IL-12 Protein 419-ML-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-12 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $344.00Supplier Page View Company Product Page
Catalog Number419-ML-010
SpeciesMouse
Size10 ug (also 50 ug, 500 ug)
Molecule NameIL-12
NCBI Full Gene Nameinterleukin 12b, interleukin 12A, interleukin 12a
NCBI Gene AliasesLl12a, CLMF, Il-12p40, Il-12b, NFSK, IL-12p35, Il-12a, NKSF1, Il12p40, P35, IL-12A, p35, p40
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Mouse IL-12 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 10 ug (also 50 ug, 500 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Organ injury in systemic autoimmunity is mediated by stem-like CD8+ T cells arising from tissue-draining lymph nodesImmunityApril 20, 2026Jafar Al Souz, Yulong Wei, Can Cui, Rihao Qu, Jin-Young Choi, Fang Wang, Steven J. Moioffer, Julia Barrett, Irene Chernova, Manvitha Nadella, et al.with carrier,R&D Systems,Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier,R&D Systems,Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier,R&D Systems,Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein

(2) Metabolically reprogrammed eosinophils impair T cell immunity and cause chronic skin infectionEMBO Molecular MedicineMarch 11, 2026David Barinberg, Heidi Sebald, Tobias Gold, Baplu Rai, Daniel Radtke, Dominik Lerm, David Voehringer, Jonathan Jantsch, Stefan Wirtz, Alina Ulezko Antonova, et al.,Thermo Fisher Scientific,#N13195 DAPI Fluoromount G,Southern Biotec,#0100-20 Recombinant mouse IL-12,R&D System,#419-ML-010 Recombinant mouse IL-2,R&D System,#402-ML-020 Recombinant mouse IL-4,Thermo Fisher Scientific Peprotech,#214-14 Phorbol-12-myristate-13-acetate

(3) Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4(+) T cells through STAT1-related epigenetic mechanismseLifeMay 14, 2025Zhang J, Tang H, Wu H, Pang X, Jin R, Zhang Y.

(4) Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast CancerCancer immunology researchApril 2, 2025Schwarz E, Savardekar H, Zelinskas S, Mouse A, Lapurga G, Lyberger J, Rivaldi A, Ringwalt EM, Miller KE, Yu L, et al.

(5) IL-27 elicits a cytotoxic CD8(+) T cell program to enforce tumour controlNatureMarch 1, 2025Bréart B, Williams K, Krimm S, Wong T, Kayser BD, Wang L, Cheng E, Cruz Tleugabulova M, Bouziat R, Lu T, et al.

(6) KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infectionScienceFebruary 14, 2025Eric Fagerberg, John Attanasio, Christine Dien, Jaiveer Singh, Emily A. Kessler, Leena Abdullah, Jian Shen, Brian G. Hunt, Kelli A. Connolly, Edward De Brouwer, et al.with 10 ng/mL, 1 ng/mL, 0.1 ng/mL, or 0.01 ng/mL of IL-2 (PeproTech, Z 200-02), IL-12 (R&D Systems, 419-ML-010), IL-15 (PeproTech, 210-15), IFNβ (R&D Systems, 8234-MB-010), IL-12 (R&D Systems, 419-ML), or TGFβ (R&D Systems

(7) Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasionScience advancesJanuary 24, 2025Zotta A, Toller-Kawahisa J, Palsson-McDermott EM, O'Carroll SM, Henry ÓC, Day EA, McGettrick AF, Ward RW, Ryan DG, Watson MA, et al.

(8) Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammationJournal of neuroinflammationNovember 5, 2024Angiari S, Carlucci T, Budui SL, Bach SD, Dusi S, Walter J, Ellmeier E, Schnabl A, Stracke A, Bordag N, et al.

(9) Neuropeptide signalling orchestrates T cell differentiationNatureNovember 1, 2024Hou Y, Sun L, LaFleur MW, Huang L, Lambden C, Thakore PI, Geiger-Schuller K, Kimura K, Yan L, Zang Y, et al.

(10) Development of a targeted IL-12 immunotherapy platform for B-cell lymphomasInternational immunopharmacologySeptember 30, 2024Lee D, Kim D, Kim D, Kim N, Nam YW, Lee BC, Song J, Chang J.

(11) Impact of AIM2 on HNSCC DevelopmentbioRxiv : the preprint server for biologySeptember 28, 2024Reinartz DM, Escamilla-River V, Tribble SL, Caulin C, Wilson JE.

(12) IL-2 delivery to CD8(+) T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamicsNature communicationsSeptember 11, 2024Maurice D, Costello P, Diring J, Gualdrini F, Frederico B, Treisman R.

(13) An intestinal T(H)17 cell-derived subset can initiate cancerNature immunologySeptember 1, 2024Fesneau O, Thevin V, Pinet V, Goldsmith C, Vieille B, M'Homa Soudja S, Lattanzio R, Hahne M, Dardalhon V, Hernandez-Vargas H, et al.eBioscience) in RPMI medium supplemented with 10% FBS. Culture medium was completed with 10 ng ml–1 IL-12 (419-ML-010, R&D Systems) and 20 μg ml–1 anti-IL-4 (BE0045, BioXcell). Cells were cultured at 5% CO2 and 37 °C for

(14) BACH2 regulates diversification of regulatory and proinflammatory chromatin states in T(H)17 cellsNature immunologyAugust 1, 2024Thakore PI, Schnell A, Huang L, Zhao M, Hou Y, Christian E, Zaghouani S, Wang C, Singh V, Singaraju A, et al.

(15) The PP2A regulatory subunit PPP2R2A controls NAD(+) biosynthesis to regulate T cell subset differentiation in systemic autoimmunityCell reportsJuly 23, 2024Pan W, Tsokos MG, Scherlinger M, Li W, Tsokos GC.riboside chloride,ChromaDex,TruNiagen Nicotinamide riboside,Combi-Blocks,HB-5832 IL-12,R&D Systems,419-ML-010 TGF-β1,R&D Systems,7666-MB-005 IL-2,R&D Systems,402-ML-020 IL-6,R&D Systems,406-ML-005 ,, Critical

(16) Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsisiScienceJuly 19, 2024Assis PA, Allen RM, Schaller MA, Kunkel SL, Bermick JR.G5388 Dynabeads™ mouse T-cell activator CD3/CD28,ThemoFisher,Cat# 11452D Recombinant mouse IL-12,R&D Systems,Cat# 419-ML-010 Recombinant mouse IL-6,R&D Systems,Cat# 406-ML-005 Recombinant mouse IL-23,Prepotech,Cat# 200-23 Recombinant

(17) An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammationFrontiers in ImmunologyJune 25, 2024Liqiong Jiang, Lars P. Lunding, William S. Webber, Karsten Beckmann, Tania Azam, Jesper Falkesgaard Højen, Jesus Amo-Aparicio, Alberto Dinarello, Tom T. Nguyen, Ulrich Pessara, et al.MN, # 23–016-648). Mouse IL-18 and IL-12 were from Bio-Techne (Minneapolis, MN, # 9139-IL-010 and # 419-ML-010). Clinical grade recombinant human IL-18BP was a gift provided by Serono pharmaceutical research institute

(18) Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor EffectsCancer immunology researchJune 4, 2024Menachem A, Alteber Z, Cojocaru G, Fridman Kfir T, Blat D, Leiderman O, Galperin M, Sever L, Cohen N, Cohen K, et al.

(19) A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specificationImmunityMay 14, 2024Chunhong Liu, Hiroyuki Nagashima, Nilisha Fernando, Victor Bass, Jaanam Gopalakrishnan, Sadie Signorella, Will Montgomery, Ai Ing Lim, Oliver Harrison, Lauren Reich, et al.splenocytes were incubated for 6 hours with or without interleukin-12 (IL-12, 10 ng/mL, R&D Systems, #419-ML-010), interleukin-18 (IL-18, 100 ng/mL, R&D Systems, #9139-IL-010), phorbol 12-myristate 13-acetate (PMA,

(20) Fatty acid oxidation fuels natural killer cell responses against infection and cancerProceedings of the National Academy of Sciences of the United States of AmericaMarch 12, 2024Sheppard S, Srpan K, Lin W, Lee M, Delconte RB, Owyong M, Carmeliet P, Davis DM, Xavier JB, Hsu KC, et al.

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Recombinant Mouse IL-12 Protein

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IL-12 Protein

IL-12 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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IL-12 Protein from R&D Systems, a Bio-Techne Brand

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