cat#8910 Recombinant protein G agarose

(14) Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancersBreast cancer research : BCRAugust 9, 2018Osada T, Hartman ZC, Wei J, Lei G, Hobeika AC, Gwin WR, Diniz MA, Spector N, Clay TM, Chen W, et al.

(15) Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculationNatureMay 1, 2018Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, et al.

(16) Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IVmAbsJuly 1, 2017Schmitt LC, Rau A, Seifert O, Honer J, Hutt M, Schmid S, Zantow J, Hust M, Dübel S, Olayioye MA, et al.

(17) Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillationTranslational psychiatryMarch 7, 2017Kawata M, Morikawa S, Shiosaka S, Tamura H.

(18) Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kα-selective Inhibitors in Breast CancerTheranosticsJanuary 1, 2017Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J, Meng LH.

(19) The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitisThe American journal of pathologyOctober 1, 2014McElroy SJ, Castle SL, Bernard JK, Almohazey D, Hunter CJ, Bell BA, Al Alam D, Wang L, Ford HR, Frey MR.

(20) Alveolar progenitor and stem cells in lung development, renewal and cancerNatureMarch 13, 2014Desai TJ, Brownfield DG, Krasnow MA.TGFα (4 uM, R&D Systems 239-A-100), HB-EGF (4 uM, R&D Systems 259-HE-050), NRG1 (4 uM, R&D Systems 5898-NR-050) or a function blocking anti-EGFR antibody (rat, Abcam AB231, clone ICR10; 2.5 ug/mL) was added and

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Recombinant Human NRG1/HRG1 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human NRG1/HRG1 Protein, CF from R&D Systems, a Bio-Techne Brand

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