Recombinant Human Tie-2 Fc Chimera Protein, CF 313-TI-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Tie-2 Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $471.00Supplier Page View Company Product Page
Catalog Number313-TI-100
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS
Molecule NameTie-2
Size100 ug
NCBI Full Gene NameTEK receptor tyrosine kinase
NCBI Gene AliasesVMCM1, VMCM, GLC3E, TIE2, CD202B, TIE-2
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 135 kDa, reducing conditions
Theoretical: 100 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Tie-2 Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) An engineered tetra-valent antibody fully activates the Tie2 receptor with comparable potency to its natural ligand angiopoietin-1Scientific reportsJuly 7, 2021Koya Y, Nara H, Yagi S, Ueno C, Kamohara M.

(2) Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retinaeLifeNovember 16, 2018Elamaa H, Kihlström M, Kapiainen E, Kaakinen M, Miinalainen I, Ragauskas S, Cerrada-Gimenez M, Mering S, Nätynki M, Eklund L.

(3) Angiopoietin-1 is required for Schlemm's canal development in mice and humansThe Journal of clinical investigationDecember 1, 2017Thomson BR, Souma T, Tompson SW, Onay T, Kizhatil K, Siggs OM, Feng L, Whisenhunt KN, Yanovitch TL, Kalaydjieva L, et al.was collected and mixed with 1 μg of recombinant human TEK2-Fc protein (Ala23-Lys745; R&D Systems; 313-TI-100) and incubated for 1 hour. Then, protein A beads blocked with 5% BSA solution were added to the medium

(4) Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapyOncotargetMay 16, 2017Shlamkovich T, Aharon L, Barton WA, Papo N.

(5) Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial CellsPloS oneJanuary 1, 2016Chan W, Ismail H, Mayaki D, Sanchez V, Tiedemann K, Davis EC, Hussain SN.Fibulin-5. Full-length recombinant Fibulin-5, recombinant human Tie-2/Fc chimera (R&D Systems, Cat.# 313-TI-100) or recombinant Ang-1 (R&D, Cat. #923-AN/CF) were coated overnight at 4°C onto 96-well plates (Nalge

(6) Angiopoietin1 inhibits mast cell activation and protects against anaphylaxisPloS oneJanuary 1, 2014Yao JH, Cui M, Li MT, Liu YN, He QH, Xiao JJ, Bai Y.

(7) Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expressionmAbsMarch 1, 2013Buchanan A, Clementel V, Woods R, Harn N, Bowen MA, Mo W, Popovic B, Bishop SM, Dall'Acqua W, Minter R, et al.

(8) Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contactsNature cell biologyMay 1, 2008Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, Nottebaum A, Vestweber D, Deutsch U, Koh GY, et al.

(9) Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2Molecular biology of the cellDecember 1, 2006Masckauchán TN, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li CM, Khoo A, Tycko B, Brown AM, Kitajewski J.

(10) Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentationThe Journal of clinical investigationOctober 1, 2006Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, et al.

(11) Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependentArteriosclerosis, thrombosis, and vascular biologyApril 1, 2006Zhu T, Sennlaub F, Beauchamp MH, Fan L, Joyal JS, Checchin D, Nim S, Lachapelle P, Sirinyan M, Hou X, et al.

(12) Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabodyCancer researchFebruary 1, 2005Popkov M, Jendreyko N, McGavern DB, Rader C, Barbas CF 3rd.

(13) Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2Cancer cellNovember 1, 2004Oliner J, Min H, Leal J, Yu D, Rao S, You E, Tang X, Kim H, Meyer S, Han SJ, et al.

(14) Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier propertiesJournal of the American Society of Nephrology : JASNMarch 1, 2004Satchell SC, Anderson KL, Mathieson PW.

(15) Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1European journal of clinical investigationOctober 1, 2003Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY.

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Tie-2 Fc Chimera Protein

Tie-2 Fc Chimera Protein

Recombinant Human Tie-2 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Tie-2 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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