Recombinant Human IL-12 Protein 219-IL-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-12 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $404.00Supplier Page View Company Product Page
Catalog Number219-IL-005
SpeciesHuman
Molecule NameIL-12
Size5 ug (also 25 ug)
NCBI Full Gene Nameinterleukin 12B, interleukin 12A
NCBI Gene AliasesCLMF, IL-12A, NFSK, NKSF, NKSF2, NKSF1, CLMF2, P35, IMD29, IMD28, IL-12B
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 41 kDa (p40) & 29 kDa (p35), reducing conditions
Theoretical: 34.7 kDa (p40) & 22.5 kDa (p35)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Human IL-12 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast CancerCancer immunology researchApril 2, 2025Schwarz E, Savardekar H, Zelinskas S, Mouse A, Lapurga G, Lyberger J, Rivaldi A, Ringwalt EM, Miller KE, Yu L, et al.(<0.01%) DMSO (Sigma-Aldrich Cat. #D2650-100ML), 10 ng/mL recombinant human IL-12 (R&D Systems Cat. #219-IL-005), and/or 2.5 nmol/L trabectedin (MedChemExpress Cat. #HY-50936). Flow cytometry Purity of isolated

(2) Gut-homing and intestinal TIGIT(neg)CD38(+) memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn's disease patients with a severe disease courseMucosal immunologyApril 1, 2025Heredia M, Barendregt DMH, Tindemans I, Klomberg RCW, Aardoom MA, Calado B, Costes LMM, Joosse ME, Hulleman-van Haaften DH, Tuk B, et al.

(3) Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell functionNature communicationsMarch 15, 2025Li Y, Ascui G, Dicker M, Riffelmacher T, Chandra V, Schmiedel B, Chou TF, Vijayanand P, Kronenberg M.

(4) Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokinesNature communicationsFebruary 26, 2025Parween F, Singh SP, Kathuria N, Zhang HH, Ashida S, Otaizo-Carrasquero FA, Shamsaddini A, Gardina PJ, Ganesan S, Kabat J, et al.anti-human CCR2 antibody was PE-conjugated (Cat# 357206, BioLegend), and cultured in IL-12 (20 ng/mL, Cat# 219-IL-005; R&D Systems), IL-18 (20 ng/mL Cat# 9124-IL-010; R&D Systems), IL-23 (20 ng/mL, Cat# 1290-IL-010/CF;

(5) CITE-Seq Analysis Reveals a Differential Natural Killer Cell SPON2 Expression in Cardiovascular Disease Patients Impacted by Human-Cytomegalovirus Serostatus and DiabetesInternational journal of molecular sciencesFebruary 6, 2025Armstrong SS, Chen DG, Kumar S, Heath JR, Feinstein MJ, Greenland JR, Calabrese DR, Lanier LL, Ley K, Shemesh A.

(6) Chronic stimulation desensitizes β2-adrenergic receptor responses in natural killer cellsEuropean journal of immunologyDecember 1, 2024Jürgens M, Claus M, Wingert S, Niemann JA, Picard LK, Hennes E, Haasler I, Hellwig B, Overbeck N, Reinders J, et al.

(7) hsa_circ_0007755 competitively adsorbs miR-27b-3p to mediate CXCL2 expression and recruit Th1 cells to promote hypertrophic scars developmentHeliyonNovember 15, 2024Qi J, Wu Y, Liu Y, Ma J, Wang Z.

(8) Interferon-mediated NK cell activation is associated with limited neutralization breadth during SARS-CoV-2 infectionbioRxiv : the preprint server for biologyOctober 22, 2024de Los Rios Kobara I, Jayewickreme R, Lee MJ, Wilk AJ, Stanford COVID-19 Biobank, Blomkalns AL, Nadeau KC, Yang S, Rogers AJ, Blish CA.

(9) Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the TumorAdvanced science (Weinheim, Baden-Wurttemberg, Germany)October 1, 2024Offeddu GS, Cambria E, Shelton SE, Haase K, Wan Z, Possenti L, Nguyen HT, Gillrie MR, Hickman D, Knutson CG, et al.across the MVNs before measurement of L p. Recombinant human IL8 (#208‐IL‐010, R&D Systems), IL12 (#219‐IL‐005, R&D Systems), TNFα (#210‐TA‐005, R&D Systems), CCL2 (#279‐MC‐010, R&D Systems), CCL4 (#271‐BME‐010,

(10) Tuberculosis in otherwise healthy adults with inherited TNF deficiencyNatureSeptember 1, 2024Arias AA, Neehus AL, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J, et al.

(11) SIRT3 Negatively Regulates TFH-Cell Differentiation in CancerCancer immunology researchJuly 2, 2024Hou Y, Cao Y, He Y, Dong L, Zhao L, Dong Y, Niu R, Bi Y, Liu G.

(12) Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor EffectsCancer immunology researchJune 4, 2024Menachem A, Alteber Z, Cojocaru G, Fridman Kfir T, Blat D, Leiderman O, Galperin M, Sever L, Cohen N, Cohen K, et al.

(13) FLT3L governs the development of partially overlapping hematopoietic lineages in humans and miceCellMay 23, 2024Momenilandi M, Lévy R, Sobrino S, Li J, Lagresle-Peyrou C, Esmaeilzadeh H, Fayand A, Le Floc'h C, Guérin A, Della Mina E, et al.anti-CD2/CD3/CD28, Miltenyi Biotec) + IL-2 (50 IU/mL, #IL002, Merck) alone (TH0) or under TH1 (IL-12 [50 ng/mL, # 219-IL-005, R&D Systems]), or TH17 (TGF-β1 [2.5 ng/mL, #100–21C-10, Peprotech], IL-1β [50 ng/mL,#200–01B-10, Peprotech],

(14) Cytokine Response of Natural Killer Cells to Hepatitis B Virus Infection Depends on Monocyte Co-StimulationVirusesMay 8, 2024Kupke P, Brucker J, Wettengel JM, Protzer U, Wenzel JJ, Schlitt HJ, Geissler EK, Werner JM.

(15) IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translationProceedings of the National Academy of Sciences of the United States of AmericaMarch 26, 2024Tilsed CM, Sadiq BA, Papp TE, Areesawangkit P, Kimura K, Noguera-Ortega E, Scholler J, Cerda N, Aghajanian H, Bot A, et al.

(16) The hTERT and iCasp9 Transgenes Affect EOMES and T-BET Levels in NK Cells and the Introduction of Both Genes Improves NK Cell Proliferation in Response to IL2 and IL15 StimulationBiomedicinesMarch 14, 2024Palamarchuk AI, Kovalenko EI, Streltsova MA.

(17) IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblastsJournal of hematology & oncologyFebruary 9, 2024Van den Eynde A, Gehrcken L, Verhezen T, Lau HW, Hermans C, Lambrechts H, Flieswasser T, Quatannens D, Roex G, Zwaenepoel K, et al.

(18) Impact of IL-21 on Natural Killer cell proliferation and function - a mathematical and functional assessmentbioRxiv : the preprint server for biologyJanuary 30, 2024Biondo R, Nayak I, Möker N, Zhang C, Stewart WC, Khakoo S, Das J.

(19) Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancyNature communicationsJanuary 15, 2024Ren J, Liao X, Lewis JM, Chang J, Qu R, Carlson KR, Foss F, Girardi M.

(20) TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier functionScientific reportsSeptember 2, 2023Twarog M, Schustak J, Xu Y, Coble M, Dolan K, Esterberg R, Huang Q, Saint-Geniez M, Bao Y.

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IL-12 Protein

IL-12 Protein

IL-12 Protein

IL-12 Protein

IL-12 Protein

Recombinant Human IL-12 Protein from R&D Systems, a Bio-Techne Brand

Description

R&D Systems, a Bio-Techne Brand

Citations (164)

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Recombinant Human IL-12 Protein from R&D Systems, a Bio-Techne Brand

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