Recombinant Human Cathepsin L Protein, CF 952-CY-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Cathepsin L Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $454.00Supplier Page View Company Product Page
Catalog Number952-CY-010
SpeciesHuman
Molecule NameCathepsin L
Size10 ug
FormatSupplied as a 0.2 µm filtered solution in Sodium Acetate and NaCl
NCBI Full Gene Namecathepsin L
NCBI Gene AliasesCTSL1, CATL, MEP
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 36 kDa, reducing conditions
Theoretical: 26 kDa
ApplicationsEnzyme Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Cathepsin L Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Discovery of benzyl carbamate inhibitors of coronavirus M pro enzymes from a legacy collection of cysteine protease inhibitorsJournal of Enzyme Inhibition and Medicinal ChemistryDecember 31, 2025Mateus Sá Magalhães Serafim, Thales Kronenberger, Karol R. Francisco, Erik Vinicius de Sousa Reis, Ellen Gonçalves de Oliveira, Fernanda Kelly Marcelino e Oliveira, Isadora Serraglio Fortes, Thaís Helena Maciel Fernandes, Elany Barbosa da Silva, Pavla Fajtova, et al.PLpro was purchased from Acro Biosystems (PAE-C5184). Recombinant hCatL was purchased from R&D Systems (952-CY-010). SARS-CoV-2, SARS-CoV, and MERS-CoV Mpro inhibition assays The inhibitor collection was screened

(2) Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral ActivityJournal of Medicinal ChemistrySeptember 25, 2025Philipp Flury, Jyoti Vishwakarma, Katharina Sylvester, Nobuyo Higashi-Kuwata, Agnieszka K. Dabrowska, Renee Delgado, Ashley Cuell, Rahul Basu, Alexander B. Taylor, Ellen Gonçalves de Oliveira, et al.MERS-CoV Mpro were preincubated at 20 μM for 15 min with 160 pM of recombinant enzyme (R&D Systems, 952-CY-010) in an assay buffer consisting of 40 mM sodium acetate at pH 5.5, 100 mM NaCl, 5 mM DTT, 1 mM EDTA,

(3) Host cell and viral protease targets of human SERPINs identified by in silico dockingThe EMBO JournalSeptember 8, 2025Joaquin Rodriguez Galvan, Maren de Vries, Shiraz Belblidia, Ashley Fisher, Rachel A Prescott, Keaton M Crosse, Patrick Hearing, Walter F Mangel, Ralf Duerr, Meike Dittmannantibody depletion experiments. rTMPRSS2 was obtained from Biomatik (RPC24995), rCTSL from R&D Systems (952-CY-010), rCTSB from R&D Systems (953-CY-010) and recombinant active urokinase plasminogen activator from Abcam.

(4) The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolutionPLoS biologyAugust 1, 2024Chazot A, Zimberger C, Feracci M, Moussa A, Good S, Sommadossi JP, Alvarez K, Ferron F, Canard B.

(5) Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cellsFrontiers in pharmacologyJanuary 1, 2024Sutton VR, Watt SV, Akhlaghi H, Cipolla DC, Chen KJ, LaSala D, McDonald PP, Beavis PA, Munoz I, Hodel AW, et al.

(6) Rational design of humanized antibody inhibitors for cathepsin SArchives of Biochemistry and BiophysicsJanuary 1, 2024Po-Wen Yu, Guoyun Kao, Zhefu Dai, Fariborz Nasertorabi, Yong Zhangpurchased from New England Biolabs (Ipswich, MA). Recombinant human CTSS (1183-CY-010), human CTSL (952-CY-010), human CTSB (953-CY-010), and fluorogenic peptide substrate Z-FR-AMC (ES009) were purchased from R&D Systems

(7) Cathepsin V regulates cell cycle progression and histone stability in the nucleus of breast cancer cellsFrontiers in PharmacologyNovember 6, 2023Naphannop Sereesongsaeng, James F. Burrows, Christopher J. Scott, Klaudia Brix, Roberta E. Burdenusing GraphPad Prism 8. In vitro cleavage assay Recombinant CTSV (1080-CY-010, BioTechne) and CTSL (952-CY-010, BioTechne) were activated before analysis according to manufacturer’s instructions. Activated CTSV

(8) Regulation of extracellular progranulin in medial prefrontal cortexNeurobiology of DiseaseNovember 1, 2023Azariah K. Kaplelach, Stephanie N. Fox, Anna K. Cook, Justin A. Hall, Ryan S. Dannemiller, Karen L. Jaunarajs, Andrew E. Arrant#AG-40A-0189Y) was cleaved overnight at 37 °C with 6 ng of recombinant human cathepsin L (R&D systems #952-CY-010) using a previously described protocol (Lee et al., 2017). For control samples, progranulin was incubated

(9) Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3Nature communicationsOctober 5, 2023Heggelund JE, Das S, Stamnaes J, Iversen R, Sollid LM.

(10) Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH RangeBiochemistryAugust 1, 2023Yoon MC, Phan V, Podvin S, Mosier C, O'Donoghue AJ, Hook V.obtained for this study were procathepsin B (R&D Systems, #953-CY-010), active cathepsin L (R&D Systems, #952-CY-010), active cathepsin K (Abcam, #ab157067), procathepsin S (R&D Systems, #1183-CY-010), procathepsin V

(11) mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor ImmunityCancer immunology researchJuly 5, 2023Nirschl CJ, Brodkin HR, Domonkos C, Dwyer CJ, Hicklin DJ, Ismail N, Seidel-Dugan C, Steiner P, Steuert Z, Sullivan JM, et al.

(12) Hederacolchiside A1 Suppresses Autophagy by Inhibiting Cathepsin C and Reduces the Growth of Colon CancerCancersFebruary 16, 2023Kim S, Lee KH, Choi HJ, Kim E, Kang S, Han M, Jeon HJ, Yun MY, Song GY, Lee HJ.

(13) A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeuticNatureMay 1, 2022Shapira T, Monreal IA, Dion SP, Buchholz DW, Imbiakha B, Olmstead AD, Jager M, Désilets A, Gao G, Martins M, et al.

(14) Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegenerationScience advancesApril 15, 2022Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, Söding J, Klemp H, Bellotti C, Stäuble A, et al.

(15) Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosisNatureFebruary 1, 2022Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, et al.Z-DEVD-fmk, and pan-caspase inhibitor Z-VAD-fmk, and recombinant human cathepsin B (953-CY-010), cathepsin L (952-CY-010), cathepsin D (1014-AS-010) were from R&D Systems. Blasticidin (anti-bl) and puromycin (anti-pr) were

(16) Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine ProteasesACS Chemical NeuroscienceJanuary 19, 2022Michael C. Yoon, Janneca Ames, Charles Mosier, Zhenze Jiang, Sonia Podvin, Anthony J. O’Donoghue, Vivian Hookindicated) were obtained from R&D Systems (Minneapolis, MN), consisting of human recombinant cathepsin L (#952-CY-010), human recombinant cathepsin V (#1080-CY-010), human recombinant PC1/3 (#2810-SE-010), and human recombinant

(17) Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification, and CharacterizationToxinsDecember 2, 2021Linhares DDC, Faria F, Kodama RT, Amorim AMXP, Portaro FCV, Trevisan-Silva D, Ferraz KF, Chudzinski-Tavassi AM.

(18) Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary InfectionPharmaceuticsOctober 11, 2021Li J, Liu S, Shi J, Zhu HJ.

(19) Direct Intracellular Visualization of Ebola Virus-Receptor Interaction by In Situ Proximity LigationmBioJanuary 12, 2021Mittler E, Alkutkar T, Jangra RK, Chandran K.

(20) Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin CAmerican journal of cancer researchJanuary 1, 2021Kim S, Lee SI, Kim N, Joo M, Lee KH, Lee MW, Jeon HJ, Ryu H, Kim JM, Sul JY, et al.

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Recombinant Human Cathepsin L Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Cathepsin L Protein, CF from R&D Systems, a Bio-Techne Brand

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