Recombinant Mouse IL-6R alpha (aa 20-357) Protein 1830-SR-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse IL-6R alpha (aa 20-357) Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $454.00Supplier Page View Company Product Page
Catalog Number1830-SR-025
SpeciesMouse
Molecule NameIL-6R alpha
Size25 ug
NCBI Full Gene Nameinterleukin 6 receptor, alpha
NCBI Gene AliasesIL-6R-alpha, CD126, Il6r, IL-6R, IL-6RA
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 60-66 kDa, reducing conditions
Theoretical: 39 kDa (monomer)
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse IL-6R alpha (aa 20-357) Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Targeting IL6-Edn1-FoxO1 axis enables lung growth in mechanically ventilated newborn miceEuropean Respiratory JournalDecember 4, 2025Dharmesh Hirani, Jaco Selle, Virta Wagde, Oleksiy Klymenko, Celien Kuiper-Makris, Soula Danopoulos, Michele Donato, Stefanie Preuss, Mark Preuss, Sana Mujahid, et al.were treated with 1) 100 ng IL-6 (Sigma-Aldrich; #I9646)+20 ng IL-6Ra (IL-6Ra Protein; R&D Systems; #1830-SR-025; IL 6/sIL-6R) or 2) 100 nM of recombinant endothelin 1 (Phoenix Pharmaceuticals Inc; #023-01). The mRNA

(2) Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later lifeNature communicationsJuly 27, 2022Selle J, Dinger K, Jentgen V, Zanetti D, Will J, Georgomanolis T, Vohlen C, Wilke R, Kojonazarov B, Klymenko O, et al.

(3) An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexiaProceedings of the National Academy of Sciences of the United States of AmericaMarch 1, 2022Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, Schauer S, Baumgartner VJ, Grabner GF, Schabbauer G, et al.

(4) The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cellsImmunityFebruary 9, 2021Yousif AS, Ronsard L, Shah P, Omatsu T, Sangesland M, Bracamonte Moreno T, Lam EC, Vrbanac VD, Balazs AB, Reinecker HC, et al.,R&D systems,Cat#406-ML-005 Murine recombinant IL-6-IL6Rα,R&D systems,Cat#9038-SR-025 Murine recombinant IL6R,R&D systems,Cat#1830-SR-025 Diphtheria toxin (DT),Sigma,Cat#D0564 Streptavidin conjugated APC,ThermoFisher,Cat# S32362 ,, Critical

(5) Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activationTheranosticsJanuary 1, 2019Chen W, Yuan H, Cao W, Wang T, Chen W, Yu H, Fu Y, Jiang B, Zhou H, Guo H, et al.

(6) The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expressionThe Journal of biological chemistrySeptember 29, 2017Foreman HC, Armstrong J, Santana AL, Krug LT, Reich NC.

(7) Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistanceNature communicationsMay 3, 2017Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC.R&D Systems), 200 ng ml−1 IL-6—IL-6Rα complex (9038-SR-025, R&D Systems) or 130 ng ml−1 sIL-6Rα alone (1830-SR-025, R&D Systems). After stimulation (20 min), cells were pelleted and stained for extracellular markers

(8) Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1Nature methodsMay 1, 2017Shukla S, Langley MA, Singh J, Edgar JM, Mohtashami M, Zúñiga-Pflücker JC, Zandstra PW.

(9) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylationMolecular and cellular endocrinologyJanuary 15, 2017Mancini SJ, White AD, Bijland S, Rutherford C, Graham D, Richter EA, Viollet B, Touyz RM, Palmer TM, Salt IP.

(10) Temporal expression of growth factors triggered by epiregulin regulates inflammation developmentJournal of immunology (Baltimore, Md. : 1950)February 1, 2015Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, et al.

(11) The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormoneThe Journal of biological chemistryMarch 8, 2013Cho SW, Pirih FQ, Koh AJ, Michalski M, Eber MR, Ritchie K, Sinder B, Oh S, Al-Dujaili SA, Lee J, et al.

(12) Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in miceJournal of immunology (Baltimore, Md. : 1950)May 1, 2012Wunderlich CM, Delić D, Behnke K, Meryk A, Ströhle P, Chaurasia B, Al-Quraishy S, Wunderlich F, Brüning JC, Wunderlich FT.

(13) CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitisJournal of neuroinflammationJanuary 23, 2012Roy M, Richard JF, Dumas A, Vallières L.

(14) Effect of arachidonic acid on hypoxia-induced IL-6 production in mouse ES cells: Involvement of MAPKs, NF-kappaB, and HIF-1alphaJournal of cellular physiologyMarch 1, 2010Lee SH, Lee YJ, Han HJ.

(15) Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma-induced CD40 in murine microgliaJournal of NeuroinflammationDecember 1, 2009Hsiao-Wen Lin, Mohit Raja Jain, Hong Li, Steven W LevisonIsrael), and recombinant mouse IL-6 (rmIL-6, 406-ML-005), recombinant mouse IL-6 receptors (rmIL-6R, 1830-SR-025), recombinant mouse interferon-γ (rmIFNγ, 485-MI-100) and recombinant mouse granulocyte-macrophage colony-stimulating

(16) Sequential ELISA to profile multiple cytokines from small volumesJournal of immunological methodsJuly 1, 2005Osuchowski MF, Siddiqui J, Copeland S, Remick DG.

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IL-6R alpha Protein

IL-6R alpha Protein

Recombinant Mouse IL-6R alpha (aa 20-357) Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse IL-6R alpha (aa 20-357) Protein from R&D Systems, a Bio-Techne Brand

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