IL-6R alpha Protein 227-SR-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-6R alpha Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $504.00Supplier Page View Company Product Page
Catalog Number227-SR-025
SpeciesHuman
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Human IL-6R alpha Protein
Molecule NameIL-6R alpha
Size25 ug
NCBI Full Gene Nameinterleukin 6 receptor
NCBI Gene AliasesHIES5, IL6RA, IL6Q, IL6QTL, IL-6RA, gp80, CD126, IL6RQ, IL-6R-1, IL-1Ra, IL-6R
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 45-50 kDa, reducing conditions
Theoretical: 38 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Available conjugates: Sizes Available: 25 ug

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

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(24) Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-AlphaThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 21, 2016König C, Morch E, Eitner A, Möller C, Turnquist B, Schaible HG, Ebersberger A.

(25) Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like ResponsePLoS pathogensJuly 1, 2016Harwardt T, Lukas S, Zenger M, Reitberger T, Danzer D, Übner T, Munday DC, Nevels M, Paulus C.recombinant human IL6 (R&D Systems, 206-IL-010) plus 100 ng/ml recombinant human IL6Rα (R&D Systems, 227-SR-025) for the indicated durations. Fibroblasts are normally unresponsive to IL6, since they have little or

(26) A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant TumorsCancer researchJanuary 15, 2016Zhong H, Davis A, Ouzounova M, Carrasco RA, Chen C, Breen S, Chang YS, Huang J, Liu Z, Yao Y, et al.

(27) Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem CellsStem cells internationalJanuary 1, 2016Bastidas-Coral AP, Bakker AD, Zandieh-Doulabi B, Kleverlaan CJ, Bravenboer N, Forouzanfar T, Klein-Nulend J.

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(29) RelB/p50 complexes regulate cytokine-induced YKL-40 expressionJournal of immunology (Baltimore, Md. : 1950)March 15, 2015Bhardwaj R, Yester JW, Singh SK, Biswas DD, Surace MJ, Waters MR, Hauser KF, Yao Z, Boyce BF, Kordula T.

(30) Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signalingNature chemical biologyJanuary 1, 2015Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP.

(31) Interleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancerPloS oneJanuary 1, 2015Isobe A, Sawada K, Kinose Y, Ohyagi-Hara C, Nakatsuka E, Makino H, Ogura T, Mizuno T, Suzuki N, Morii E, et al.

(32) Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafishJournal of cell scienceJune 15, 2014Bu Y, Su F, Wang X, Gao H, Lei L, Chang N, Wu Q, Hu K, Zhu X, Chang Z, et al.

(33) Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signalingmAbsMay 1, 2014Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S, et al.at room temperature, followed by addition of soluble IL-6 receptor gp80 (R&D Systems, catalog number 227-SR-025) at 125 ng/mL. This complex was then added to prepared HUVEC cells and incubated at 37 °C for 20 min

(35) Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signalingBloodJanuary 30, 2014Csaszar E, Wang W, Usenko T, Qiao W, Delaney C, Bernstein ID, Zandstra PW.

(36) Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastomaClinical cancer research : an official journal of the American Association for Cancer ResearchDecember 1, 2013Zheng Y, McFarland BC, Drygin D, Yu H, Bellis SL, Kim H, Bredel M, Benveniste EN.

(37) NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastomaPloS oneJanuary 1, 2013McFarland BC, Hong SW, Rajbhandari R, Twitty GB Jr, Gray GK, Yu H, Benveniste EN, Nozell SE.