IL-1 beta/IL-1F2 Protein 401-ML-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-1 beta/IL-1F2 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $303.00Supplier Page View Company Product Page
Catalog Number401-ML-005
SpeciesMouse
Molecule NameIL-1 beta/IL-1F2
Size5 ug (also 10 ug, 25 ug, 100 ug)
NCBI Full Gene Nameinterleukin 1 beta
NCBI Gene AliasesIL1-BETA, IL-1, IL-1beta, IL1F2, Il-1b, IL1beta
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Mouse IL-1 beta/IL-1F2 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 5 ug (also 10 ug, 25 ug, 100 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Inflammatory Mediators Both Directly and Indirectly Promote Microglial ProliferationGliaMarch 19, 2026Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemel(IL17A; Gibco 210‐17), interleukin‐1ɑ (IL1ɑ; R&D Systems 400‐ML‐005), interleukin‐1β (IL1β; R&D Systems 401‐ML‐005), interleukin‐33 (IL33; Gibco 210–33), interleukin‐4 (IL4; Gibco 214–14), interleukin‐5 (IL5; Gibco

(2) Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophilseLifeSeptember 12, 2025Ravesloot-Chavez MM, Van Dis E, Fox D, Anaya-Sanchez A, Espich S, Nguyenla XH, Rawal S, Samani H, Ballinger M, Thomas HF, et al.of 50 μl of cell-free lung homogenates and 50 μl of media), or recombinant mouse IL-1β (R&D Systems 401-ML-005). Assays were developed using QUANTI-Blue (InvivoGen) according to the manufacturer’s protocols and

(3) Sorafenib inhibits multiple sclerosis by regulating T cell differentiationCellular signallingSeptember 1, 2025Wang H, Wang S, Wang J, Fang Y, Li J, Shen Y, Guo J.

(4) TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathwayJournal of advanced researchSeptember 1, 2025Sun K, Zhang X, Hou L, Lu F, Liu H, Zheng Z, Guo Z, Xu J, Ruan Z, Hou Y, et al.

(5) Inflammatory Oxidative Stress Compounds Inhibit Insulin Secretion through Rapid Protein CarbonylationbioRxiv : the preprint server for biologyJuly 26, 2025Saunders EF, Schultz KR, Lowe I, Anderson AL, Bikkumalla VS, Soto D, Tran NY, Baumel-Alterzon S, Knight JD, Shearn CT.

(6) Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammationNatureJuly 1, 2025White Z, Cabrera I, Mei L, Clevenger M, Ochoa-Raya A, Kapustka I, Dominguez JR, Zhou J, Koster KP, Anwar S, et al.

(7) Circadian synchronization differentially modifies cytokine-mediated transcriptomic remodeling and cell death in INS-1 cells and mouse isletsiScienceMay 16, 2025Phillip Alexander Keller Andersen, Rasmus H. Reeh, Isabel Sanders, Emilie Bender Overlund, Georgia Katsioudi, Cecilia Jiménez-Sánchez, Emil Zeng Skovhøj, Anniek Frederike Lubberding, Charna Dibner, Thomas Mandrup-PoulsenN0636 Penicillin-Streptomycin,Thermo Fischer Scientific (Gibco™),Cat# 15140122 Recombinant Mouse IL-1β,R&D Systems,Cat# 401-ML-005 Recombinant Rat IFN-γ,R&D Systems,Cat# 585-IF-100 "RPMI 1640 Medium, GlutaMAX™ Supplement",Thermo Fischer Scientific

(8) Psychedelic control of neuroimmune interactions governing fearNatureMay 1, 2025Chung EN, Lee J, Polonio CM, Choi J, Akl CF, Kilian M, Weiß WM, Gunner G, Ye M, Heo TH, et al.astrocyte–neuron cultures: 50 ng ml−1 TNF (R&D Systems, 410-MT-010); 100 ng ml−1 IL-1β (R&D Systems, 401-ML-005); 100 ng ml−1 IL-12 (Pepro-Tech, 210-12); and 200 ng ml−1 corticosterone. The corticosterone dose was

(9) Modulation of gut propionate and intestinal mucosal protection by Bifidobacterium longum: Mitigating methotrexate side effects without compromising the efficacy of psoriasis therapyInternational immunopharmacologyMarch 6, 2025Mao M, Yuan Y, Li R, Kuang Y, Lu Y, Zhu W, Chen W.

(10) CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse modelNature NeuroscienceMarch 3, 2025Atsushi Kadowaki, Michael A. Wheeler, Zhaorong Li, Brian M. Andersen, Hong-Gyun Lee, Tomer Illouz, Joon-Hyuk Lee, Alain Ndayisaba, Stephanie E. J. Zandee, Himanish Basu, et al.astrocyte cultures. TNF/IL-1β treatment (50 ng ml−1 TNF (410-MT-010, R&D Systems) and 100 ng ml−1 IL-1β (401-ML-005, R&D Systems)) was performed with the cytokines diluted in DMEM + FBS + penicillin–streptomycin. Then,

(11) Droplet-based functional CRISPR screening of cell-cell interactions by SPEAC-seqNature protocolsFebruary 1, 2025Faust Akl C, Linnerbauer M, Li Z, Lee HG, Clark IC, Wheeler MA, Quintana FJ.from Escherichia coli 0111:B4 (Invivogen, cat. no. tlrl-eblps)Recombinant IL-1β (R&D Systems, cat. no. 401-ML-005)Recombinant TNF-alpha (R&D Systems, cat. no. 410-MT-010) Buffers and molecular biology Ex Taq DNA

(12) RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritisInternational immunopharmacologyJanuary 10, 2025Xu J, Wang G, Hou Y, Sun K, Zheng Z, Guo Z, Hou L, Zhang X, Ruan Z, Ye Y, et al.

(13) BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2International journal of biological sciencesJanuary 1, 2025Li S, Luo D, Liang Y, Zou Y, Pu H, Zheng M, Wang Y, Sun X, Zhu H, Zhu Y, et al.

(14) InTraSeq: A Multimodal Assay that Uncovers New Single-Cell Biology and Regulatory MechanismsResearch squareDecember 9, 2024Beausoleil S, Ariss M, Huang L, Ding X, Sheth S, Levy T, Fisher J, Loebelenz J, Arlotta K, Dixon K, et al.

(15) LTβR Agonism Promotes Antitumor Immune Responses via Modulation of the Tumor MicroenvironmentCancer researchDecember 2, 2024An D, Chen G, Cheng WY, Mohrs K, Adler C, Gupta NT, Atwal GS, DiLillo DJ, Daly C, Lin JC, et al.

(16) Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signalingJournal of neuroinflammationNovember 19, 2024Nemeth DP, Liu X, Monet MC, Niu H, Maxey G, Schrier MS, Smirnova MI, McGovern SJ, Herd A, DiSabato DJ, et al.intra-hippocampus injections, AP, +/-1.8; ML, +/-1.8; DV, -1.7. 20 ng recombinant mouse IL-1β (R&D System, Cat 401-ML-005) in 2 µl of saline, 1 × 109 GC AAV2-CMV-Cre-eGFP (Cat: #105530-AAV2, RRID: Addgene_105545) or 1 × 109

(17) CD73 alleviates osteoarthritis by maintaining anabolism and suppressing catabolism of chondrocytes extracellular matrixJournal of orthopaedic translationNovember 1, 2024Guo H, Lv Z, Wang M, Li W, Xie Y, Liu Z, Chen F, Jiang R, Liu Y, Wu R, et al.

(18) Inhibition of Notch enhances efficacy of immune checkpoint blockade in triple-negative breast cancerScience advancesNovember 1, 2024Shen Q, Murakami K, Sotov V, Butler M, Ohashi PS, Reedijk M.

(19) GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylationJournal of translational medicineOctober 21, 2024Liu C, Zhang Q, Zhou H, Jin L, Liu C, Yang M, Zhao X, Ding W, Xie W, Kong H.

(20) BACH2 regulates diversification of regulatory and proinflammatory chromatin states in T(H)17 cellsNature immunologyAugust 1, 2024Thakore PI, Schnell A, Huang L, Zhao M, Hou Y, Christian E, Zaghouani S, Wang C, Singh V, Singaraju A, et al.

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IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (326)

Reviews

IL-1 beta/IL-1F2 Protein from R&D Systems, a Bio-Techne Brand

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