Recombinant Human IL-22 Protein, CF 782-IL-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-22 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $408.00Supplier Page View Company Product Page
Catalog Number782-IL-010/CF
Size10 ug (also 50 ug, 200 ug, 1 mg)
FormatLyophilized from a 0.2 µm filtered solution in PBS
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
SpeciesHuman
Source/Expression SystemE. coli-derived Recombinant Human IL-22 Protein, CF
Molecule NameIL-22
Molecular Weight16.5 kDa
NCBI Full Gene Nameinterleukin 22
NCBI Gene Aliaseszcyto18, IL-TIF, IL-22, IL-21, IL-D110, TIFa, ILTIF, TIFIL-23
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Type I interferons increase expression of endogenous retrovirus K102 and envelope protein in myeloid cells from patients with autoimmune diseaseMobile DNASeptember 30, 2025Ethan Le, Fatemeh Moadab, Xiaoxing Wang, Rayan Najjar, Alison Bays, Kathryn M. Hastie, Jeremy Shek, Erica Ollmann Saphire, Tomas Mustelin79-55I-L010CF), 100 ng/ml IL-18 (R&D systems cat# 91-24I-L010CF), 100 ng/ml IL-22 (R&D systems cat# 782IL010CF), or 50 ng/ml IL-33 (R&D systems cat# 3625IL010CF). An unstimulated control was also included at 0h.

(2) Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-γ in ex vivo skin culturesFront Cell Dev BiolJuly 17, 2025Hannes Kühtreiber, Corinne Drexler, Melanie Salek, Lisa Auer, Johannes Griss, Michael Mildner, Peter FuchsIL-17A (R&D Systems®, cat#: 7955-IL/CF; n = 6), 10 ng/mL recombinant human IL-22 (R&D Systems®, cat#: 782-IL-010/CF; n = 4), 10 ng/mL recombinant human IL-1β (BioLegend®, cat#: 579402; n = 6), 10 ng/mL recombinant human IFN- γ

(3) Interferons and Cytokines Induce Transcriptional Activation of the Long‐Interspersed Element‐1 in Myeloid Cells from Autoimmune PatientsEuropean Journal of ImmunologyMarch 11, 2025Ethan Le, Fatemeh Moadab, Xiaoxing Wang, Rayan Najjar, Sadie J. Van den Bogaerde, Alison Bays, John LaCava, Tomas Mustelincat#79–55I-L010CF), 100 ng/ml IL-18 (R&D systems cat# 91–24I-L010CF), 100 ng/ml IL-22 (R&D systems cat# 782IL010CF), or 50 ng/ml IL-33 (R&D systems cat# 3625IL010CF). In each experiment, an unstimulated (negative control)

(4) Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer CellsCancersOctober 12, 2022Maresca C, Di Maggio G, Stolfi C, Laudisi F, Colella M, Pacifico T, Di Grazia A, Di Fusco D, Congiu D, Guida AM, et al.

(5) Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid ExtractVeterinary sciencesJune 27, 2022Segarra S, Naiken T, Garnier J, Hamon V, Coussay N, Bernard FX.

(6) Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cellsThe Journal of biological chemistryFebruary 1, 2022Carroll DJ, Burns MWN, Mottram L, Propheter DC, Boucher A, Lessen GM, Kumar A, Malaker SA, Xing C, Hooper LV, et al.

(7) PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in PsoriasisCellsOctober 2, 2021Mercurio L, Morelli M, Scarponi C, Scaglione GL, Pallotta S, Albanesi C, Madonna S.

(8) miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory ResponseCellsSeptember 26, 2021Abdallah F, Henriet E, Suet A, Arar A, Clemençon R, Malinge JM, Lecellier G, Baril P, Pichon C.

(9) Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activationArthritis research & therapyMay 21, 2021Hawerkamp HC, Domdey A, Radau L, Sewerin P, Oláh P, Homey B, Meller S.

(10) Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathwayArthritis research & therapySeptember 23, 2020Min HK, Won JY, Kim BM, Lee KA, Lee SJ, Lee SH, Kim HR, Kim KW.

(11) Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infectionMucosal immunologyJanuary 1, 2020Hebert KD, Mclaughlin N, Galeas-Pena M, Zhang Z, Eddens T, Govero A, Pilewski JM, Kolls JK, Pociask DA.

(12) Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat DietCellsDecember 6, 2019Kim EY, Noh HM, Choi B, Park JE, Kim JE, Jang Y, Lee HK, Chang EJ.

(13) TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytesJournal of dermatological scienceOctober 1, 2019Sugihara S, Sugimoto S, Tachibana K, Kobashi M, Nomura H, Miyake T, Hirai Y, Yamasaki O, Morizane S.

(14) Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin ModelsCellsSeptember 15, 2019Chamcheu JC, Esnault S, Adhami VM, Noll AL, Banang-Mbeumi S, Roy T, Singh SS, Huang S, Kousoulas KG, Mukhtar H.

(15) IL-22 Binding Protein Promotes the Disease Process in Multiple SclerosisJournal of immunology (Baltimore, Md. : 1950)August 15, 2019Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, Lindén M, Abdelmagid N, Tandre K, Hollins C, Irving L, Glover C, et al.

(16) IL-36γ regulates mediators of tissue homeostasis in epithelial cellsCytokineJuly 1, 2019Heath JE, Scholz GM, Veith PD, Reynolds EC.

(17) Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytesCell death & diseaseMarch 20, 2019Sun S, Zhang X, Xu M, Zhang F, Tian F, Cui J, Xia Y, Liang C, Zhou S, Wei H, et al.

(18) R. nukuhivensis acts by reinforcing skin barrier function, boosting skin immunity and by inhibiting IL-22 induced keratinocyte hyperproliferationScientific reportsMarch 11, 2019Abdallah F, Lecellier G, Raharivelomanana P, Pichon C.

(19) The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic TissuesMediators of inflammationJanuary 1, 2019Xu X, Fukui H, Ran Y, Wang X, Inoue Y, Ebisudani N, Nishimura H, Tomita T, Oshima T, Watari J, et al.

(20) IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatmentCell death & diseaseOctober 30, 2018Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, et al.

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Recombinant Human IL-22 Protein, CF

IL-22 Protein

IL-22 Protein

IL-22 Protein

IL-22 Protein

Recombinant Human IL-22 Protein, CF from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

Citations (69)

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Recombinant Human IL-22 Protein, CF from R&D Systems, a Bio-Techne Brand

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