Recombinant Human/Mouse Wnt-5a Protein 645-WN-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human/Mouse Wnt-5a Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $716.00Supplier Page View Company Product Page
Catalog Number645-WN-010
Size10 ug
ApplicationsBioactivity
FormatLyophilized from a 0.2 µm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein
Purity>80%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 45 kDa, reducing conditions
Theoretical: 38 kDa
Conjugate/TagUnconjugated
SpeciesHuman, Mouse
Molecule NameWnt-5a
Source/Expression SystemCHO-derived Recombinant Human/Mouse Wnt-5a Protein
NCBI Full Gene Namewingless-type MMTV integration site family, member 5A, Wnt family member 5A
NCBI Gene AliaseshWNT5A, 8030457G12Rik, Wnt-5a
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Dishevelled PDZ domain targeting peptides modulate non-canonical Wnt5a/Ror signalingBiochem Biophys RepApril 30, 2026Andrew C. Jubintoro, Ho-Jin Lee, Hsin-Yi Henry Ho, Jie J. ZhengDPBS with 0.5% FBS. Flow cytometry was performed on a Sony MA900 Cell Sorter. Wnt5a (Bio-Techne, Cat#645-WN-010) was dissolved in DPBS with 0.1% BSA and 0.5% w/v CHAPS. Gating of live cell population via side scatter

(2) Distinct radial glia subtypes regulate midbrain dopaminergic neuron developmentNature NeuroscienceFebruary 16, 2026Emilía Sif Ásgrímsdóttir, Luca Fusar Bassini, Ting Sun, Clàudia Puigsasllosas Pastor, Pia Rivetti di Val Cervo, Daniel Gyllborg, Kawai Lee, Christopher L. Grigsby, Baptiste Jude, Carmen Abaurre, et al.ligand testing, cells were cultured in maturation media(cit) supplemented with WNT5A (100 ng ml−1; R&D, 645-WN-010), IWP2 (10 µM; Tocris, 3533), Valsartan (10 µM; Sigma-Aldrich, SML0142), AngII (100 nM; Sigma-Aldrich,

(3) YAP as a therapeutic target to reverse trastuzumab resistanceGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer AssociationSeptember 1, 2025Nam AR, Oh KS, Bang JH, Jeong Y, Choo SY, Kim HJ, Lee SI, Kim JM, Yoon J, Kim TY, et al.were purchased from Selleck Chemicals (Houston, TX, USA). Recombinant Human/Mouse Wnt-5a Protein (#645-WN-010) and cycloheximide (#C7698) were purchased from R&D Systems (Minneapolis, MN, USA) and Sigma-Aldrich

(4) Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradientsNature communicationsJuly 22, 2025Buissant des Amorie JR, Betjes MA, Bernink JH, Hageman JH, Geurts VE, Begthel H, Laskaris D, Heinz MC, Jordens I, Vinck T, et al.

(5) WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signalingNature communicationsMay 24, 2025Voss JH, Koszegi Z, Yan Y, Shorter E, Grätz L, Lanner JT, Calebiro D, Schulte G.

(6) Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airwayNature communicationsMay 3, 2025Hu DJ, Cai XT, Simons J, Yun J, Elstrott J, Jasper H.(30 µM, Millipore, SML0203), Verteporfin (10 µM, Selleck Chemical, S178610), Wnt5a (500 ng/ml, Novus, 645-WN-010), and Wnt3a (500 ng/ml, Novus, 1324-WN-010). Immunostaining and histology of tracheal sections Trachea

(7) Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progressionNat CommunApril 17, 2025Akikazu Harada, Yoshiaki Yasumizu, Takeshi Harada, Katsumi Fumoto, Akira Sato, Natsumi Maehara, Ryota Sada, Shinji Matsumoto, Takashi Nishina, Kiyoshi Takeda, et al.D12018). The following recombinant proteins were administered where indicated; Wnt5a (R&D Systems; Cat. 645-WN-010) and Wnt5b (purified as previously described54). Cells were incubated for 6 or 20 h to allow tube formation,

(8) Porcupine inhibition enhances hypertrophic cartilage differentiationJBMR PlusMarch 29, 2025Michael Killinger, Tereza Szotkowská, Denisa Lusková, Nikodém Zezula, Vítězslav Bryja, Marcela BuchtovánM.35 For experiments following the role of Wnt signaling, WNT3a (1324-WN-010; Bio-Techne) or WNT5a (645-WN-010; Bio-Techne) proteins were added to the medium at a concentration of 10 ng/mL either individually or

(9) Wnt signaling drives stromal inflammation in inflammatory arthritisbioRxiv : the preprint server for biologyJanuary 8, 2025Mueller AA, Zou AE, Marsh LJ, Kemble S, Nayar S, Watts GFM, Murphy CL, Taylor E, Major T, Gardner D, et al.

(10) DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineageScientific reportsOctober 31, 2024Chen Y, Petho A, Ganapathy A, George A.

(11) SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formationOpen biologyOctober 1, 2024Dias AP, Rehmani T, Applin BD, Salih M, Tuana B.

(12) Structural insights into Frizzled3 through nanobody modulatorsNature communicationsAugust 22, 2024Hillier J, Zhao Y, Carrique L, Malinauskas T, Ruza RR, Chang TH, Yi G, Duyvesteyn HME, Yu J, Lu W, et al.

(13) Wnt5a Promotes Axon Elongation in Coordination with the Wnt-Planar Cell Polarity PathwayCellsJuly 28, 2024Ahmad S, Attisano L.

(14) Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndromeDisease models & mechanismsJune 1, 2024Tophkhane SS, Fu K, Verheyen EM, Richman JM.

(15) Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signalingeLifeMay 23, 2024Griffiths SC, Tan J, Wagner A, Blazer LL, Adams JJ, Srinivasan S, Moghisaei S, Sidhu SS, Siebold C, Ho HH.

(16) Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer AngiosuppressionCancer discoveryFebruary 8, 2024Hasselluhn MC, Decker-Farrell AR, Vlahos L, Thomas DH, Curiel-Garcia A, Maurer HC, Wasko UN, Tomassoni L, Sastra SA, Palermo CF, et al.

(17) Single-cell RNA sequencing of intestinal crypts reveals vital events in damage repair and the double-edged sword effect of the Wnt3/β-catenin pathway in irradiated miceRedox biologyDecember 1, 2023Yuan T, Zhang J, Zhao Y, Guo Y, Fan S.

(18) Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2Science advancesNovember 24, 2023Colozza G, Lee H, Merenda A, Wu SS, Català-Bordes A, Radaszkiewicz TW, Jordens I, Lee JH, Bamford AD, Farnhammer F, et al.

(19) Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinomabioRxivNovember 10, 2023Jiawen Yang, James T Lim, Paul Victor, Chen Chen, Hunain Khwaja, Rick G Schnellmann, Denise J Roe, Prafulla C Gokhale, James A DeCaprio, Megha Padinumber Pyrvinium pamoate,MedChemExpress,MFCD00010090 Nutlin-3a,Selleck Chemicals,S8059 WNT5A,R&D systems Inc,645WN010 WNT5B,R&D systems Inc,7347WN025 Tunicamycin,Sigma-Aldrich,T7765 Thapsigargin,Sigma-Aldrich,T9033 Reagents

(20) ROR2 homodimerization is sufficient to activate a neuronal Wnt/calcium signaling pathwayThe Journal of biological chemistryNovember 1, 2023Riquelme R, Li L, Gambrill A, Barria A.36 h. When indicated, cells were stimulated with either 250 ng/ml of recombinant Wnt5a (R&D Systems, 645-WN-010) or 10 μm rapamycin (LC Labs, R-5000). DNA plasmids and constructs All ROR2 constructs used are from

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Wnt-5a Protein

Wnt-5a Protein

Recombinant Human/Mouse Wnt-5a Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human/Mouse Wnt-5a Protein from R&D Systems, a Bio-Techne Brand

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