IL-1 alpha/IL-1F1 Protein 400-ML-005/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-1 alpha/IL-1F1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $303.00Supplier Page View Company Product Page
Catalog Number400-ML-005/CF
SpeciesMouse
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size5 ug (also 25 ug)
Source/Expression SystemE. coli-derived Recombinant Mouse IL-1 alpha/IL-1F1 Protein, CF
Molecule NameIL-1 alpha/IL-1F1
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight18 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameinterleukin 1 alpha
NCBI Gene AliasesIL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1

Specifications/Features

Available conjugates: Sizes Available: 5 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progressionCancer DiscovMay 1, 2026Jérémy Nigri, Wenjun Lan, Melanie L. Fung, Charlotte Kayser, Astrid Deschênes, Juliene Hinds, Sanjeev Kaushalya, Sara A. Pawlak, Jennifer S. Thalappillil, Sandeep Nadella, et al.were treated with 20ng/mL mouse TGF-β1 (763104, Biolegend, PubChem CID:56842206), 1ng/mL mouse IL-1α (400-ML-005/CF, R&D Systems), 10μM Noradrenaline bitartrate (5169, Tocris, PubChem CID:53399078), 10μM Doxazosin mesylate

(2) Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer ProgressionCancer DiscoveryMay 1, 2026Jérémy Nigri, Wenjun Lan, Melanie L. Fung, Charlotte Kayser, Astrid Deschênes, Juliene Hinds, Sanjeev Kaushalya, Sara A. Pawlak, Jennifer S. Thalappillil, Sandeep Nadella, et al.were treated with 20ng/mL mouse TGF-β1 (763104, Biolegend, PubChem CID:56842206), 1ng/mL mouse IL-1α (400-ML-005/CF, R&D Systems), 10μM Noradrenaline bitartrate (5169, Tocris, PubChem CID:53399078), 10μM Doxazosin mesylate

(3) IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sicknessCellJanuary 8, 2026Liu Yang, Matias L. Andina, Mario Witkowski, Hunter King, Ian Wickersham, Jun R. Huh, Gloria B. Choi,R&D Systems,1204-ML-025/CF IL-22,R&D Systems,582-ML-010/CF IFN-α A,R&D Systems,12100–1 IL-1α,R&D Systems,400-ML-005/CF IL-1β-CF,R&D Systems,401-ML-010/CF TNFα-CF,R&D Systems,410-MT-010/CF lymphotoxin,R&D Systems,9968-LY-025/CF CXCL1,R&D Systems

(4) Damage-induced pyroptosis drives endogenous thymic regeneration by activating the purinergic receptor P2Y2Cell Death & DiseaseJanuary 3, 2026Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Erin Kirsche, Makya Warren, Paul deRoos, Antonella Cardinale, Lorenzo Iovino, David Granadier, Colton W. Smith, et al.stimulated with ATP (100 µM, Tocris 3312), HMGB1 (1 µg/ml, Abcam, ab78940), IL1a (50 ng/ml, Tocris, 400-ML-005/CF), IL-33 (50 ng/ml, Tocris, 3626-ML-010/CF), uric acid (50 µg/ml, Sigma, U2625), dsDNA (370 ng), or mtDNA

(5) SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic CancerCancer ResApril 15, 2025Eloise G. Lloyd, Muntadher Jihad, Judhell S. Manansala, Wenlong Li, Priscilla S.W. Cheng, Gianluca Mucciolo, Marta Zaccaria, Sara Pinto Teles, Joaquín Araos Henríquez, Sneha Harish, et al.human TGF-β1 (T7039-2UG; Sigma), 2 μM A83-01 (SML0788; Sigma), 10 ng/mL interleukin 1 alpha (IL-1α, 400-ML-005/CF; R&D Systems), 3-5 μg/mL IL-1α-neutralizing antibody (MAB4001; R&D Systems; RRID:AB_2124216) or IgG

(6) SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic CancerCancer ResearchJanuary 22, 2025Eloise G. Lloyd, Muntadher Jihad, Judhell S. Manansala, Wenlong Li, Priscilla S. W. Cheng, Gianluca Mucciolo, Marta Zaccaria, Sara Pinto Pinto Teles, Joaquín Araos Araos Henríquez, Sneha Harish, et al.human TGF-β1 (T7039-2UG; Sigma), 2 μM A83-01 (SML0788; Sigma), 10 ng/mL interleukin 1 alpha (IL-1α, 400-ML-005/CF; R&D Systems), 3-5 μg/mL IL-1α-neutralizing antibody (MAB4001; R&D Systems; RRID:AB_2124216) or IgG

(7) Vaccine-elicited IL-1R signaling results in Th17 TRM-mediated immunityCommunications biologyApril 9, 2024Hoffmann JP, Srivastava A, Yang H, Iwanaga N, Remcho TP, Hewes JL, Sharoff R, Song K, Norton EB, Kolls JK, et al.methodologies2,33. Recombinant IL-1α and IL-1β used as adjuvants were purchased from R&D Systems (Cat #400-ML-005/CF and 401-ML-010/CF). Mice were vaccinated following the timeline and dosing as described previously 3.

(8) An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesisNatureJanuary 1, 2024LaMarche NM, Hegde S, Park MD, Maier BB, Troncoso L, Le Berichel J, Hamon P, Belabed M, Mattiuz R, Hennequin C, et al.cytokines: CCL3 (Peprotech, ref # 250-09), Csf2 (Peprotech, ref # 315-03), IL-1α (R&D Systems, ref # 400-ML-005/CF), IL-6 (Peprotech, ref # 216-16), IL-7 (Peprotech, ref # 217-17), IL-15 (Peprotech, ref # 210-15), IL-18

(9) Damage-induced pyroptosis drives endogenous thymic regeneration via induction of Foxn1 by purinergic receptor activationbioRxivJanuary 25, 2023Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Antonella Cardinale, Lorenzo Iovino, Paul deRoos, Kayla S. Hopwo, Colton W. Smith, David Granadier, Lucas B. Sullivan, et al.stimulated with ATP (100 μM, Tocris 3312), HMGB1 (1 μg/ml, Abcam, ab78940), IL1a (50 ng/ml,Tocris, 400-ML-005/CF), IL-33 (50 ng/ml, Tocris, 3626-ML-010/CF), or uric acid (50 μg/ml, Sigma, U2625) for 20 h and lysed

(10) Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancerCancer cellJune 13, 2022Huang H, Wang Z, Zhang Y, Pradhan RN, Ganguly D, Chandra R, Murimwa G, Wright S, Gu X, Maddipati R, et al.(CHO derived),PeproTech,Cat# 100-21C Recombinant Mouse IL-1 alpha/IL-1F1 Protein,R&D Systems,Cat# 400-ML-005/CF Gibco Dispase,Thermo Fisher Scientific,Cat# 17-105-041 Collagenase IV,Thermo Fisher Scientific,Cat#

(11) Augmented secretion of IL-1α from mouse oral squamous cell carcinoma (OSCC) vcells caused by serum deprivation and hypoxia promotes immune suppressive activity of mesenchymal stromal cellsJournal of oral biosciencesSeptember 1, 2021Matsunami A, Mizuno-Kamiya M, Kawaki H, Takayama E, Ueno K, Ando M, Morimoto-Ito H, Muramatsu Y, Sumitomo S, Kondoh N.

(12) Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic strokeJournal of neuroinflammationNovember 14, 2019Salmeron KE, Maniskas ME, Edwards DN, Wong R, Rajkovic I, Trout A, Rahman AA, Hamilton S, Fraser JF, Pinteaux E, et al.

(13) Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancerEMBO molecular medicineNovember 7, 2019Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid MM, Toombs J, Du W, Wright S, Hagopian M, Wang Z, et al.Anti‐CD335 (137604) antibody and recombinant mouse IL‐6 (575704) were obtained from BioLegend. Mouse (400‐ML‐005/CF) and human (200‐LA‐002/CF) IL‐1α, mouse IL‐6 (DY406), mouse LIF (DY449), and human IL‐6 (DY206) DuoSet

(14) IL-22 Binding Protein Promotes the Disease Process in Multiple SclerosisJournal of immunology (Baltimore, Md. : 1950)August 15, 2019Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, Lindén M, Abdelmagid N, Tandre K, Hollins C, Irving L, Glover C, et al.

(15) Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensisPLoS pathogensAugust 1, 2019Ketelut-Carneiro N, Souza COS, Benevides L, Gardinassi LG, Silva MC, Tavares LA, Zamboni DS, Silva JS.

(16) IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal AdenocarcinomaCancer discoveryFebruary 1, 2019Biffi G, Oni TE, Spielman B, Hao Y, Elyada E, Park Y, Preall J, Tuveson DA.transplantation experiments. Drug and antibody treatments. Cells were treated with 0.1 or 1 ng/mL mouse (400-ML-005/CF, R&D Systems) or human (200-LA-002/CF, R&D Systems) IL-1α, 1 ng/mL mouse IL-1β (401-ML-005/CF, R&D Systems),

(17) GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease InductionJournal of immunology (Baltimore, Md. : 1950)February 1, 2018Duncker PC, Stoolman JS, Huber AK, Segal BM.

(18) Administration of Interleukin-35-Conditioned Autologous Tolerogenic Dendritic Cells Prolong Allograft Survival After Heart TransplantationCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2018Liu X, Sun Y, Zheng Y, Zhang M, Jin X, Kang K, Wang Y, Li S, Zhang H, Zhao Q, et al.

(19) LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 ProductionJournal of immunology (Baltimore, Md. : 1950)February 1, 2016Jiang H, Promchan K, Lin BR, Lockett S, Chen D, Marshall H, Badralmaa Y, Natarajan V.

(20) The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce OsteoclastogenesisThe Journal of biological chemistrySeptember 25, 2015Jules J, Wang S, Shi Z, Liu J, Wei S, Feng X.

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IL-1 alpha/IL-1F1 Protein

IL-1 alpha/IL-1F1 Protein

IL-1 alpha/IL-1F1 Protein

IL-1 alpha/IL-1F1 Protein

IL-1 alpha/IL-1F1 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (34)

Reviews

IL-1 alpha/IL-1F1 Protein from R&D Systems, a Bio-Techne Brand

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