Recombinant Human/Mouse FGF-8b Protein 423-F8-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human/Mouse FGF-8b Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $334.00Supplier Page View Company Product Page
Catalog Number423-F8-025
SpeciesHuman, Mouse
Molecule NameFGF-8
Size25 ug (also 1 mg)
NCBI Full Gene Namefibroblast growth factor 8
NCBI Gene AliasesHH6, AIGF, FGF-8, HBGF-8, Fgf6c, KAL6, Aigf, Fgf-8
FormatLyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4 and Brij-35 with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 23 kDa, reducing conditions
Theoretical: 22.5 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human/Mouse FGF-8b Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Human macula formation involves two waves of retinoic acid suppression via CYP26A1 that modulate cell cycle exit and cone subtype specificationStem cell reportsOctober 14, 2025Harding P, Wojtynska M, Smith AJ, Ali RR, Pearson RA.supplementary material. For dosing, 10 μM AGN193019 (Bioteche: 5758) or 100 ng/μL rFGF8 (Biotechne: 423-F8-025) were added to culture media every 2 days throughout the dosing windows. RNAscope in situ hybridization RNAscope

(2) A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brainCell reportsOctober 22, 2024Silenzi V, D'Ambra E, Santini T, D'Uva S, Setti A, Salvi N, Nicoletti C, Scarfò R, Cordella F, Mongiardi B, et al.

(3) Human IPSC‐Derived PreBötC‐Like Neurons and Development of an Opiate Overdose and Recovery ModelAdvanced BiologyAugust 1, 2024Xiufang Guo, Nesar Akanda, Gabriella Fiorino, Siddharth Nimbalkar, Christopher J. Long, Alisha Colón, Aakash Patel, Patrick J. Tighe, James J. Hickmanchange. 24 hours later, the medium was changed to TesR ™ -E6 medium containing 200 ng ml−1 FGF8b (R&D, 423-F8-025). After another 24 hour period, the cells are replated utilizing accutase again, to detach the cells

(4) Ligand bias underlies differential signaling of multiple FGFs via FGFR1eLifeApril 3, 2024Karl K, Del Piccolo N, Light T, Roy T, Dudeja P, Ursachi VC, Fafilek B, Krejci P, Hristova K.DMEM without fetal bovine serum. Varying amounts of ligands (R&D Systems; FGF4, #235-F4-025; FGF8, #423-F8-025, and FGF9, # 273-F9-025) were added to each well to create a ligand concentration gradient. Cells were

(5) Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neuronsNeural regeneration researchApril 1, 2024Chen Y, Kuang J, Niu Y, Zhu H, Chen X, So KF, Xu A, Shi L.(100 ng/mL, R&D System, Minneapolis, MN, USA, Cat# 464-SH-025) and FGF8 (100 ng/mL, R&D System, Cat# 423-F8-025). Next, NPC were cultured according to the optimized dual SMAD pathway inhibition protocol with the

(6) Functional analysis of a first hindlimb positioning enhancer via Gdf11 expressionFront Cell Dev BiolMarch 15, 2024Seiji Saito, Utsugi Kanazawa, Ayana Tatsumi, Atsuo Iida, Tatsuya Takemoto, Takayuki SuzukiBSA/PBS (FUJIFILM Wako, Japan; 013–15104) solution or 100 ng/μL or 500 ng/μL FGF8b (R&D systems, MN, USA; 423-F8-025)/0.1% BSA solution and allowed to adsorb proteins for 1 h at room temperature. The beads were then implanted

(7) Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cellsPeptidesMarch 1, 2024Miwata T, Suga H, Mitsumoto K, Zhang J, Hamada Y, Sakakibara M, Soen M, Ozaki H, Asano T, Miyata T, et al.

(8) Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitorsDevelopmental CellFebruary 5, 2024Yuji Atsuta, ChangHee Lee, Alan R. Rodrigues, Charlotte Colle, Reiko R. Tomizawa, Ernesto G. Lujan, Patrick Tschopp, Laura Galan, Meng Zhu, Joshua M. Gorham, et al.Express,gibco,12605–010 2-Mercaptoethanol,gibco,21985–023 MEM NEAA,gibco,11140–050 Chir99021,Tocris,4423 Fgf8b,R&D Systems,423-F8-025 atRA,Tocris,0695 SB431542,Sigma-Aldrich,S4317-5MG Y-27632,Cayman Chemical,10005583 "BIOMIMESYS,

(9) Protocol for 3D Bioprinting Mesenchymal Stem Cell-derived Neural Tissues Using a Fibrin-based BioinkBio-protocolMay 5, 2023Perez MR, Masri NZ, Walters-Shumka J, Kahale S, Willerth SM.working volumes. Avoid thaw/freeze cyclesFibroblast growth factor 8 (FGF8) (R&D Systems, catalog number: 423-F8-025); storage: -80 °C. Aliquot the reagent into working volumes. Avoid thaw/freeze cyclesLDN-193189 (STEMCELL Technologies

(10) Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomerseLifeJanuary 10, 2023Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R.

(11) A reference human induced pluripotent stem cell line for large-scale collaborative studiesCell stem cellDecember 1, 2022Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, et al.

(12) Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-proteinCell reportsOctober 25, 2022Park JS, Choi J, Cao L, Mohanty J, Suzuki Y, Park A, Baker D, Schlessinger J, Lee S.recombinant proteins" FGF2,Gibco,Cat# PHG0367 FGF5,R&D systems,Cat# 237-F5-050 FGF8b,R&D systems,Cat# 423-F8-025 FGF18,Peprotech,Cat# 100-28 Heparin octa-saccharide (Dp10),Iduron,Cat# HO10 Heparin sepharose resin

(13) Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive stateScientific reportsOctober 17, 2022Ozaki H, Suga H, Sakakibara M, Soen M, Miyake N, Miwata T, Taga S, Nagai T, Kano M, Mitsumoto K, et al.

(14) Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney diseaseKidney internationalAugust 1, 2022Yanucil C, Kentrup D, Campos I, Czaya B, Heitman K, Westbrook D, Osis G, Grabner A, Wende AR, Vallejo J, et al.

(15) Sonic hedgehog is Essential for Proximal-Distal Outgrowth of the Limb Bud in SalamandersFrontiers in Cell and Developmental BiologyApril 1, 2022Sruthi Purushothaman, Brianda B. Lopez Aviña, Ashley W. Seifertof SHH-N protein for 2 h at room temperature or overnight at 4°C. FGF-8b protein (R&D Systems, cat#423-F8-025) was reconstituted in 1× PBS with 0.1% BSA. Each heparin/agarose bead (Sigma-Aldrich, cat#H6508) was

(16) Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer ProgressionCancersJanuary 7, 2022Yu L, Toriseva M, Afshan S, Cangiano M, Fey V, Erickson A, Seikkula H, Alanen K, Taimen P, Ettala O, et al.

(17) Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem CellsStem cells internationalJanuary 1, 2022Lee DS, Song YJ, Gug HR, Lee JH, Bae HS, Park JC.

(18) Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cellseLifeNovember 29, 2021Behesti H, Kocabas A, Buchholz DE, Carroll TS, Hatten ME.,R&D Systems,Catalog # 507BP-020, "Peptide, recombinant protein",Human/mouse FGF8b,R&D Systems,Catalog # 423-F8-025, Commercial assay or kit,RNeasy micro kit,QIAGEN,Catalog # 74004, Commercial assay or kit,RNeasy Plus

(19) Induction of γδT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cellsJournal of cellular and molecular medicineNovember 1, 2021Hosaka N, Kanda S, Shimono T, Nishiyama T.

(20) Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary developmenteLifeOctober 13, 2021Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM.R2625); 100 ng/ml WNT2B (R&D Systems 3900-WN-025); 1 μM DEAB (Sigma D86256); 100 ng/ml FGF8b (R&D Systems 423-F8-025); and 0.5 μM ketoconazole (Tocris 1103). In CHX experiments, explants were treated for 2 hr in CHX prior

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Recombinant Human/Mouse FGF-8b Protein from R&D Systems, a Bio-Techne Brand

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