Recombinant Human GDF-15 Protein, CF 957-GD-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human GDF-15 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $428.00Supplier Page View Company Product Page
Catalog Number957-GD-025/CF
Size25 ug
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity not tested
Conjugate/TagUnconjugated
SpeciesHuman
Molecule NameGDF-15
Source/Expression SystemCHO-derived Recombinant Human GDF-15 Protein, CF
Molecular WeightObserved: 14 kDa, reducing conditions
Theoretical: 13 kDa (monomer)
NCBI Full Gene Namegrowth differentiation factor 15
NCBI Gene AliasesGDF-15, NAG-1, MIC1, PTGFB, MIC-1, PDF, PLAB
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Sustained alternate-day fasting potentiates doxorubicin cardiotoxicityCell metabolismJune 6, 2023Ozcan M, Guo Z, Valenzuela Ripoll C, Diab A, Picataggi A, Rawnsley D, Lotfinaghsh A, Bergom C, Szymanski J, Hwang D, et al.animal experiments with Dox. Recombinant human GDF15 (25 μg) was purchased from Biotechne/R&D Systems (Cat#957-GD-025/CF, Minneapolis, MN, USA) and was reconstituted in 250 μl of 4 mM HCl to get a 0.1 μg/μl stock, stored

(2) A brainstem circuit for nausea suppressionCell reportsJune 14, 2022Zhang C, Vincelette LK, Reimann F, Liberles SD.saline (10 μL/g, IP) alone or containing either CNO (1 mg/kg, Tocris 6329), GDF15 (20 μg/kg, R&D systems 957-GD-025/CF), [D-Ala2]-GIP (374 μg/kg), or LiCl (168 mg/kg). On day five (recovery day), both water bottles contained

(3) Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcomaEndocrine journalJanuary 28, 2020Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, Nishimura K, Yamada M, Miyamoto K, Yoshida Y.

(4) Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndromeJournal of translational medicineDecember 4, 2019Melvin A, Lacerda E, Dockrell HM, O'Rahilly S, Nacul L.

(5) Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15)International journal of molecular sciencesJanuary 4, 2019Gkretsi V, Louca M, Stylianou A, Minadakis G, Spyrou GM, Stylianopoulos T.

(6) Reduced oxidative capacity in macrophages results in systemic insulin resistanceNature communicationsApril 19, 2018Jung SB, Choi MJ, Ryu D, Yi HS, Lee SE, Chang JY, Chung HK, Kim YK, Kang SG, Lee JH, et al.

(7) An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cellsOncotargetApril 11, 2017Sasahara A, Tominaga K, Nishimura T, Yano M, Kiyokawa E, Noguchi M, Noguchi M, Kanauchi H, Ogawa T, Minato H, et al.

(8) GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathwayOncotargetJanuary 3, 2017Li YL, Chang JT, Lee LY, Fan KH, Lu YC, Li YC, Chiang CH, You GR, Chen HY, Cheng AJ.

(9) TGF-β contamination of purified recombinant GDF15PloS oneJanuary 1, 2017Olsen OE, Skjærvik A, Størdal BF, Sundan A, Holien T.

(10) Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork CellsInvestigative ophthalmology & visual scienceDecember 1, 2016Muralidharan AR, Maddala R, Skiba NP, Rao PV.insight into the role of GDF-15 in TM cells, we evaluated initially the effects of human rGDF-15 (C.No. 957-GD-025/CF; R&D Systems, Inc.) on gene expression by cDNA microarray analysis. The Affymetrix GeneChip Human Genome

(11) GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body DementiaPloS oneJanuary 1, 2016Maetzler W, Deleersnijder W, Hanssens V, Bernard A, Brockmann K, Marquetand J, Wurster I, Rattay TW, Roncoroni L, Schaeffer E, et al.

(12) Macrophage inhibitory cytokine 1 biomarker serum immunoassay in combination with PSA is a more specific diagnostic tool for detection of prostate cancerPloS oneJanuary 1, 2015Li J, Veltri RW, Yuan Z, Christudass CS, Mandecki W.

(13) Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1British journal of cancerMarch 19, 2013Mimeault M, Johansson SL, Batra SK.

(14) GDF-15 prevents platelet integrin activation and thrombus formationJournal of thrombosis and haemostasis : JTHFebruary 1, 2013Rossaint J, Vestweber D, Zarbock A.

(15) Growth differentiation factor-15 suppresses maturation and function of dendritic cells and inhibits tumor-specific immune responsePloS oneJanuary 1, 2013Zhou Z, Li W, Song Y, Wang L, Zhang K, Yang J, Zhang W, Su H, Zhang Y.

(16) Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growthThe Journal of biological chemistryAugust 26, 2011Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, et al.

(17) Wild-type p53 attenuates cancer cell motility by inducing growth differentiation factor-15 expressionEndocrinologyAugust 1, 2011Cheng JC, Chang HM, Leung PC.

(18) Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factorsThe Journal of clinical investigationFebruary 1, 2011Schledzewski K, Géraud C, Arnold B, Wang S, Gröne HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, et al.

(19) Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genesPloS oneJanuary 1, 2011Si Y, Liu X, Cheng M, Wang M, Gong Q, Yang Y, Wang T, Yang W.

(20) Macrophage inhibitory cytokine-1 regulates melanoma vascular developmentThe American journal of pathologyJune 1, 2010Huh SJ, Chung CY, Sharma A, Robertson GP.

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Recombinant Human GDF-15 Protein, CF

GDF-15 Protein

Recombinant Human GDF-15 Protein, CF from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Recombinant Human GDF-15 Protein, CF from R&D Systems, a Bio-Techne Brand

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