Recombinant Mouse Netrin-1 Protein 1109-N1-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse Netrin-1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $449.00Supplier Page View Company Product Page
Catalog Number1109-N1-025
SpeciesMouse
Molecule NameNetrin-1
Size25 ug
FormatLyophilized from a 0.2 µm filtered solution in HEPES and NaCl with BSA as a carrier protein
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 83 kDa, reducing conditions
Theoretical: 68.2 kDa
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse Netrin-1 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Namenetrin 1
NCBI Gene AliasesNetrin-1

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in MiceAdvanced ScienceFebruary 1, 2026Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiongtreatments, cells were switched to serum‐free DMEM for 12 h. Treatments included Netrin‐1 (R&D System, 1109‐N1‐025) and KN93 (MCE, HY‐15465). No TGF‐β was added prior to the experimental treatments. 4.8 Calcium Imaging The

(2) Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson's diseaseJournal of advanced researchSeptember 4, 2025Han W, Wang T, Tan N, Liu H, He P, Hua Y, Fan Y.

(3) Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1bioRxiv : the preprint server for biologyJuly 26, 2025Ochiai Y, Kobayashi H, Sunagawa M, Baba T, Malagola E, Wu F, Tanaka T, Hata M, Arai J, Jiang Z, et al.

(4) Both GEF domains of the autism and developmental epileptic encephalopathy-associated Trio protein are required for proper tangential migration of GABAergic interneuronsMolecular psychiatryApril 1, 2025Eid L, Lokmane L, Raju PK, Tene Tadoum SB, Jiang X, Toulouse K, Lupien-Meilleur A, Charron-Ligez F, Toumi A, Backer S, et al.

(5) The regulatory role of the Netrin-1/UNC5H3 pathway in neuronal pyroptosis after strokeInternational immunopharmacologyJanuary 27, 2025Zhai Z, Huang Z, Huang K, Zhong Y, You H, Tao E, Yang Y.

(6) A human DCC variant causing mirror movement disorder reveals that the WAVE regulatory complex mediates axon guidance by netrin-1–DCCScience SignalingOctober 1, 2024Karina Chaudhari, Kaiyue Zhang, Patricia T. Yam, Yixin Zang, Daniel A. Kramer, Sarah Gagnon, Sabrina Schlienger, Sara Calabretta, Jean-Francois Michaud, Meagan Collins, et al.assay Dissociated commissural neurons were stimulated with 0.1 μg/ml BSA or Netrin-1 (R&D Systems, # 1109-N1–025) for 5 or 30 min and fixed with 4% PFA in PBS. The samples were then blocked with 5% BSA (IgG free)

(7) Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signalingCell reportsNovember 28, 2023Dudgeon C, Casabianca A, Harris C, Ogier C, Bellina M, Fiore S, Bernet A, Ducarouge B, Goldschneider D, Su X, et al.chamber containing either SSM, SSM+ 150 ng/mL recombinant human Netrin-1 in PBS/0.2% BSA (R&D Systems, 1109-N1-025), or medium +10% FBS. For invasion assays, transwells were coated with 1 mg/mL growth factor reduced

(8) Netrin1 patterns the dorsal spinal cord through modulation of Bmp signalingbioRxiv : the preprint server for biologyNovember 4, 2023Alvarez S, Gupta S, Honeychurch K, Mercado-Ayon Y, Kawaguchi R, Butler SJ.

(9) Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor controlScience advancesMay 12, 2023Schlienger S, Yam PT, Balekoglu N, Ducuing H, Michaud JF, Makihara S, Kramer DK, Chen B, Fasano A, Berardelli A, et al.gnomAD and shared by the seven affected individuals. Reagents Netrin-1 was purchased from R&D Systems (1109-N1-025, Minneapolis, MN) and BSA from MultiCell (500-0206). They were used at 100 ng/ml. Unless specified,

(10) Netrin-1 Promotes the Immunosuppressive Activity of MDSCs in Colorectal CancerCancer immunology researchMay 3, 2023Xia X, Mao Z, Wang W, Ma J, Tian J, Wang S, Yin K.

(11) Dephosphorylation of neural wiring protein shootin1 by PP1 phosphatase regulates netrin-1-induced axon guidanceThe Journal of biological chemistryMay 1, 2023Kastian RF, Baba K, Kaewkascholkul N, Sasaki H, Watanabe R, Toriyama M, Inagaki N.cell culture area, flows of culture medium with or without 300 ng/ml netrin-1 (R&D Systems, catalog number: 1109-N1-025) were applied to the microchannels on either side of the cell culture area for 420 min. For analysis

(12) Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage ResponseNature communicationsApril 10, 2023Ramalingam P, Gutkin MC, Poulos MG, Tillery T, Doughty C, Winiarski A, Freire AG, Rafii S, Redmond D, Butler JM.

(13) Tace/ADAM17 is a bi-directional regulator of axon guidance that coordinates distinct Frazzled and Dcc receptor signaling outputsCell reportsDecember 6, 2022Zang Y, Chaudhari K, Bashaw GJ.Triton X-100,Sigma-Aldrich,Cat#T8787–100ML TSA fluorescein system,AKOYA,Cat#NEL701A001KT Recombinant Mouse Netrin-1 Protein,R & D systems,Cat#1109-N1–025 Schneider’s Drosophila Medium,Life Technologies,Cat#21720024 Surfact-AMPS NP40,ThermoFisher,Cat#85124 Sodium orthovanadate

(14) Allosteric potentiation of GABA(A) receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasisCell reportsNovember 1, 2022Chan ES, Ge Y, So YW, Bai YF, Liu L, Wang YT.

(15) Spinal TRPA1 Contributes to the Mechanical Hypersensitivity Effect Induced by Netrin-1International journal of molecular sciencesJune 14, 2022Wei H, Ailanen L, Morales M, Koivisto A, Pertovaara A.

(16) The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult miceStem cell researchApril 1, 2022Barroca V, Racine C, Pays L, Fouchet P, Coureuil M, Allemand I.

(17) Endothelial Unc5B controls blood-brain barrier integrityNature communicationsMarch 4, 2022Boyé K, Geraldo LH, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, Nelson B, Xu Y, Jacob L, Maissa N, et al.

(18) A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosisNature communicationsAugust 11, 2021Pradella D, Deflorian G, Pezzotta A, Di Matteo A, Belloni E, Campolungo D, Paradisi A, Bugatti M, Vermi W, Campioni M, et al.

(19) Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologiesScience advancesApril 1, 2021Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z, Ye K.

(20) Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptorsCellular and molecular life sciences : CMLSMarch 1, 2021Hernaiz-Llorens M, Roselló-Busquets C, Durisic N, Filip A, Ulloa F, Martínez-Mármol R, Soriano E.Sigma-Aldrich), DMSO (D5879; Sigma-Aldrich), DAPI (D9542; Sigma-Aldrich), recombinant mouse Netrin-1 (1109-N1-025; R&D Systems, Inc), rat tail collagen type I (354236; BD Biosciences), cholesterol oxidase Streptomyces

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Recombinant Mouse Netrin-1 Protein

Netrin-1 Protein

Recombinant Mouse Netrin-1 Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse Netrin-1 Protein from R&D Systems, a Bio-Techne Brand

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