Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein 315-BR-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human BMPR-IA/ALK-3 Fc Chimera Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $555.00Supplier Page View Company Product Page
Catalog Number315-BR-100
SpeciesHuman
Molecule NameBMPR-IA/ALK-3
Size100 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 55 kDa, reducing conditions
Theoretical: 41.5 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Namebone morphogenetic protein receptor type 1A
NCBI Gene Aliases10q23del, ACVRLK3, ALK-3, ALK3, BMPR-1A, CD292, SKR5

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(1) BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiationJournal of cell scienceAugust 21, 2020Mang T, Kleinschmidt-Doerr K, Ploeger F, Schoenemann A, Lindemann S, Gigout A.

(2) Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cellsJournal of leukocyte biologyApril 1, 2015Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, Haniffa M, Collin M.initially and after 18 h. Recombinant human BMPR-IA/ALK-3 Fc chimera was obtained from R&D Systems (315-BR-100) and used at 2 μg/ml. qPCR RNA was extracted from sorted cell populations or LCH lesions by use of

(3) The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and HomeostasisPloS oneJanuary 1, 2015Martínez VG, Sacedón R, Hidalgo L, Valencia J, Fernández-Sevilla LM, Hernández-López C, Vicente A, Varas A.

(5) Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpressionBloodNovember 28, 2013Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, Ffrench M, Salesse S, Nicolini FE, Maguer-Satta V.

(6) Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growthThe Journal of biological chemistryAugust 26, 2011Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, et al.

(7) Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammationBloodMay 5, 2011Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, et al.

(8) BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signalingBloodOctober 15, 2008Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V.

(9) A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7Journal of molecular biologySeptember 12, 2008Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.

(12) Specification of dorsal telencephalic character by sequential Wnt and FGF signalingNature neuroscienceJuly 1, 2003Gunhaga L, Marklund M, Sjödal M, Hsieh JC, Jessell TM, Edlund T.

Journal of leukocyte biology