Recombinant Human IL-1 beta/IL-1F2 Protein 201-LB-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-1 beta/IL-1F2 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $303.00Supplier Page View Company Product Page
Catalog Number201-LB-005
SpeciesHuman
Size5 ug (also 10 ug, 25 ug, 100 ug)
Molecule NameIL-1 beta/IL-1F2
NCBI Full Gene Nameinterleukin 1 beta
NCBI Gene AliasesIL1F2, IL1-BETA, IL-1, IL1beta
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 17 kDa, reducing conditions
Theoretical: 17 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human IL-1 beta/IL-1F2 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Development of autologous in vitro vascular models for use in preclinical biotherapeutic developmentBlood Vessels, Thrombosis & HemostasisMay 1, 2026Emma Lund, Alexander Silvester, Daniel Thwaites, Yasmin Bennour, Matthew McKechnie, Ross Beaumont, James Munday, Christopher Cooperno. 317347, BioLegend) and ANC28 (catalog no. 217669, EMD Millipore); 100 ng/mL IL-1β (catalog no. 201-LB-005, Bio-Techne) and TNFα (catalog no. 210-TA-005, Bio-Techne) or 10% heat-inactivated human AB serum and

(2) Messenger RNA delivery to islet β cells using conjugated lipid nanoparticlesCell Reports MedicineMarch 17, 2026Jacob R. Enriquez, Zhengjie Zhou, Jennifer B. Nelson, Fei Huang, Kayla T. Figatner, Advaita Chakraborty, Sarida Pratuangtham, Brian Xi, Sarah C. May, Matthew V. Tirrell, et al.containing 1000 IU/mL human IFN-γ (R&D Systems; 285-IF-100) and 50 IU/mL human IL-1β (R&D Systems; 201-LB-005). Cell lines and primary cultures MIN6 mouse β cells65 were cultured in high glucose (25mM) Dulbecco’s

(3) Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progressionJournal of Orthopaedic TranslationJanuary 13, 2026Xiuqin Peng, Jiaming Han, Yu Tian, Xiaohong Li, Xuanqi Zhang, Song Li, Jun Yang, Liang Chen, Siru Zhou, Nan Su, et al.(I3146, Sigma-Aldrich). Explants were then treated for 4 days with 10 ng/ml interleukin-1β (IL-1β) (201-LB-005, R&D Systems) and 100 ng/ml FGF8b (100-25, PeproTech) in this serum-free medium. 2.7 Chondrocyte culture SW1353

(4) NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repressioniScienceNovember 25, 2025Mahmoud M. Mostafa, Amandah Necker-Brown, Alex Gao, Andrew J. Thorne, Akanksha Bansal, Lucy Swift, Annika M. Maj, Sarah K. Sasse, Pina Colarusso, Anthony N. Gerber, et al.serum,Invitrogen,A3160702 HBSS,Invitrogen,14175079 PBS,Invitrogen,14190250 L-Glutamine,Invitrogen,25030081 G418,Sigma-Aldrich,A1720 Budesonide,AstraZeneca,gift Recombinant human IL-1b,R&D systems,201-LB-005 Actinomycin D,Sigma-Aldrich,A410 Quant-iT PicoGreen dsDNA Reagent,Invitrogen,P7581 "16% Paraformaldehyde

(5) Intra-Articular Delivery of Nanoemulsified Curcumin Ameliorates Joint Degeneration in a Chemically Induced Model of OsteoarthritisInternational Journal of Molecular SciencesNovember 20, 2025Kota Sri Naga Hridayanka, Shibsekhar Roy, Saikanth Varma, Navya Sree Boga, Archana Molangiri, Pradeep B. Patil, Myadara Srinivas, Asim K. Duttaroy, Sanjay Basak(#TIB-71) were obtained from the American Type Culture Collection (ATCC), (Manassas, VA, USA). IL1β (#201-LB-005) was procured from R&D Systems (Minneapolis, MN, USA). Fetal Bovine Serum (FBS) (#10270106), Trypsin-EDTA

(6) A TOM1 variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunityDisease models & mechanismsSeptember 1, 2025Lång HKM, Roach TG, Hölttä M, Keskitalo S, Varjosalo M, Heiskanen K, Collins MV, Seppänen MRJ, Capelluto DGS, Ikonen E, et al.

(7) Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cellsNature communicationsAugust 27, 2025Kowar A, Becker JP, Del Pizzo R, Tang Z, Champagne J, Wellach K, Samimi K, Galindo-Albarrán A, Körner PR, Montenegro Navarro J, et al.

(8) Fucoidan Modulates Osteoarthritis Progression Through miR-22/HO-1 PathwayCellsAugust 6, 2025Hsieh TH, Ho JY, Wang CC, Liu FC, Lee CH, Lee HS, Peng YJ.

(9) SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial HypertensionResearchSquareJuly 29, 2025Wei Sun, Ting Wu, Zijing Zhou, Danli Jiang, Tong-You Wei, So Yun Han, John Shyy, Gang Li, Ruizheng ShiCells at passages 3 to 15 were used for experiments. PAECs were treated with interleukin-1β (IL-1β) (201-LB-005, R&D Systems) at 10 ng/mL for 24 h. For viral infection, PAECs at 60% confluence were transduced with

(10) Genetic ancestry shapes dengue virus infection in human skin explantsProceedings of the National Academy of Sciences of the United States of AmericaJuly 15, 2025Castanha PMS, Martí MM, Duangkhae P, Taddonio JM, Cooper KL, Wallace M, Kettenburg G, Erdos G, Chavva H, Alex A, et al.

(11) Interactive Effects of IL-1β and TGF-β on Urokinase-Type Plasminogen Activator and α-Smooth Muscle Actin Expression by Corneal FibroblastsInvestigative ophthalmology & visual scienceJuly 1, 2025Sugioka K, Nishida T, Yunoki M, Mukai N, Murakami J, Kusaka S.

(12) Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in miceEBioMedicineJuly 1, 2025Syed F, Ballew O, Lee CC, Rana J, Krishnan P, Castela A, Weaver SA, Chalasani NS, Thomaidou SF, Demine S, et al.combination: IFNα (2000 U/mL, PeproTech, catalogue #300-02AA-1MG), IL-1β (50 U/mL, R&D Systems, catalogue #201-LB-005), and TNFα (1000 U/mL, PeproTech, catalogue #300-01A-50UG). Cytokine dosing and experimental endpoints

(13) Costunolide normalizes neuroinflammation and improves neurogenesis deficits in a mouse model of depression through inhibiting microglial Akt/mTOR/NF-κB pathwayActa pharmacologica SinicaJuly 1, 2025Zhang SQ, Deng Q, Tian C, Zhao HH, Yang LY, Cheng XW, Wang GP, Liu D.

(14) Ablation of VEGFA following a lumbar intervertebral disc injury attenuates intradiscal neurovascular features and prevents chronic low back pain symptomsbioRxiv : the preprint server for biologyJune 7, 2025Potter RS, Moon HJ, Clayton SW, Walk RE, Liefer AL, Jing L, Stratman AN, Setton LA, Gupta MC, Tang SY.

(15) A Study on the Levels of Selected Proangiogenic Proteins in Human Tissues and Plasma in Relation to Brain GliomaInternational journal of molecular sciencesMay 16, 2025Zielinska Z, Giełażyn J, Dzieciol-Anikiej Z, Dzieciol J, Mrozek P, Reszec-Gielazyn J, Gorodkiewicz E.

(16) Development of an Ophthalmic Hydrogel to Deliver MG53 and Promote Corneal Wound HealingPharmaceuticsApril 16, 2025Chandler HL, Moradi S, Green SW, Chen P, Madden C, Zhang L, Zhang Z, Park KH, Ma J, Zhu H, et al.

(17) Fibromodulin selectively accelerates myofibroblast apoptosis in cutaneous wounds by enhancing interleukin 1β signalingNature communicationsApril 12, 2025Jiang W, Pang X, Ha P, Li C, Chang GX, Zhang Y, Bossong LA, Ting K, Soo C, Zheng Z.

(18) Role of SerpinA3 in the Pathogenesis of Graves' Orbitopathy in Orbital FibroblastsInvestigative ophthalmology & visual scienceApril 1, 2025Kim MS, Choi SH, Park HY, Jang SY, Ko J, Kim JW, Yoon JS.

(19) Different IL-1β levels differentially mediate neuroprotection or neurodegeneration and may be related to BDNFCytokineApril 1, 2025Long S, Wang Y, Cheng R, Deng L, Chen L, Dong Y.

(20) Impact of a Heterozygous C1R(R301P/WT) Mutation on Collagen Metabolism and Inflammatory Response in Human Gingival FibroblastsCellsMarch 22, 2025Qu C, Koskinen Holm C.

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10/31/2019R&D Systems 201-LB Is Bound by R&D Systems Antibody MAB201 Anonymous ReviewerRecombinant Human IL-1 beta (201-LB, R&D Systems) is useful in binding assays and can likely be used in cellular assays as well.

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

Recombinant Human IL-1 beta/IL-1F2 Protein from R&D Systems, a Bio-Techne Brand

Description

R&D Systems, a Bio-Techne Brand

Citations (696)

Reviews

Recombinant Human IL-1 beta/IL-1F2 Protein from R&D Systems, a Bio-Techne Brand

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