Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF 1875-CD-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $465.00Supplier Page View Company Product Page
Catalog Number1875-CD-050
SpeciesHuman
Molecule NameFc gamma RIIB/C (CD32b/c)
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size50 ug
NCBI Full Gene NameFc gamma receptor IIc (gene/pseudogene), Fc gamma receptor IIb
NCBI Gene AliasesFCRIIC, FcgammaRIIb, FcGRIIB, CD32C, CD32, FCGR2C, FcgammaRIIc, CD32B, FCGR2, IGFR2, FcRII-c, FCG2, CDW32
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 25-35 kDa, reducing conditions
Theoretical: 21 kDa
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platformDrug DelivMay 26, 2025Barnabas Nyesiga, Karin Hägerbrand, Laura Varas, Anette Gjörloff Wingren, Mats Ohlin, Peter Ellmark, Laura von Schantz(1257-FC, R&D Systems), FcγRIIa-H167 (9595-CD, R&D Systems), FcγRIIa-R167 (1330-CD, R&D Systems), FcγRIIb (1875-CD-050, R&D Systems), FcγRIIIa-V176 (4325-FC-050, R&D Systems), FcγRIIIa F176 (8894-FC-050, R&D Systems), or

(2) Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancybioRxiv : the preprint server for biologyMay 2, 2023Adhikari EH, Lu P, Kang YJ, McDonald AR, Pruszynski JE, Bates TA, McBride SK, Trank-Greene M, Tafesse FG, Lu LL.

(3) BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with ageCell reportsOctober 25, 2022Bates TA, Lu P, Kang YJ, Schoen D, Thornton M, McBride SK, Park C, Kim D, Messer WB, Curlin ME, et al.

(4) Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodiesJCI insightOctober 10, 2022Rogel A, Ibrahim FM, Thirdborough SM, Renart-Depontieu F, Birts CN, Buchan SL, Preville X, King EV, Al-Shamkhani A.

(5) Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergyNature communicationsSeptember 27, 2022An SB, Yang BG, Jang G, Kim DY, Kim J, Oh SM, Oh N, Lee S, Moon JY, Kim JA, et al.

(6) BNT162b2 induced neutralizing and non-neutralizing antibody functions against SARSCoV-2 diminish with agemedRxiv : the preprint server for health sciencesAugust 16, 2022Bates TA, Lu P, Kang YJ, Schoen D, Thornton M, McBride SK, Park C, Kim D, Messer WB, Curlin ME, et al.

(7) Discovery of a novel Igβ and FcγRIIB cross-linking antibody, ASP2713, and its potential application in the treatment of systemic lupus erythematosusInternational immunopharmacologyDecember 1, 2021Kitanaga Y, Yamajuku D, Kubo S, Nakamura K, Maeda M, Seki M, Kaneko Y, Kinugasa F, Morokata T, Kondo Y, et al.

(8) Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malariaeLifeJune 29, 2021Aitken EH, Damelang T, Ortega-Pajares A, Alemu A, Hasang W, Dini S, Unger HW, Ome-Kaius M, Nielsen MA, Salanti A, et al.

(9) High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2European journal of immunologyJune 1, 2021Vanhove B, Duvaux O, Rousse J, Royer PJ, Evanno G, Ciron C, Lheriteau E, Vacher L, Gervois N, Oger R, et al.

(10) Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus MacaquesFrontiers in ImmunologyMarch 16, 2021Nuria Pedreño-Lopez et al.concentration of each isotype, or PE-conjugated FcγRIIa, FcγRIIb, and FcγRIIIa (R&D Systems, #1330-CD-050, #1875-CD-050, #4325-FC-050, respectively). The plates were incubated for 1 h at room temperature on a shaker. Next,

(11) An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancerEMBO molecular medicineFebruary 5, 2021Zekri L, Vogt F, Osburg L, Müller S, Kauer J, Manz T, Pflügler M, Maurer A, Heitmann JS, Hagelstein I, et al.

(12) Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal modelsmAbsJanuary 1, 2021Kumar S, Ghosh S, Sharma G, Wang Z, Kehry MR, Marino MH, Neben TY, Lu S, Luo S, Roberts S, et al.calculated. Binding of dostarlimab to FcγRI (Cat#1257-FC-050), FcγRIIa (Cat#9595-CD-050), FcγRIIb (Cat#1875-CD-050), FcγRIIIa (Cat#4325-FC-050), and FcγRIIIb (Cat#1597-FC-050; all from R&D Systems) was assessed by SPR

(13) Pharmacologic Characterization of ALD403, a Potent Neutralizing Humanized Monoclonal Antibody Against the Calcitonin Gene-Related PeptideJournal of Pharmacology and Experimental TherapeuticsJuly 1, 2020Leon F. Garcia-Martinez et al.receptors [FcgRI/CD64, cat. no. 1257-FC-050; FcgRIIA/CD32a, cat. no. 1330CD-050; FcgRIIB/C (CD32b/c), cat. no. 1875-CD-050; FcgRIIIA/ CD16a, cat. no. 4325-FC-050; FcgRIIIB/CD16b, cat. no. 1597-fc-050/ CF; R&D Systems, Minneapolis,

(14) Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor BindingStructureMay 1, 2020Chiara Orlandi, Daniel Deredge, Krishanu Ray, Neelakshi Gohain, William Tolbert, Anthony L. DeVico, Patrick Wintrode, Marzena Pazgier, George K. LewisIIA/CD32a,R&D systems,Cat# 1330-CD-050 Human Recombinant FcγR receptor IIB/CD32b,R&D systems,Cat# 1875-CD-050 Human Recombinant FcγR receptor IIIA/CD16a,R&D systems,Cat# 4325-FC-050 Horseradish peroxidase conjugated

(15) Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza VirusJournal of immunology (Baltimore, Md. : 1950)March 1, 2019Blundell PA, Lu D, Wilkinson M, Dell A, Haslam S, Pleass RJ.

(16) IgG3 regulates tissue-like memory B cells in HIV-infected individualsNature immunologySeptember 1, 2018Kardava L, Sohn H, Youn C, Austin JW, Wang W, Buckner CM, Justement JS, Melson VA, Roth GE, Hand MA, et al.consisted of monoclonal recombinant IgG3 (Bio-Rad; clone ABD18705), recombinant CD32b/c (R&D Systems; Cat# 1875-CD-050), and plasma-derived IgM (Abcam; Cat# ab91117). SDS-PAGE and immunoblot analysis. Protein purity and

(17) Extending human IgG half-life using structure-guided designmAbsJuly 26, 2018Brian J. Booth, Boopathy Ramakrishnan, Kristin Narayan, Andrew M. Wollacott, Gregory J. Babcock, Zachary Shriver, Karthik ViswanathanFcγ receptors I, IIa, IIb, IIIa V176, and IIIa F176 (R&D Systems catalog # 1257-FC-050, 1330-CD-050, 1875-CD-050, 4325-FC-050, and 8894-FC-050, respectively) was measured by ELISA. All Fc variants were tested in the

(18) Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumabmAbsMay 1, 2018Seo N, Polozova A, Zhang M, Yates Z, Cao S, Li H, Kuhns S, Maher G, McBride HJ, Liu J.

(19) Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 AntibodiesCancer cellApril 9, 2018Arce Vargas F, Furness AJS, Litchfield K, Joshi K, Rosenthal R, Ghorani E, Solomon I, Lesko MH, Ruef N, Roddie C, et al.

(20) FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibodymAbsApril 1, 2018Zhang D, Whitaker B, Derebe MG, Chiu ML.

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Fc gamma RIIB/C (CD32b/c) Protein

Fc gamma RIIB/C (CD32b/c) Protein

Fc gamma RIIB/C (CD32b/c) Protein

Fc gamma RIIB/C (CD32b/c) Protein

Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF from R&D Systems, a Bio-Techne Brand

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