Sonic Hedgehog/Shh (C24II), N-Terminus Protein 1845-SH-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemSonic Hedgehog/Shh (C24II), N-Terminus Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $362.00Supplier Page View Company Product Page
Catalog Number1845-SH-025
SpeciesHuman
Size25 ug (also 100 ug, 500 ug)
Molecule NameSonic Hedgehog/Shh
NCBI Full Gene Namesonic hedgehog signaling molecule
NCBI Gene AliasesHPE3, SMMCI, HHG1, TPT, HLP3, TPTPS, ShhNC, MCOPCB5
FormatLyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug (also 100 ug, 500 ug)

Add to Compare List

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) An in vivo and in vitro spatiotemporal profile of human midbrain developmentNature communicationsFebruary 3, 2026Budinger D, Puigdevall P, Hall GT, Roth C, Xenakis T, Marrosu E, Jerber J, Di Domenico A, Picco F, Kilpinen H, et al.

(2) Proneurogenic Actions of FSH During Directed Differentiation of Neural Stem and Progenitor Cells from Ovarian Cortical Cells Towards the Dopaminergic PathwayBiomedicinesJune 26, 2025Alfredo González-Gil, Concepción Rojo, Esther Ramírez, Ricardo Martín, Alberto Samuel Suárez-Pinilla, Susana Ovalle, Ricardo Ramos-Ruiz, Rosa Ana PicazoThermo Fisher Scientific, ref. 11140050), 1% N2 supplement, 250 ng/mL Sonic Hedgehog (SHH, R&D Systems, ref. 1845-SH-025), 200 ng/mL FGF8 (R&D Systems, ref. 423-F8), 100 ng/mL FGF2, and 10 µL/mL antibiotic–antimycotic. From

(3) Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell linesCell stem cellJune 5, 2025Scuderi S, Kang TY, Jourdon A, Nelson A, Yang L, Wu F, Anderson GM, Mariani J, Tomasini L, Sarangi V, et al.

(4) KEAP1-NRF2/HO-1 Pathway Promotes Ferroptosis and Neuronal Injury in SchizophreniaBrain and behaviorMarch 1, 2025Zhu F, Dan T, Hua S.modulation of the sonic hedgehog (SHH) signaling using recombinant SHH protein (R&D Systems, Cat. #1845‐SH‐025) and activation of the WNT pathway with CHIR99021 (Stem cells, Cat. #99021). Further differentiation

(5) Comprehensive Gene Expression Analysis Using Human Induced Pluripotent Stem Cells Derived from Patients with Sleep Bruxism: A Preliminary In Vitro StudyInternational journal of molecular sciencesDecember 6, 2024Sato T, Yamaguchi A, Onishi M, Abe Y, Shiga T, Ishikawa KI, Baba K, Akamatsu W.

(6) Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease ModelsbioRxiv : the preprint server for biologyDecember 4, 2024Hu R, Boshans LL, Zhu B, Cai P, Tao Y, Youssef M, Girrbach GI, Song Y, Wang X, Tsankov A, et al.

(7) Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiencybioRxiv : the preprint server for biologySeptember 13, 2023Papandreou A, Singh N, Gianfrancesco L, Budinger D, Barwick K, Agrotis A, Luft C, Shao Y, Lenaerts AS, Gregory A, et al.

(8) Inferring and perturbing cell fate regulomes in human brain organoidsNatureSeptember 1, 2023Fleck JS, Jansen SMJ, Wollny D, Zenk F, Seimiya M, Jain A, Okamoto R, Santel M, He Z, Camp JG, et al.

(9) Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastomaResearch squareAugust 3, 2023Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, et al.

(10) Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation modelScientific reportsMay 29, 2023Ito R, Kimura A, Hirose Y, Hatano Y, Mima A, Mae SI, Keidai Y, Nakamura T, Fujikura J, Nishi Y, et al.

(11) Automated high-content imaging in iPSC-derived neuronal progenitorsSLAS discovery : advancing life sciences R & DMarch 1, 2023Papandreou A, Luft C, Barral S, Kriston-Vizi J, Kurian MA, Ketteler R.DMSO,"0,8 μM" Embryoid Body medium(D0-D4),"Sonic Hedgehog C24II, Recombinant modified human [R&D Systems (1845-SH-025)]; stock 25 μg/ml in DPBS, 0.1% BSA",100 ng/ml Embryoid Body medium(D0-D4),"Purmophamine [Cayman Chemicals

(12) Production of parathyroid-like cells from thyroid stem cells in co-culture environmentMedicineDecember 2, 2022Karabiyik Acar Ö, Nozhatzadeh GD, Tuncer A, Torun Köse G, Hacihasanoğlu E, Sahin F, Aysan E.

(13) Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesiseLifeDecember 2, 2022Li X, Gordon PJ, Gaynes JA, Fuller AW, Ringuette R, Santiago CP, Wallace V, Blackshaw S, Li P, Levine EM.reagent,Oligonucleotides,Supplementary file 7,, "Peptide, recombinant protein",Shh-N,R&D Systems,Cat#:1845-SH-025, Commercial assay or kit,Click-iT EdU Alexa Fluor 647 imaging kit,Thermo Fisher Scientific,Cat#:C10340, Commercial

(14) Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cellsMolecular genetics and metabolism reportsJune 1, 2022Hossain MA, Hasegawa-Ogawa M, Manome Y, Igarashi M, Wu C, Suzuki K, Igarashi J, Iwamoto T, Okano HJ, Eto Y.

(15) Parkinson's Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1CellsMay 16, 2022Tan JSY, Lee B, Lim J, Ma DR, Goh JX, Goh SY, Gulam MY, Koh SM, Lee WW, Feng L, et al.

(16) LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neuronsAutophagyMay 1, 2022Burbidge K, Rademacher DJ, Mattick J, Zack S, Grillini A, Bousset L, Kwon O, Kubicki K, Simon A, Melki R, et al.containing LDN, SB, recombinant human SHH (sonic hedgehog signaling molecule; 100 pg/µl; R&D Systems, 1845-SH-025), purmorphamine (2 µM; ReproCell, 04–0009) and recombinant human FGF8 (fibroblast growth factor 8; 100

(17) Sonic hedgehog is Essential for Proximal-Distal Outgrowth of the Limb Bud in SalamandersFrontiers in Cell and Developmental BiologyApril 1, 2022Sruthi Purushothaman, Brianda B. Lopez Aviña, Ashley W. SeifertPFA, washed with 1× PBS, and imaged under a stereoscope microscope. SHH-N protein (R&D Systems, cat#1845-SH-025) was reconstituted in 1× PBS with 0.1% BSA. Each Affi-bead (Affi-Gel Blue Media, cat#153-7301, 150–300

(18) Suspension culture promotes serosal mesothelial development in human intestinal organoidsCell reportsFebruary 15, 2022Capeling MM, Huang S, Childs CJ, Wu JH, Tsai YH, Wu A, Garg N, Holloway EM, Sundaram N, Bouffi C, et al.

(19) Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic TanycytesFrontiers in neuroscienceJanuary 1, 2022Moore A, Chinnaiya K, Kim DW, Brown S, Stewart I, Robins S, Dowsett GKC, Muir C, Travaglio M, Lewis JE, et al.

(20) Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem CellsStem cells internationalJanuary 1, 2022Lee DS, Song YJ, Gug HR, Lee JH, Bae HS, Park JC.

Be the First to Write a Review!

Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus

Sonic Hedgehog/Shh (C24II), N-Terminus Protein

Sonic Hedgehog/Shh (C24II), N-Terminus Protein

Sonic Hedgehog/Shh (C24II), N-Terminus Protein

Sonic Hedgehog/Shh (C24II), N-Terminus Protein

Sonic Hedgehog/Shh (C24II), N-Terminus Protein from R&D Systems, a Bio-Techne Brand

Description

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (82)

Reviews

Sonic Hedgehog/Shh (C24II), N-Terminus Protein from R&D Systems, a Bio-Techne Brand

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map