Recombinant Mouse gp130 Fc Chimera Protein, CF 468-MG-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse gp130 Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $454.00Supplier Page View Company Product Page
Catalog Number468-MG-100
SpeciesMouse
Molecule Namegp130
Size100 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
NCBI Full Gene Nameinterleukin 6 signal transducer
NCBI Gene Aliasesgp130, 5133400A03Rik, CD130, D13Ertd699e
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 115 kDa, reducing conditions
Theoretical: 94 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse gp130 Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Meningeal lymphatics-microglia axis regulates synaptic physiologyCellMay 15, 2025Kyungdeok Kim, Daviti Abramishvili, Siling Du, Zachary Papadopoulos, Jay Cao, Jasmin Herz, Igor Smirnov, Jean-Leon Thomas, Marco Colonna, Jonathan Kipnisaccording to the manufacturer’s instructions. Recombinant mouse gp130 Fc chimera protein (R&D systems, 468-MG-100) was dissolved at 45 ng/μL, ovalbumin (Hooke Laboratories Inc, DS0142) was dissolved at 4 ng/μL and

(2) Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritisCell Reports MedicineOctober 17, 2023Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, et al.SRP3083 Recombinant human gp130Fc,R&D Systems,Cat# 671-GP-100 Recombinant mouse gp130Fc,R&D Systems,Cat# 468-MG-100 Recombinant mouse hyper IL6,R&D Systems,Cat# 9038-SR-025 Penicillin-streptomycin,Hyclone,Cat# SV30010 Complete

(3) Administration of soluble gp130Fc disrupts M-1 macrophage polarization, dendritic cell activation, MDSC expansion and Th-17 induction during experimental cerebral malariaInternational immunopharmacologyOctober 1, 2023Mukherjee S, Ghosh S, Bawali S, Chatterjee R, Saha A, Sengupta A, Keswani T, Sarkar S, Ghosh P, Chakraborty S, et al.

(4) The fetal response to maternal inflammation is dependent upon maternal IL-6 in a murine modelCytokineJuly 1, 2023Bermick J, Watson S, Lueschow S, McElroy SJ.

(5) Modulation of interleukin-6 and its effect on late vein wall injury in a stasis mouse model of deep vein thrombosisJVS- vascular scienceJanuary 1, 2022Dowling AR, Luke CE, Cai Q, Pellerito AM, Obi AT, Henke PK.15).29, 30, 31, 32, 33, 34, 35 Soluble gp130 (recombinant mouse gp130 Fc chimera protein; catalog no. 468-mg-100; R&D Systems, Inc, Minneapolis, MN) was given by intraperitoneal injection at the dose of 2 μg/mouse

(6) Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathwayJournal of neuroinflammationJanuary 6, 2021Yoshizaki S, Tamaru T, Hara M, Kijima K, Tanaka M, Konno DJ, Matsumoto Y, Nakashima Y, Okada S.

(7) Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling InhibitionInvestigative ophthalmology & visual scienceSeptember 1, 2020Robinson R, Youngblood H, Iyer H, Bloom J, Lee TJ, Chang L, Lukowski Z, Zhi W, Sharma A, Sharma S.

(8) Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathyRedox biologyJuly 1, 2020Robinson R, Srinivasan M, Shanmugam A, Ward A, Ganapathy V, Bloom J, Sharma A, Sharma S.

(9) Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophagesArthritis research & therapyFebruary 12, 2020Trimova G, Yamagata K, Iwata S, Hirata S, Zhang T, Uemura F, Satoh M, Biln N, Nakayamada S, Maksymowych WP, et al.

(10) Frontline Science: Proliferation of Ly6C⁺ monocytes during urinary tract infections is regulated by IL-6 trans-signalingJournal of leukocyte biologyJanuary 1, 2018Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker HW, Squire A, et al.

(11) Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor ProgressionCancer researchMay 1, 2017Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, Fukuma D, Araki K, Mizuta H, Nakayama H, et al.

(12) Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-E-deficient mice is amenable to statin treatment and IL-6 inhibitionDisease Models & MechanismsSeptember 1, 2015Henrike Janssen et al.Heidelberg, Germany) or the fusion protein gp130-Fc (n=8; 200 µg subcutaneously, R&D systems, Art-no 468-MG-100, Minneapolis, USA) by a single subcutaneous injection after the double hit had been inflicted. Animals

(13) Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitisPloS oneJanuary 1, 2012Lee MJ, Lee JK, Choi JW, Lee CS, Sim JH, Cho CH, Lee KH, Cho IH, Chung MH, Kim HR, et al.

(14) Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cellsJournal of immunology (Baltimore, Md. : 1950)February 15, 2010Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, et al.

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gp130 Fc Chimera Protein

gp130 Fc Chimera Protein

Recombinant Mouse gp130 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse gp130 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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