Fig 1: Skin care ingredients significantly suppressed the releases of IGFBP3 and NGF from doxorubicin-induced senescent keratinocytes. (a) IGFBP3 and (b) NGF protein levels in media from senescent keratinocytes were measured following 72 h of treatment with various skin care ingredients: N(pH7): 1/50 dilution of 5% niacinamide at pH 7; N(pH4): 1/50 dilution of 5% niacinamide at pH 4 adjusted with hydrochloric acid; GLAB: 0.00125% Glabridin, SDL: 0.001% sucrose dilaurate; TxA: 0.1% tranexamic acid. For each ingredient, the maximum concentration without affecting cell viability was tested. The detected amounts were normalized to sKC NT control levels. Bar indicates mean + SD (N = 6; * p < 0.05 vs. sKC NT control, one-way ANOVA followed by Tukey’s multiple comparison test). KC: keratinocyte; sKC: senescent keratinocyte; NT: no treatment.