Recombinant Human TGF-beta 1 Protein, CF 240-B-002/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human TGF-beta 1 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $351.00Supplier Page View Company Product Page
Catalog Number240-B-002/CF
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA
Molecule NameTGF-beta 1
Source/Expression SystemCHO-derived Recombinant Human TGF-beta 1 Protein, CF
Size2 ug (also 10 ug, 500 ug, 1 mg)
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 12 kDa, reducing conditions 24 kDa, non-reducing conditions
Theoretical: 12.8 kDa (monomer)
NCBI Full Gene Nametransforming growth factor beta 1
NCBI Gene AliasesTGF-beta1, TGFB, DPD1, TGFbeta, CED, IBDIMDE, LAP
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Conjugate/TagUnconjugated
ApplicationsBioactivity

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Cell type–dependent role of transforming growth factor-β signaling on postnatal neural stem cell proliferation and migrationNeural Regeneration ResearchMarch 1, 2026Kierra Ware, Joshua Peter, Lucas McClain, Yu Luoethanol,Sigma,493546-1L "2,2,2-Tribromoethanol",Sigma,T48402-25G 2-Methyl-2-butanol,Sigma,240486-100ml DAPI,Sigma,D9542 SB-431542,Sigma,S4317 TGF-β1,"R & D Systems, Minneapolis, MN, USA",240-B-002/CF Software,, ImageJ,"NIH, Bethesda, MD, USA",https://doi.org/10.1038/nmeth.2089RRID: SCR_003070 Zen

(2) ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogrammingInternational Journal of Biological SciencesJanuary 1, 2026Sibei Tao, Chenzhou Wu, Fanyuan Yu, Lina Yang, Lingzhi Li, Fan Guo, Ting Xiang, Liang Ma, Ping Fu(SH30084.03, Hyclone, Beijing, China) for 24 h, then further treated with 20 ng/mL of TGF-β1 (R&D Systems, 240-B-002/CF, Minneapolis, MN, USA). Tail vein injection of adeno-associated virus (AAV) Mice were fixed with a

(3) The recombinant zoster vaccine induces trained immunity in monocytes through persistent downregulation of TGFβPLoS PathogDecember 5, 2025Michael J. Johnson, Megan Crotteau, Debashis Ghosh, Thao Vu, Luke Trinity, Radu Marches, Duygu Ucar, Myron J. Levin, Adriana Weinbergµg/ml, and day 90 post-vaccination cocultures with recombinant human TGF-beta 1 protein (R&D Systems; 240-B-002/CF) at a concentration of 0.1 ng/ml in the presence of rgE or unstimulated control. All cultures were incubated

(4) Generation of a novel lung fibrosis model using precision-cut lung slices from transgenic TGFβ1 miceAmerican Journal of Physiology-Cell PhysiologyAugust 1, 2025Yanzhe Liu, Paris C. Papagianis, Zifra S. C. de Kuijper, Julia G. Chitty, Belinda Thomas, Theo Borghuis, Rianne M. Jongman, Janesh Pillay, Elizabeth A. Richards, Barbro N. Melgert, et al.Systems; 5 μM PDGF-AB, PHG0134, GIBCO; and 5 μM LPA, 62215, Cayman), or TGFβ1 5ng/ml (exogenous TGFβ1, 240-B-002/CF, R&D Systems). All FC components were used as described previously19, but excluding 5 ng/ml TGFβ1. We

(5) Aberrant EZHIP expression drives tumorigenesis in osteosarcomaNat CommunJuly 22, 2025Wajih Jawhar, Geoffroy Danieau, Alva Annett, Takeaki Ishii, Andrea Bajic, Ana Castillo-Orozco, Brian Krug, Yara Faucher-Jabado, Justin Seyedmoomenkashi, Mostafa Saquib, et al.8-well chamber slides and induced the following day with a cocktail of 5 ng/mL TGF-β1 (R&D systems, 240-B-002/CF), 30μM L-Ascorbic acid 2-phosphate (Sigma, A8960), 5 ng/mL PDGF-AB (Peprotech, 100-00AB). Media was

(6) Paracrine regulation of pancreatic cancer cell response to chemotherapy by GLI2-collagen I signalingThe Journal of biological chemistryJuly 1, 2025Vera RE, Fernandez-Barrena MG, Falero JM, Kwon JY, Garza RA, Sigafoos AN, Ross MD, Toruner MD, Toruner M, Tolosa EJ, et al.CO2. TGFβ1 treatment For TGFβ1 treatment, 20 ng/ml (HPSC) or 4 ng/ml (MRC-5) TGFβ1 recombinant ligand (240-B-002/CF; R&D Systems) was added to cells in complete media. Samples were collected 24 h after treatment for

(7) TGF-β signaling controls neural crest developmental plasticity via SMAD2/3Developmental CellJune 23, 2025Megan Rothstein, Ana Paula Azambuja, Tatiane Y. Kanno, Catriona Breen, Marcos Simoes-Costawith either 3μM CHIR99021 (Tocris, 4423) +/− 5ng/mL recombinant human TGF-beta 1 protein (R&D Systems, 240-B-002/CF) or 10μM SB431542 (Sigma-Aldrich, S4317); or with 10μM CHIR99021 +/− 5ng/mL recombinant hTGFβ1 protein

(8) Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activityMaterials Today BioJune 1, 2025Chen-Yi Liao, Jasmijn H.M. Hundscheid, Justin Crawford, Peter ten Dijke, Beatrice Coornaert, Erik H.J. Danenfibroblast cultures were plated in DMEM with 2 % FBS (NF) or in DMEM with 2 % FBS and 10 ng/ml TGFβ (TGFβ1; 240-B-002/CF; R&D Systems; AF) and incubated for 72 h. Subsequently, the subconfluent monolayers of NF or AF were

(9) Development and characterization of AD-214, an anti-CXCR4 i-body-Fc fusion for the treatment of idiopathic pulmonary fibrosisMAbsMay 21, 2025Jason P. Lynch, Louise Organ, Khamis Tomusange, Lukasz Kowalczyk, Dallas J. Hartman, Angus Tester, Chris Hosking, Michael Foley0.1% FBS (GIBCO) as previously published.63 Fibrotic cocktail consisted of 5 ng/ml recombinant TGF-ß (240-B-002/CF, R&D Systems), 10 ng/mL PDGF-AB (PHG0134, GIBCO), 10 ng/ml TNF (P6804, R&D Systems), and 5 µM LPA (62215,

(10) Indole-3-propionic acid promotes hepatic stellate cells inactivationJ Transl MedMarch 1, 2025Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kaminska, Shrey Gandhi, Ville Männistö, Charlotte Ling, Stefano Romeo, Päivi Pajukanta, et al.the capacity of IPA to inactivate HSCs, LX-2 cells were co-treated with 5 ng/ml TGF-β1 (R&D systems, 240‐B‐002/CF) and 1 mM IPA in serum-free media for 24 h. For the corresponding vehicle control, 4 nM HCL with 0.1%

(11) Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studiesRespir ResFebruary 17, 2025M. Camila Melo-Narvaez, Fee Gölitz, Eshita Jain, Janine Gote-Schniering, Mircea Gabriel Stoleriu, Wilhelm Bertrams, Bernd Schmeck, Ali Önder Yildirim, Ursula Rauen, Timo Wille, et al.previously described [2]. Transforming growth factor-β1 (TGF-β1) was obtained from R&D systems (Product ID: 240-B-002/CF), reconstituted in 0.1% Bovine Serum Albumin (BSA, Sigma) dissolved in 4 mM HCl in Phosphate Buffered

(12) Phenomics Demonstrates Cytokines Additive Induction of Epithelial to Mesenchymal TransitionJournal of Cellular PhysiologyNovember 20, 2024Alphonse Boché, Alexandra Landras, Mathieu Morel, Sabrina Kellouche, Franck Carreiras, Ambroise Lambertas control, a concentration of 10 ng/mL of TNF‐α, a concentration of 10 ng/mL of TGFβ1 (R&D Systems,240‐B‐002/CF), or TNF‐α (R&D Systems, 210‐TA‐005/CF) and TGFβ1 at 10 ng/mL each. The carrier free cytokines were

(13) The Role of TGF-β1 and Mutant SMAD4 on Epithelial-Mesenchymal Transition Features in Head and Neck Squamous Cell Carcinoma Cell LinesCancersSeptember 16, 2024Bette M, Reinhardt L, Gansukh U, Xiang-Tischhauser L, Meskeh H, Di Fazio P, Buchholz M, Stuck BA, Mandic R.the cell index (CI) at 15 min intervals for at least 120 hr. TGF-β1 (recombinant human TGF-β1, cat# 240-B-002/CF, Bio-Techne, Minneapolis, MN, USA) was added to a final concentration of 10 ng/mL and the respective

(14) Trained Immunity Generated by the Recombinant Zoster VaccineResearch squareJuly 10, 2024Weinberg A, Johnson M, Crotteau M, Ghosh D, Vu T, Levin MJ.μg/ml, and day 90 postvaccination cocultures with recombinant human TGF-beta 1 protein (R&D Systems; 240-B-002/CF) at a concentration of 0.1 ng/ml in the presence of rgE or unstimulated control. Cultures were incubated

(15) RNA-sequencing reveals differential fibroblast responses to bleomycin and pneumonectomyPhysiological reportsJuly 1, 2024Wellmerling JH, Dresler SR, Meridew JA, Choi KM, Tschumperlin DJ, Tan Q.III cDNA synthesis kit (Thermo Fisher Scientific, #11754050). Recombinant human TGF‐β1 (R&D Systems, #240‐B‐002/CF) was added at a final concentration of 10 ng/mL. 2‐APB (Tocris, #1224) was added at a concentration

(16) Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue modelF1000ResearchFebruary 12, 2024Max J Cumberland, Jonas Euchner, Amar J Azad, Nguyen T N Vo, Paulus Kirchhof, Andrew P Holmes, Chris Denning, Katja Gehmlichsupplemented with 10 ng/mL FGF2 + 10 μM SB 431542 or 10 ng/mL FGF2 + 10 ng/mL TGF-β1 (R&D Systems, 240-B-002/CF). RNA extraction was performed using the Direct-zol RNA Miniprep Kit (Zymo Research, R2050) according

(17) Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitisbioRxiv : the preprint server for biologyOctober 19, 2023Min K, Yenilmez B, Kelly M, Echeverria D, Elleby M, Lifshitz LM, Raymond N, Tsagkaraki E, Harney SM, DiMarzio C, et al.

(18) Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoidsLife Science AllianceAugust 1, 2023Victoria Ptasinski, Susan J Monkley, Karolina Öst, Markus Tammia, Hani N Alsafadi, Catherine Overed-Sayer, Petra Hazon, Darcy E Wagner, Lynne A Murrayalveolospheres were stimulated with the addition of the FC consisting of 5 ng/ml recombinant TGF-β (240-B-002/CF; R&D Systems), 10 ng/ml PDGF-AB (PHG0134; GIBCO), 10 ng/ml TNF-α (410-MT-010/CF; GIBCO), and 5 μM lysophosphatidic

(19) LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lungScience advancesMay 26, 2023Ma HY, Li Q, Wong WR, N'Diaye EN, Caplazi P, Bender H, Huang Z, Arlantico A, Jeet S, Wong A, et al.

(20) Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B CellsInternational journal of molecular sciencesApril 13, 2023Krizanac M, Mass Sanchez PB, Schröder SK, Weiskirchen R, Asimakopoulos A.human TNF-α (#210-TA-005/CF, R&D Systems, Wiesbaden, Germany), 2.5 ng/mL of recombinant human TGF-β (#240-B-002/CF, R&D Systems), 2.5 ng/mL of recombinant human IL-1β (#HZ-1164, Miltenyi Biotech., Bergisch Gladbach,

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TGF-beta 1 Protein

Recombinant Human TGF-beta 1 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human TGF-beta 1 Protein, CF from R&D Systems, a Bio-Techne Brand

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