Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF 551-MR-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse IL-15R alpha Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $454.00Supplier Page View Company Product Page
Catalog Number551-MR-100
SpeciesMouse
Size100 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
Molecule NameIL-15R alpha
NCBI Full Gene Nameinterleukin 15 receptor, alpha chain
NCBI Gene AliasesIL-15RA
Purity>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 80-90 kDa, 42 kDa and 35 kDa, reducing conditions
Theoretical: 44.9 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6Cell death & diseaseFebruary 7, 2025Woelk J, Hornsteiner F, Aschauer-Wallner S, Stoitzner P, Baier G, Hermann-Kleiter N.µg recombinant mIL-15 (BioLegend, 566302) and 1,63 µg recombinant mouse IL-15R alpha (R&D Systems, 551-MR-100) complexed for 30 minutes at 37°C) or PBS as described previously every third day and analyzed after

(2) CD94+ natural killer cells potentiate pulmonary ischaemia-reperfusion injuryEuropean Respiratory JournalSeptember 26, 2024Tasha Tsao, Longhui Qiu, Reena Bharti, Avishai Shemesh, Alberto M. Hernandez, Simon J. Cleary, Nancy Y. Greenland, Jesse Santos, Ruoshi Shi, Lu Bai, et al.recombinant IL-15 (R&D Systems, 447ML010CF) with 10.05 ug of mouse recombinant IL-15Rα-Fc (R&D Systems, 551MR100) and incubated at 37°C for 20 minutes. As a negative control, we also performed syngeneic orthotopic

(3) Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicityScience advancesDecember 1, 2023Kang S, Mansurov A, Kurtanich T, Chun HR, Slezak AJ, Volpatti LR, Chang K, Wang T, Alpar AT, Refvik KC, et al.

(4) CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injuryJCI insightNovember 8, 2023Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, et al.recombinant IL-15 (R&D Systems, 447ML010CF) with 10.05 μg of mouse recombinant IL-15Rα-Fc (R&D Systems, 551MR100) and incubated at 37°C for 20 minutes. Lungs were collected 3 days later for immunophenotyping. Acute lung injury

(5) Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15Cell reportsOctober 31, 2023Devarajan P, Vong AM, Castonguay CH, Silverstein NJ, Kugler-Umana O, Bautista BL, Kelly KA, Luban J, Swain SL.(ISQAVHAAHAEINEAGR),New England Peptide,N/A Recombinant Mouse IL-15R alpha Fc Chimera Protein,R&D Systems,551-MR-100 Recombinant Mouse IL-15,Tonbo Biosciences,21–8153-U500 Critical commercial assays,Critical commercial

(6) CD8+ Regulatory T Cells Induced by Lipopolysaccharide Improve Mouse Endotoxin ShockImmunoHorizonsMay 1, 2023Nanaka Morita, Masato Hoshi, Hiroyuki Tezuka, Tatsuya Ando, Sayaka Yoshida, Fumiaki Sato, Hiroyuki Yokoi, Hiroyasu Ito, Kuniaki Saitono. 566302). Mouse IL-15Rα subunit Fc chimera (IL-15 Rα) was purchased from R&D Systems (catalog no. 551-MR-100; Minneapolis, MN). Recent work has shown that the effects of IL-15 can be markedly enhanced by combining

(7) Tyrosine Kinase Inhibition Alters Intratumoral CD8+ T-cell Subtype Composition and ActivityCancer immunology researchOctober 4, 2022Tieniber AD, Hanna AN, Medina BD, Vitiello GA, Etherington MS, Liu M, Do KJ, Rossi F, DeMatteo RP.

(8) Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cellsCellular & molecular immunologySeptember 1, 2021Yu M, Pan H, Che N, Li L, Wang C, Wang Y, Ma G, Qian M, Liu J, Zheng M, et al.

(9) Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signalsNature communicationsApril 1, 2021Tao H, Pan Y, Chu S, Li L, Xie J, Wang P, Zhang S, Reddy S, Sleasman JW, Zhong XP.

(10) Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow RecoveryMolecular therapy : the journal of the American Society of Gene TherapyOctober 7, 2020Sommer C, Cheng HY, Nguyen D, Dettling D, Yeung YA, Sutton J, Hamze M, Valton J, Smith J, Djuretic I, et al.

(11) The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammationNature immunologyOctober 1, 2020Ng SS, De Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, Kuns R, Chauhan SB, Hou J, Li XY, et al.

(12) Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cellsNature communicationsMay 4, 2020Lucas B, White AJ, Cosway EJ, Parnell SM, James KD, Jones ND, Ohigashi I, Takahama Y, Jenkinson WE, Anderson G.

(13) Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathwayJCI insightJune 18, 2019Alvarez M, Simonetta F, Baker J, Pierini A, Wenokur AS, Morrison AR, Murphy WJ, Negrin RS.

(14) NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial ImmunityJournal of immunology (Baltimore, Md. : 1950)March 15, 2019Simonović N, Witalisz-Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, Farlik M, Bock C, Sexl V, Müller M, et al.

(15) Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexationPloS oneJanuary 1, 2019Schmid AS, Neri D.(PeproTech, #200–15), a recombinant mouse IL15Rα(33–205)-Fc chimera (named muIL15RαFc) (R&D Systems, 551-MR-100), a recombinant human IL15Rα(1–205)-Fc chimera (named huIL15RαFc) (R&D Systems, 7194-IR-050) and an

(16) Frequencies of IL-15Rα+ cells in patients with Behçet's disease and the effects of overexpressing IL-15Rα+ on disease symptoms in miceCytokineOctober 1, 2018Islam SMS, Choi B, Choi J, Lee ES, Sohn S.

(17) Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer CellsImmunityApril 17, 2018Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, et al.

(18) Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1Journal of immunology (Baltimore, Md. : 1950)March 1, 2018DeLong JH, Hall AO, Konradt C, Coppock GM, Park J, Harms Pritchard G, Hunter CA.

(19) IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal TissuesJournal of immunology (Baltimore, Md. : 1950)October 1, 2017Sowell RT, Goldufsky JW, Rogozinska M, Quiles Z, Cao Y, Castillo EF, Finnegan A, Marzo AL.

(20) Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK CellsCancer immunology researchSeptember 1, 2017Kubo H, Mensurado S, Gonçalves-Sousa N, Serre K, Silva-Santos B.

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Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse IL-15R alpha Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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