Recombinant Human Leptin Protein, CF 398-LP-01M from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Leptin Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $257.00Supplier Page View Company Product Page
Catalog Number398-LP-01M
Size1 mg (also 5 mg)
ApplicationsBioactivity
FormatLyophilized from a 0.2 µm filtered solution in Tris-HCl and NaCl
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular Weight16 kDa
Conjugate/TagUnconjugated
SpeciesHuman
Molecule NameLeptin/OB
Source/Expression SystemE. coli-derived Recombinant Human Leptin Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution
NCBI Full Gene Nameleptin
NCBI Gene AliasesLEPD, OB, OBS

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantationCell Stem CellAugust 7, 2025J. Jeya Vandana, Jiajun Zhu, Alice Maria Giani, Tuo Zhang, Lauretta A. Lacko, Dongliang Leng, D. Leland Taylor, Brian N. Lee, Zhaowei Han, Tiancheng Jiao, et al.1,Peprotech,100-11 Irisin,R&D Systems,8880-IR-25/CF Kisspeptin,R&D Systems,2570/1 Leptin,R&D Systems,398-LP-01M "Lipotropin (beta-lipotropin 61–91, beta-endorphin)",Sigma-Aldrich,E6261 Luteinizing hormone,Sigma-Aldrich,L6420 Melanocyte

(2) Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulationMolecular psychiatryMay 1, 2025Giuranna J, Zheng Y, Brandt M, Jall S, Mukherjee A, Shankhwar S, Renner S, Kurapati NK, May C, Peters T, et al.

(3) Effects of a Paleolithic diet compared to a diabetes diet on leptin binding inhibition in secondary analysis of a randomised cross-over studyBMC endocrine disordersSeptember 4, 2024Fontes-Villalba M, Granfeldt Y, Sundquist K, Memon AA, Hedelius A, Carrera-Bastos P, Jönsson T.

(4) Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in miceMolecular metabolismMay 1, 2024Akindehin S, Liskiewicz A, Liskiewicz D, Bernecker M, Garcia-Caceres C, Drucker DJ, Finan B, Grandl G, Gutgesell R, Hofmann SM, et al.

(5) The effect of leptin on trained innate immunity and on systemic inflammation in subjects with obesityJournal of leukocyte biologyJanuary 19, 2024Flores Gomez D, Bekkering S, Ter Horst R, Cossins B, van den Munckhof ICL, Rutten JHW, Joosten LAB, Netea MG, Riksen NP.

(6) Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal ModelPharmaceuticsJanuary 16, 2024Masloh S, Chevrel A, Culot M, Perrocheau A, Kalia YN, Frehel S, Gaussin R, Gosselet F, Huet S, Zeisser Labouebe M, et al.

(7) Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsetsScientific reportsJanuary 3, 2024Pries R, Kosyna FK, Depping R, Plötze-Martin K, Lange C, Meyhöfer S, Meyhöfer SM, Marquardt JU, Bruchhage KL, Steffen A.

(8) Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathwayCell death & diseaseFebruary 9, 2023Wei J, Huang X, Zhang X, Chen G, Zhang C, Zhou X, Qi J, Zhang Y, Li X.

(9) Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null MiceInternational journal of molecular sciencesJanuary 21, 2023Kayashima Y, Townley-Tilson WHD, Vora NL, Boggess K, Homeister JW, Maeda-Smithies N, Li F.analysis. Insulin was purchased from Sigma-Aldrich (#91077C, St. Louis, MO, USA); leptin from R&D Systems (#398LP01M). Experiments were repeated two times with each experimental group consisted of 3 replicates 4.5. Other

(10) Leptin-producing monocytes in the airway submucosa may contribute to asthma pathogenesisRespiratory investigationJanuary 1, 2023Watanabe K, Suzukawa M, Kawauchi-Watanabe S, Igarashi S, Asari I, Imoto S, Tashimo H, Fukami T, Hebisawa A, Tohma S, et al.

(11) Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROSMechanisms of ageing and developmentDecember 1, 2022Mourmoura E, Papathanasiou I, Trachana V, Konteles V, Tsoumpou A, Goutas A, Papageorgiou AA, Stefanou N, Tsezou A.

(12) Role of leptin/ILC2 axis in allergic rhinitis in obese childrenInternational journal of pediatric otorhinolaryngologyJune 1, 2022Wang X, Shen Y, Ke X, Kang H, Hong S.

(13) Leptin-mediated proinflammatory bone marrow environment in acquired aplastic anemiaCytokineApril 1, 2022Gao M, Ge M, Huo J, Ren X, Li X, Shao Y, Huang J, Zhang J, Wang M, Nie N, et al.

(14) The Role of Leptin in Childhood Immune Thrombocytopenia (ITP): An Anti-Inflammatory Agent?International journal of molecular sciencesJuly 16, 2021Thomas I, Panagoulias I, Aggeletopoulou I, Varvarigou A, Spiliotis BE, Mouzaki A.

(15) Diverse functional autoantibodies in patients with COVID-19NatureJuly 1, 2021Wang EY, Mao T, Klein J, Dai Y, Huck JD, Jaycox JR, Liu F, Zhou T, Israelow B, Wong P, et al.(PeproTech, 200–13), IL-1α (RayBiotech, 228–10846-1), IL-6 (produced in-house), Leptin (R&D Systems, 398-LP-01M), SLC2A12-mIgG2a-Fc (produced in-house), TSLP (PeproTech, 300–62), IL-18Rβ (produced in-house). Functional

(16) Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob MiceMetabolitesJune 14, 2021Leibiger B, Moede T, Valladolid-Acebes I, Paschen M, Visa M, Leibiger IB, Berggren PO.

(17) Leptin Promotes Greater Ki67 Expression in CD4⁺ T Cells From Obese Compared to Lean Persons Living With HIVFrontiers in immunologyJanuary 1, 2021Fuseini H, Smith R, Nochowicz CH, Simmons JD, Hannah L, Wanjalla CN, Gabriel CL, Mashayekhi M, Bailin SS, Castilho JL, et al.pre-treated with 0, 5, 10, 50, and 100 nM concentrations of recombinant leptin (R and D systems, Catalog No. 398-LP-01M) for 48 hours in serum-free media (Lonza X VIVO 10 with Gentamicin, Catalog No. 04-380Q). Leptin stock

(18) Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health ProjectNutrientsNovember 30, 2020Crabtree DR, Buosi W, Fyfe CL, Horgan GW, Manios Y, Androutsos O, Giannopoulou A, Finlayson G, Beaulieu K, Meek CL, et al.

(19) Chronic G_q signaling in AgRP neurons does not cause obesityProceedings of the National Academy of Sciences of the United States of AmericaAugust 25, 2020Ewbank SN, Campos CA, Chen JY, Bowen AJ, Padilla SL, Dempsey JL, Cui JY, Palmiter RD.

(20) A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein InteractionsCellAugust 20, 2020Woj M. Wojtowicz, Jost Vielmetter, Ricardo A. Fernandes, Dirk H. Siepe, Catharine L. Eastman, Gregory B. Chisholm, Sarah Cox, Heath Klock, Paul W. Anderson, Sarah M. Rue, et al.,R&D Systems,Cat#923-AN-025/CF Recombinant Human β-NGF,R&D Systems,Cat#256-GF/CF "Recombinant Human Leptin Protein, CF",R&D Systems,Cat#398-LP-01M "Recombinant Mouse Leptin Protein, CF",R&D Systems,Cat#498-OB-01M Recombinant protein A,Thermo Fisher Scientific

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Recombinant Human Leptin Protein, CF

Leptin/OB Protein

Leptin/OB Protein

Leptin/OB Protein

Leptin/OB Protein

Recombinant Human Leptin Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Leptin Protein, CF from R&D Systems, a Bio-Techne Brand

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