Recombinant Human GDNF Protein 212-GD-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human GDNF Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $362.00Supplier Page View Company Product Page
Catalog Number212-GD-010
SpeciesHuman
Molecule NameGDNF
Size10 ug (also 50 ug, 1 mg)
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight11.6 kDa (monomer)
ApplicationsBioactivity, Binding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human GDNF Protein
NCBI Gene AliasesATF, HFB1-GDNF, ATF1, HSCR3, ATF2
NCBI Full Gene Nameglial cell derived neurotrophic factor
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectoriesCell Stem CellJanuary 8, 2026Madison R. Glass, Nana Matoba, Alvaro A. Beltran, Niyanta K. Patel, Tala M. Farah, Karthik Eswar, Shivam Bhargava, Karen Huang, Ian Curtin, Sara Ahmed, et al.Acid,Sigma-Aldrich,A4544 cyclic AMP,Sigma-Aldrich,A6885 BDNF,Life Technologies,PHC7074CS1 GDNF,R&D Systems,212-GD-010 96 well v-bottomed ultra-low attachment plate,S-Bio,MS-9096VZ Growth Factor Reduced Matrigel,Corning,356230 Papain

(2) Cecal growth factors promote enteric neurosphere formation and hindgut colonization in the avian modelFront Cell Dev BiolDecember 18, 2025Ádám Soós, Emőke Szőcs, Viktória Halasy, Zsanna Gecse, Fruzsina Mógor, Csenge Jurenka, Katalin Kocsis, Jitka Mucksová, Jiří Hejnar, Nándor Nagyfurther supplemented with 10 ng/mL glial cell line-derived neurotrophic factor (GDNF; R&D Systems, 212-GD-010), 200 ng/mL WNT11 (Origene, TP761904), 250 ng/mL endothelin-3 (ET-3; R&D Systems, 1,162/100U), and 100

(3) Protocol for 3D direct reprogramming of human glia into dopaminergic neurons with gene expression and immunocytochemistry validationSTAR ProtocolsDecember 1, 2025Jessica Giacomoni, Kerstin Laurin, Malin Parmar, Mette Habekost15140122 Poly-L-Ornithine,Sigma-Aldrich,Cat# P4957 Recombinant Human GDNF Protein,R&D Systems,Cat# 212-GD-010 Recombinant Human IGF-I Protein,R&D Systems,Cat# 291-G1-200 Recombinant Human Noggin Protein,Miltenyi Biotec

(4) In vitro derivation of midbrain dopaminergic neurons from porcine embryonic stem cells in multi-dimensional conditionsStem Cell Research & TherapyNovember 5, 2025Hyerin Choi, Dongjin Oh, Ali Jawad, Zheng Haomiao, Jaehyung Ham, Juyoung Heo, Aram Oh, Huijin Jin, Jaehyeok Seo, Byoung Chol Oh, et al.These cells were cultured in B27 medium supplemented with 20 ng/ml BDNF, 10 ng/ml GDNF (R&D Systems, #212-GD-010), 0.2 mM ascorbic acid, 0.5 mM db-cAMP (STEM CELL, #73886), and 10 µM DAPT (MCE, HY-13027), with medium

(5) Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomesmBioOctober 8, 2025Alyssa Richman, Sophie Kogut, Terri Edwards, Joseph Boyd, Princess Rodriguez, Michael Mariani, Mason A. Shipley, Kayley A. Manuel, Ziyun A. Ye, David C. Bloom, et al.Sigma), and a 2 ng/mL final concentration recombinant human glial cell-derived neurotrophic factor (no. 212-GD-010; R&D Systems) at 60%–70% confluence to induce differentiation as previously described (42). Original

(6) Lys-specific gingipain (Kgp) of P. gingivalis promotes viral infection by disabling the interferon pathwaymBioOctober 8, 2025Dobosz E, Golda A, Kanoza M, Kowalczuk W, Potempa B, Potempa J, Gasiorek A, Madeja N, Budziaszek J, Mizgalska D, et al.

(7) Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunctionbioRxiv : the preprint server for biologySeptember 2, 2025Guo C, Chen K, Vatsavayai SC, Akiyama T, Zeng Y, Liu C, Sianto O, Yang E, Bombosch J, Powell R, et al.

(8) Engineering kidney developmental trajectory using culture boundary conditionsNature communicationsAugust 22, 2025Huang AZ, Prahl LS, Xu K, Mauck RL, Burdick JA, Hughes AJ.

(9) A More Rapid Method for Culturing LUHMES-Derived Neurons Provides Greater Cell Numbers and Facilitates Studies of Multiple VirusesVirusesJuly 16, 2025Adam W. Whisnant, Stephanie E. Clark, José Alberto Aguilar-Briseño, Lorellin A. Durnell, Arnhild Grothey, Ann M. Miller, Steven M. Varga, Jeffery L. Meier, Charles Grose, Patrick L. Sinn, et al.(Sigma #D0627), and 2 ng/mL recombinant human Glial cell-derived neurotrophic factor (GDNF, R&D Systems #212-GD-010 Minneapolis, MN, USA). The differentiation medium could be kept several weeks at 4 °C. The culturing

(10) Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell linesCell stem cellJune 5, 2025Scuderi S, Kang TY, Jourdon A, Nelson A, Yang L, Wu F, Anderson GM, Mariani J, Tomasini L, Sarangi V, et al.

(11) Hypoxia Promotes the In Vitro Proliferation of Buffalo Spermatogonial Cells by Increasing Lactate and H3K18la Lactylation LevelsCellsJune 3, 2025Li M, Ma Y, Wang S, Zheng H, Yang C, Duan A, Zhou B, Shang J, Liang X, Yang X.

(12) Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALSNature communicationsMay 19, 2025Schweingruber C, Nijssen J, Mechtersheimer J, Reber S, Lebœuf M, O''Brien NL, Mei I, Hedges E, Keuper M, Benitez JA, et al.1141], 2.5 µM DAPT [Tocris, 2634], 10 ng/mL each of BDNF [R&D Systems, 248-BD-025], GDNF [R&D Systems, 212-GD-010], NT-3 [R&D Systems, 267-N3-025], and CNTF [R&D Systems, 257-NT-010]), and three days of medium d11–13

(13) ZSCAN21 mediates the pathogenic transcriptional induction of α-synuclein in cellular and animal models of Parkinson's diseaseCell death & diseaseMay 16, 2025Kozoriz A, Mora S, Damiano MA, Carballo-Carbajal I, Parent A, Kumarasinghe L, Vila M, Lassot I, Desagher S.

(14) C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7Acta neuropathologica communicationsMarch 26, 2025Wang KS, Smeyers J, Eggan K, Budnik B, Mordes DA.

(15) Oxidative Stress Suppresses Trk Signaling While Stimulating JNK ‐Mediated Endocytosis and Cleavage of p75 NTR : A Targetable Pathway for Neuroprotection in a Parkinson's Disease ModelJournal of NeurochemistryFebruary 1, 2025Poshan V. Pokharel, Aaron M. Newchurch, Sunny C. Overby, Cassidy A. Spease, Isaac T. Perkins, Lorelei G. Darzi, Nabin Ghimire, Ahmed Lawan, Bradley R. Kraemerng/mL glial cell line-derived neurotrophic factor (GDNF) (R&D Systems, Minneapolis, MN, USA, Cat no: 212-GD-010), and 1 μg/mL tetracycline (Sigma-Aldrich, St. Louis, MO, USA, no: 87128-25G). Cultures were maintained

(16) Role of immature choroid plexus in the pathology of model mice and human iPSC-derived organoids with autism spectrum disorderCell reportsJanuary 28, 2025Tanabe M, Saito Y, Takasaki A, Nakano K, Yamamoto S, Suzuki C, Kawamura N, Hattori A, Oikawa M, Nagashima S, et al.

(17) Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)Nature communicationsJanuary 3, 2025Larrea D, Tamucci KA, Kabra K, Velasco KR, Yun TD, Pera M, Montesinos J, Agrawal RR, Paradas C, Smerdon JW, et al.

(18) The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neuronsPloS oneJanuary 1, 2025Policarpo R, Wolfs L, Martínez-Montero S, Vandermeulen L, Royaux I, Van Peer G, Mestdagh P, De Strooper B, Sierksma A, d'Ydewalle C.

(19) Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brainNature biotechnologyJanuary 1, 2025Wang M, Zhang L, Novak SW, Yu J, Gallina IS, Xu LL, Lim CK, Fernandes S, Shokhirev MN, Williams AE, et al.

(20) Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neuronsMolecular neurodegenerationDecember 31, 2024Marvian AT, Strauss T, Tang Q, Tuck BJ, Keeling S, Rüdiger D, Mirzazadeh Dizaji N, Mohammad-Beigi H, Nuscher B, Chakraborty P, et al.

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GDNF Protein

GDNF Protein

GDNF Protein

GDNF Protein

GDNF Protein

Recombinant Human GDNF Protein from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Recombinant Human GDNF Protein from R&D Systems, a Bio-Techne Brand

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