IGF-II/IGF2 Protein 292-G2-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIGF-II/IGF2 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $223.00Supplier Page View Company Product Page
Catalog Number292-G2-050
SpeciesHuman
Size50 ug (also 250 ug)
FormatLyophilized from a 0.2 µm filtered solution in Acetic Acid
Molecule NameIGF-II/IGF2
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Source/Expression SystemE. coli-derived Recombinant Human IGF-II/IGF2 Protein, CF
NCBI Gene AliasesSRS3, GRDF, C11orf43, PP9974, IGF-II
NCBI Full Gene Nameinsulin like growth factor 2

Specifications/Features

Available conjugates: Sizes Available: 50 ug (also 250 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model miceStem Cell Research & TherapyOctober 7, 2024Megumi Yokomizo-Goto, Nana Takenaka-Ninagawa, Chengzhu Zhao, Clémence Kiho Bourgeois Yoshioka, Mayuho Miki, Souta Motoike, Yoshiko Inada, Denise Zujur, William Theoputra, Yonghui Jin, et al.seeded in COL1-coated 24-well plates. In the IGF2 supplementation group, Recombinant Human IGF-II (292-G2-050, R&D Systems) was added at a concentration of 3.6 ng/ml in MuSC expansion medium on days 1 to 3 and

(2) Skeletal overgrowth in a pre-pubescent child treated with pan-FGFR inhibitorHeliyonJune 15, 2024Majlessipour F, Zhu G, Baca N, Kumbaji M, Hwa V, Danielpour M.FGF2 (R&D Systems, Cat No. 233-FB-01 M), IGF-I (Gibco, Cat No. PHG0078), or IGF2 (R&D Systems, Cat No. 292-G2-050), in co-treatment experiments. The 5 mM erdafitinib concentrated stock solution was dissolved in 2 %

(3) Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteriesbioRxiv : the preprint server for biologyJune 12, 2024Abello J, Yin Y, Zhao Y, Maurer J, Lee J, Bodell C, Clevenger AJ, Burton Z, Goeckel ME, Lin M, et al.

(4) Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1bioRxiv : the preprint server for biologyApril 1, 2024Johnson D, Colijn S, Richee J, Yano J, Burns M, Davis AE, Pham VN, Saric A, Jain A, Yin Y, et al.

(5) Effect of IGFBP-4 during In Vitro Maturation on Developmental Competence of Bovine Cumulus Oocyte ComplexesAnimals (Basel)February 21, 2024Adriana Raquel Camacho de Gutiérrez, Oguz Calisici, Christine Wrenzycki, Juan Carlos Gutiérrez-Añez, Christine Hoeflich, Andreas Hoeflich, Árpád Csaba Bajcsy, Marion Schmickewith rbIGFBP-4 (2000 ng/mL) and recombinant human IGF-2 at 100 ng/mL, as well as 50 ng/mL (rhIGF-2, 292-G2-050; R&D systems, Bio-techne, Abingdon, UK). The IGF-2 concentrations were chosen based on those in the

(6) CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitmentbioRxiv : the preprint server for biologySeptember 17, 2023Goeckel ME, Lee J, Levitas A, Colijn S, Mun G, Burton Z, Chintalapati B, Yin Y, Abello J, Stratman A.

(7) The Role of SOX9 in IGF-II-Mediated Pulmonary FibrosisInternational journal of molecular sciencesJuly 8, 2023Waldrep KM, Rodgers JI, Garrett SM, Wolf BJ, Feghali-Bostwick CA.

(8) Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytesExperimental gerontologyFebruary 1, 2023Conover CA, Bale LK.

(9) The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYCCell reportsDecember 6, 2022Lee JS, Lero MW, Mercado-Matos J, Zhu S, Jo M, Tocheny CE, Morgan JS, Shaw LM.

(10) Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cellsNature communicationsMay 26, 2021Funakoshi S, Fernandes I, Mastikhina O, Wilkinson D, Tran T, Dhahri W, Mazine A, Yang D, Burnett B, Lee J, et al.

(11) Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitmentCommunications biologyDecember 4, 2020Stratman AN, Burns MC, Farrelly OM, Davis AE, Li W, Pham VN, Castranova D, Yano JJ, Goddard LM, Nguyen O, et al.

(12) Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and functionPLoS geneticsOctober 1, 2020Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, et al.technologies) and transferred to nitrocellulose membranes (Invitrogen). 4 ng human recombinant IGF2 (292-G2-050, R&D Systems) was used as positive control, and the Novex Sharp protein ladder (Life technologies) was

(13) Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21AgingApril 17, 2020Mercurio L, Lulli D, Mascia F, Dellambra E, Scarponi C, Morelli M, Valente C, Carbone ML, Pallotta S, Girolomoni G, et al.

(14) Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cellsScientific reportsFebruary 10, 2020Rooda I, Hensen K, Kaselt B, Kasvandik S, Pook M, Kurg A, Salumets A, Velthut-Meikas A.

(15) Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environmentsScience advancesFebruary 1, 2020Wang R, Qi X, Schmiege P, Coutavas E, Li X.

(16) Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profilesScientific reportsJune 6, 2019Fredolini C, Byström S, Sanchez-Rivera L, Ioannou M, Tamburro D, Pontén F, Branca RM, Nilsson P, Lehtiö J, Schwenk JM.from Hanna Tegel and Johan Rockberg (AlbaNova University Center, KTH). IGF-II (R&D systems, catalog # 292-G2-050, lot DS2416011) and BCHE (DuoSet kit R&D systems, Catalog # DY6137-05, lot # 1387842) were commercially

(17) Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasisBMC cancerFebruary 7, 2019De Giovanni C, Nanni P, Landuzzi L, Ianzano ML, Nicoletti G, Croci S, Palladini A, Lollini PL.

(18) Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytesPhysiological reportsFebruary 1, 2019Conover CA, Bale LK, Frye RL, Schaff HV.

(19) Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditionsPloS oneJanuary 1, 2019Garrett SM, Hsu E, Thomas JM, Pilewski JM, Feghali-Bostwick C.

(20) Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodiesProceedings of the National Academy of Sciences of the United States of AmericaJanuary 30, 2018Jalili R, Horecka J, Swartz JR, Davis RW, Persson HHJ.

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Recombinant Human IGF-II/IGF2 Protein, CF

IGF-II/IGF2 Protein

IGF-II/IGF2 Protein

IGF-II/IGF2 Protein

IGF-II/IGF2 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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IGF-II/IGF2 Protein from R&D Systems, a Bio-Techne Brand

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