CCL2/JE/MCP-1 Protein 479-JE-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCCL2/JE/MCP-1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $288.00Supplier Page View Company Product Page
Catalog Number479-JE-010
SpeciesMouse
Size10 ug (also 50 ug)
Molecule NameCCL2/JE/MCP-1
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
NCBI Full Gene NameC-C motif chemokine ligand 2, chemokine (C-C motif) ligand 2
NCBI Gene AliasesMCP1, Scya2, MCAF, Sigje, HSMCR30, JE, HC11, SMC-CF, GDCF-2, SCYA2, MCP-1
Source/Expression SystemE. coli-derived Recombinant Mouse CCL2/JE/MCP-1 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 10 ug (also 50 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A medium-chain fatty acid analogue prevents endotoxin liver injury in a murine modelScientific reportsApril 20, 2025Wang SZ, Hirsch TI, Fligor SC, Tsikis ST, Pan A, Quigley M, Mitchell PD, Gura KM, Fraser DA, Puder M.

(2) Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured heartsCell ReportsMarch 25, 2025Yuriko Terada, Wenjun Li, Junedh M. Amrute, Amit I. Bery, Charles R. Liu, Venkatrao Nunna, Christian Corbin Frye, Hao Dun, Andrew L. Koenig, Hannah P. Luehmann, et al.,R&D systems,Cat# 450-MA-010 Recombinant CCL4,R&D systems,Cat# 451-MB-010 Recombinant CCL2,R&D systems,Cat# 479-JE-010 Recombinant CCL7,R&D systems,Cat# 456-MC-010 Recombinant CXCL5,R&D systems,Cat# 433-MC-025 CCL3/MIP-1

(3) Inhibition of Notch enhances efficacy of immune checkpoint blockade in triple-negative breast cancerScience advancesNovember 1, 2024Shen Q, Murakami K, Sotov V, Butler M, Ohashi PS, Reedijk M.

(4) CCL2 signaling promotes skeletal muscle wasting in non-tumor and breast tumor modelsDisease models & mechanismsAugust 1, 2024Alissa N, Fang WB, Medrano M, Bergeron N, Kozai Y, Hu Q, Redding C, Thyfault J, Hamilton-Reeves J, Berkland C, et al.

(5) Sepsis-trained macrophages promote antitumoral tissue-resident T cellsNature immunologyMay 1, 2024Broquet A, Gourain V, Goronflot T, Le Mabecque V, Sinha D, Ashayeripanah M, Jacqueline C, Martin P, Davieau M, Boutin L, et al.

(6) Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung InflammationNutrientsNovember 9, 2023Hong J, Son M, Sin J, Kim H, Chung DK.

(7) Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine releaseNature communicationsOctober 9, 2023Adrian M, Weber M, Tsai MC, Glock C, Kahn OI, Phu L, Cheung TK, Meilandt WJ, Rose CM, Hoogenraad CC.

(8) VDUP1 Deficiency Promotes the Severity of DSS-Induced Colitis in Mice by Inducing Macrophage InfiltrationInternational journal of molecular sciencesSeptember 1, 2023Park KH, Lee H, Kim HC, Choi I, Han SB, Kang JS.

(9) Citrullinated fibrinogen-SAAs complex causes vascular metastagenesisNature communicationsAugust 24, 2023Han Y, Tomita T, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, et al.

(10) Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunityCell reportsJanuary 31, 2023Liu J, Cheng Y, Zhang X, Chen Y, Zhu H, Chen K, Liu S, Li Z, Cao X.

(11) Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding functionPloS oneJanuary 1, 2023Su Z, Brooks J, Pelker J, Andreyeva T, Sobon H, Gifford R, Powers M, Wang J, Dower C, Hegen M, et al.

(12) Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular diseaseJournal of neuroinflammationAugust 8, 2022Rajesh A, Droho S, Lavine JA.

(13) Microglia coordinate cellular interactions during spinal cord repair in miceNature communicationsJuly 14, 2022Brennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, Pukos N, Campbell WA, Witcher KG, Guan Z, et al.

(14) Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosisCell death & diseaseMay 31, 2022Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, Ding K, Zheng S, Yang N, Zhang Z, et al.include the following: anti-α-smooth actin (Santa Cruz Biotechnology, sc-130616), anti-MCP1 (R&D systems, 479-JE-010; Novus Biologicals, NBP2-22115), anti-active caspase 1 (Invitrogen, AAC504N), anti-NLRP3 (AdipoGen,

(15) Histone functions as a cell-surface receptor for AGEsNature communicationsMay 27, 2022Itakura M, Yamaguchi K, Kitazawa R, Lim SY, Anan Y, Yoshitake J, Shibata T, Negishi L, Sugawa H, Nagai R, et al.

(16) Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancerEBioMedicineMay 1, 2022Ye L, Jin K, Liao Z, Xiao Z, Xu H, Lin X, Li H, Li T, Zhang W, Han X, et al.

(17) Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific mannerNature communicationsFebruary 10, 2022Ahn YJ, Wang L, Tavakoli S, Nguyen HN, Short JD, Asmis R.

(18) A chemokine regulatory loop induces cholesterol synthesis in lung-colonizing triple-negative breast cancer cells to fuel metastatic growthMolecular therapy : the journal of the American Society of Gene TherapyFebruary 2, 2022Han B, Alonso-Valenteen F, Wang Z, Deng N, Lee TY, Gao B, Zhang Y, Xu Y, Zhang X, Billet S, et al.(276-GB-010, R&D Systems), recombinant human CXCL8 (208-IL-010, R&D Systems), recombinant mouse Ccl2 (479-JE-010, R&D Systems), recombinant mouse Ccl7 (456-MC-010, R&D Systems), GGTI-2133 (G5294, Sigma-Aldrich), FTI-277

(19) Selective Immune Modulating Activities of Viscum album and Its Components; A Possibility of Therapeutics on Skin Rash Induced by EGFR InhibitorsIntegrative cancer therapiesJanuary 1, 2022Choi HJ, Park SJ, Choi YN, Kim SD, Kwag EB, Song SY, Park JH, Kim JK, Seo C, Choi JJ, et al.

(20) Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2(+)/CX3CR1(+) M-MDSCs into the tumor microenvironment in a redundant mannerFrontiers in immunologyJanuary 1, 2022Takacs GP, Kreiger CJ, Luo D, Tian G, Garcia JS, Deleyrolle LP, Mitchell DA, Harrison JK.Mouse CCL2, CCL7, and soluble CX3CL1 chemokines were purchased from R & D Systems (product numbers 479-JE-010; 456-MC-010; 571-MF-025). Recombinant proteins were reconstituted following manufacture preparation

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Recombinant Mouse CCL2/JE/MCP-1 Protein

CCL2/JE/MCP-1 Protein

CCL2/JE/MCP-1 Protein

CCL2/JE/MCP-1 Protein

CCL2/JE/MCP-1 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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CCL2/JE/MCP-1 Protein from R&D Systems, a Bio-Techne Brand

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