Sonic Hedgehog/Shh N-Terminus Protein 1314-SH-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemSonic Hedgehog/Shh N-Terminus Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $292.00Supplier Page View Company Product Page
Catalog Number1314-SH-025
SpeciesHuman
Molecule NameSonic Hedgehog/Shh
Size25 ug
NCBI Full Gene Namesonic hedgehog signaling molecule
NCBI Gene AliasesHPE3, SMMCI, HHG1, TPT, HLP3, TPTPS, ShhNC, MCOPCB5
FormatLyophilized from a 0.2 µm filtered solution in NaH2PO4, NaCl and DTT with BSA as a carrier protein
Purity>97%, by SDS-PAGE with silver staining, under reducing conditions
Molecular WeightObserved: 22 kDa, reducing conditions
Theoretical: 20 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human Sonic Hedgehog/Shh, N-Terminus Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitorsDevelopmental CellFebruary 5, 2024Yuji Atsuta, ChangHee Lee, Alan R. Rodrigues, Charlotte Colle, Reiko R. Tomizawa, Ernesto G. Lujan, Patrick Tschopp, Laura Galan, Meng Zhu, Joshua M. Gorham, et al.Alcian Blue 8GX,Sigma,A3157–25G Polybrene,Sigma-Aldrich,H9268–10G "Glass Bottom Multi-well Plate, 24-well",MatTek orporation,P24G-0-13-F Shh-N,R&D systems,1314-SH-025 Doxycycline,Sigma-Aldrich,D3447–500MG Critical Commercial Assays,Critical Commercial Assays,Critical

(2) Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cellsNature communicationsDecember 5, 2023Maimaitili M, Chen M, Febbraro F, Ucuncu E, Kelly R, Niclis JC, Christiansen JR, Mermet-Joret N, Niculescu D, Lauritsen J, et al.

(3) Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell developmentScientific reportsJuly 29, 2023Lee J, Kim Y, Ataliotis P, Kim HG, Kim DW, Bennett DC, Brown NA, Layman LC, Kim SH.

(4) SLITRK5 is a negative regulator of hedgehog signaling in osteoblastsNature communicationsJuly 29, 2021Sun J, Shin DY, Eiseman M, Yallowitz AR, Li N, Lalani S, Li Z, Cung M, Bok S, Debnath S, et al.plates. The plates were incubated at room temperature for 2 h before being washed four times. SHH-His (1314-SH-025, R&D systems) or control His peptide was added and the plates were incubated for another 2 h at room

(5) Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migrationNature communicationsApril 24, 2020Kim Y, Lee J, Seppala M, Cobourne MT, Kim SH.

(6) Sonic Hedgehog repression underlies gigaxonin mutation-induced motor deficits in giant axonal neuropathyThe Journal of clinical investigationDecember 2, 2019Arribat Y, Mysiak KS, Lescouzères L, Boizot A, Ruiz M, Rossel M, Bomont P.

(7) Gelatin Endorses the Pluripotent Stem Cells from the Reprogrammed Fibroblasts of Adult Mice Differentiation into Subtypes of Neurons in the Feeder-Free Condition for a Long-TermJournal of Stem Cell Research & TherapyJanuary 1, 2018Gele Liuconsisted of FGF-8b (100 ng/mL, Invitrogen PHG0271) and sonic hedgehog (200 ng/mL, SHH, R&D systems 1314-SH-025), being liquefied into the Neurobasal® medium with other nutrition contents - heparin solution, N-2

(8) Ex vivo analysis of the contribution of FGF10⁺ cells to airway smooth muscle cell formation during early lung developmentDevelopmental dynamics : an official publication of the American Association of AnatomistsJuly 1, 2017El Agha E, Kheirollahi V, Moiseenko A, Seeger W, Bellusci S.

(9) Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem CellsStem cells internationalJanuary 1, 2017Johansen T, Krabbe C, Schmidt SI, Serrano AM, Meyer M.

(10) Nonviral Reprogramming Genes Accelerate Formation of Neurons from Murine Embryonic Brain Cells: Synergistic Effect of Brain Derived Neurotrophic Factor Gene TherapyTranslational MedicineJanuary 1, 2016Liu Gincorporating 100 ng/mL FGF-8b (Invitrogen, PHG0271) and 200 ng/mL sonic hedgehog (SHH, R&D systems 1314-SH-025), as well as Neurobasal® medium, heparin solution, N-2 supplement without vitamin A (Invitrogen, 12587-010), and

(11) In vitro generation of human pluripotent stem cell derived lung organoidseLifeMarch 24, 2015Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, et al.

(12) Nonviral Reprogramming Genes Accelerate Formation of Neurons from Murine Embryonic Brain Cells: Synergistic Effect of Brain Derived Neurotrophic Factor Gene TherapyJournal of Cell Science & TherapyJanuary 1, 2015Liu Gincorporating 100 ng/mL FGF-8b (Invitrogen, PHG0271) and 200 ng/mL sonic hedgehog (SHH, R&D systems 1314-SH-025), as well as Neurobasal® medium, heparin solution, Reprogramming genes and neurotrophic factors fuel

(13) Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cellsOncology reportsFebruary 1, 2014Xu Y, An Y, Wang X, Zha W, Li X.

(14) Use of induced pluripotent stem cell derived neurons engineered to express BDNF for modulation of stressor related pathologyFrontiers in cellular neuroscienceJanuary 1, 2014Liu G, Rustom N, Litteljohn D, Bobyn J, Rudyk C, Anisman H, Hayley S.Medium, containing 100 ng/mL FGF-8b (Invtrogen PHG0271) and 200 ng/mL sonic hedgehog (SHH, R&D systems 1314-SH-025), as well as Neurobasal®; medium, heparin solution, N-2 supplement without vitamin A (Invtrogen 12587-010),

(15) Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformationThe Journal of biological chemistryApril 26, 2013Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME.

(16) The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systemsBiology of reproductionOctober 1, 2012Aad PY, Echternkamp SE, Sypherd DD, Schreiber NB, Spicer LJ.

(17) Plasma Shh levels reduced in pancreatic cancer patientsPancreasOctober 1, 2012El-Zaatari M, Daignault S, Tessier A, Kelsey G, Travnikar LA, Cantu EF, Lee J, Plonka CM, Simeone DM, Anderson MA, et al.

(18) Derivation of cerebellar neurons from human pluripotent stem cellsCurrent protocols in stem cell biologyMarch 1, 2012Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya SS.

(19) Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cellsFEBS lettersFebruary 4, 2009Gil JE, Woo DH, Shim JH, Kim SE, You HJ, Park SH, Paek SH, Kim SK, Kim JH.

(20) Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stageGenes & developmentJanuary 15, 2008Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L.

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Sonic Hedgehog/Shh N-Terminus Protein

Sonic Hedgehog/Shh N-Terminus Protein

Sonic Hedgehog/Shh N-Terminus Protein

Sonic Hedgehog/Shh N-Terminus Protein

Sonic Hedgehog/Shh N-Terminus Protein

Sonic Hedgehog/Shh N-Terminus Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Sonic Hedgehog/Shh N-Terminus Protein from R&D Systems, a Bio-Techne Brand

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