Neuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein 396-HB-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemNeuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $415.00Supplier Page View Company Product Page
Catalog Number396-HB-050
SpeciesHuman
Molecule NameNeuregulin-1 beta 1/NRG1 beta 1
Size50 ug (also 200 ug, 1 mg)
Source/Expression SystemE. coli-derived Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein
NCBI Full Gene Nameneuregulin 1
NCBI Gene AliasesGGF2, SMDF, ARIA, NRG1-IT2, HRGA, MST131, HGL, GGF, MSTP131, HRG, NDF, HRG1
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 50 ug (also 200 ug, 1 mg)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Growth factors maintain intratumoral heterogeneity and drive therapeutic resistance in triple-negative breast cancerCell reportsJanuary 27, 2026Devlin KL, Smith R, Bucher E, Dane M, Bowman CL, Carlson EJ, Kilburn D, Sudar D, Feiler HS, Heiser LM, et al.

(2) Immortalization and characterization of Schwann cell lines derived from NF1-associated cutaneous neurofibromasPLOS OneJanuary 21, 2026Hua Li, Alexander Pemov, Robert Allaway, David F. Muir, Lung-Ji Chang, Jineta Banerjee, Alexandra J. Scott, Jaime M.W. Nagy, Jian Liu, Meritxell Carrió, et al.Antibiotic-Antimycotic (Fisher 15240062), 5 µg/ml Plasmocin (Invivogen, ANT-MPP), and 50 ng/µl neuregulin (R&D Systems 396-HB-050). These cultures were expanded and passaged; when cells continued to proliferate beyond the passage

(3) Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapiesMolecular OncologyDecember 23, 2025Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, et al.while the media for IL3‐independent Ba/F3 cells were supplemented or not with neuregulin‐1β (NRG‐1) (396‐HB‐050; R&D Systems, McKinley Place NE, MN, USA). MCF10a cell medium was additionally supplemented with 20

(4) Age-associated G-quadruplex accumulation and DDX5 loss shape chromatin landscapes in human astrocytesResearch squareNovember 19, 2025Tsvetkov A, J VKM, Escarcega RD, Wheeler E, Tandon N, Monchaud D, Hartl C.

(5) The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cellsCell ReportsMarch 25, 2025Michael R. Weaver, Dominika Shkoruta, Marta Pellegatta, Caterina Berti, Marilena Palmisano, Scott Ferguson, Edward Hurley, Julianne French, Shreya Patel, Sophie Belin, et al.penicillin +100 μg/mL streptomycin (Thermo Fisher Scientific 15140–122), 2 ng/mL NRG1 (R&D Systems 396-HB-050), and 2 mM forskolin (EMD Millipore 344270). Primary mouse SCs (mSC) were prepared from pooled sciatic

(6) TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T CellsCancer discoveryJanuary 13, 2025Priego N, de Pablos-Aragoneses A, Perea-García M, Pieri V, Hernández-Oliver C, Álvaro-Espinosa L, Rojas A, Sánchez O, Steindl A, Caleiras E, et al.

(7) ADAM Metallopeptidase domain 19 promotes skin fibrosis in systemic sclerosis via neuregulin-1Molecular MedicineDecember 23, 2024Qiming Meng, Ding Bao, Sijia Liu, Jing Huang, Muyao Guo, Bingying Dai, Liqing Ding, Shasha Xie, Meng Meng, Chunliu Lv, et al.fibroblasts were subjected to a 24 h serum starvation, followed by adding 50 ng/ml recombinant human NRG1 (396-HB-050, R&D Systems, USA) for an additional 24 h. Quantitative real time-PCR Total RNA was extracted utilizing

(8) Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillationNature communicationsNovember 19, 2024Hill MC, Simonson B, Roselli C, Xiao L, Herndon CN, Chaffin M, Mantineo H, Atwa O, Bhasin H, Guedira Y, et al.13256027), 10 ng/mL activin A (R&D Systems, 338-AC-01M), and 10 ng/mL Neuregulin-beta 1 (R&D Systems, 396-HB-050). Cells were incubated at 5% O2 and 10% CO2 at 37 °C. For atrial cardiomyocyte (ACM) differentiation,

(9) Glucoselysine, a unique advanced glycation end-product of the polyol pathway and its association with vascular complications in type 2 diabetesThe Journal of biological chemistryJuly 1, 2024Yamaguchi H, Matsumura T, Sugawa H, Niimi N, Sango K, Nagai R.

(10) TGFβ overcomes FGF-induced transinhibition of EGFR in lens cells to enable fibrotic secondary cataractMolecular Biology of the CellJune 1, 2024Judy K. VanSlyke, Bruce A. Boswell, Linda S. Musildiseases. MATERIALS AND METHODS Materials Recombinant human TGFβ1, TGFα, HB-EGF, NRG1(EGF domain; #396-HB-050), BMP4, and bovine FGF2 were from R & D Systems (Minneapolis, MN). R3IGF-1, an analogue of human IGF1,

(11) A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screeningCell Reports MethodsMay 20, 2024Huyen Thi Lam Nguyen, Emily Kohl, Jessica Bade, Stefan E. Eng, Anela Tosevska, Ahmad Al Shihabi, Peyton J. Tebon, Jenny J. Hong, Sarah Dry, Paul C. Boutros, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, Neuregulin,R&D Systems,CAT#396HB050 rhSCF,STEMCELL Technologies,CAT#78062.1 rhIL-6,STEMCELL Technologies,CAT#78050.1 rhIL-3,STEMCELL Technologies

(12) TGFβ overcomes FGF-induced transinhibition of EGFR in lens cells to enable fibrotic secondary cataractMol Biol CellMay 6, 2024Judy K. VanSlyke, Bruce A. Boswell, Linda S. Musildiseases. MATERIALS AND METHODS Materials Recombinant human TGFβ1, TGFα, HB-EGF, NRG1(EGF domain; #396-HB-050), BMP4, and bovine FGF2 were from R & D Systems (Minneapolis, MN). R3IGF-1, an analogue of human IGF1,

(13) C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosisLife Sci AllianceMarch 8, 2024Melissa R Perrino, Niousha Ahmari, Ashley Hall, Mark Jackson, Youjin Na, Jay Pundavela, Sara Szabo, Trent M Woodruff, Eva Dombi, Mi-Ok Kim, et al.(Cayman Chemical Company), 10 ng/ml recombinant human NRG1-beta 1/HRG1-beta 1 EGF Domain peptide (Cat# 396-HB-050; R&D Systems), and 10% FBS. Schwann cells were labeled with 5 μm of CFSE (BioLegend) at 37°C for 20

(14) Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer's diseaseCell communication and signaling : CCSFebruary 22, 2024Mao R, Hu M, Liu X, Ye L, Xu B, Sun M, Xu S, Shao W, Tan Y, Xu Y, et al.below the skull surface). In detail, recombinant human NRG1-β/HRG1-β1 EGF domain proteins (R&D Systems, 396-HB-050) were reconstituted in sterile PBS containing 1% Bovine serum albumin (BSA). After 30 min of recovery,

(15) Chemokine platelet factor 4 accelerates peripheral nerve regeneration by regulating Schwann cell activation and axon elongationNeural regeneration researchJanuary 1, 2024Gu M, Cheng X, Zhang D, Wu W, Cao Y, He J.

(16) AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cellsCommunications MedicineNovember 28, 2023Yuki Yoshioka, Juliana Bosso Taniguchi, Hidenori Homma, Takuya Tamura, Kyota Fujita, Maiko Inotsume, Kazuhiko Tagawa, Kazuharu Misawa, Naomichi Matsumoto, Masanori Nakagawa, et al.Tocris Bioscience), 20 µM TGF-βinhibitor (SB431542, #13031 Cayman), and 50 ng/mL Neuregulin 1 (NRG1, #396-HB-050 R&D Systems). After 18 days, the medium was changed to Schwann cell differentiation medium containing

(17) HER3 functions as an effective therapeutic target in triple negative breast cancer to potentiate the antitumor activity of gefitinib and paclitaxelCancer cell internationalSeptember 16, 2023Lyu H, Shen F, Ruan S, Tan C, Zhou J, Thor AD, Liu B.

(18) Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell-neuron coculturesJournal of cell scienceSeptember 15, 2023Mutschler C, Fazal SV, Schumacher N, Loreto A, Coleman MP, Arthur-Farraj P.medium Make on day of use.For 50 ml of media: o 50 ml DM (Table S1)o 0.5% HSo 10 ng ml−1 βNRG1 (R&D Systems, 396-HB-050)o 2 μM forskolin (Merck, 344270) or 50-100 μM dibutryl-cAMP (dbcAMP; Merck, D0627). Supplementary Material Click

(19) The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear laminaCell reportsAugust 29, 2023Pruvost M, Patzig J, Yattah C, Selcen I, Hernandez M, Park HJ, Moyon S, Liu S, Morioka MS, Shopland L, et al.

(20) A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cellsStem cell reportsAugust 8, 2023Jovanovic VM, Weber C, Slamecka J, Ryu S, Chu PH, Sen C, Inman J, De Sousa JF, Barnaeva E, Hirst M, et al.

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Neuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein

Neuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein

Neuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein

Neuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein

Neuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein from R&D Systems, a Bio-Techne Brand

Description

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (112)

Reviews

Neuregulin-1 beta 1/NRG1 beta 1 EGF Domain Protein from R&D Systems, a Bio-Techne Brand

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