Fig 1: Artemin-induced cold allodynia is insensitive to inhibition of either CGRP, substance P, or TLR4 signaling.(A) Model for neurogenically induced cold allodynia (Image generated in BioRender). Wildtype mice pretreated with CGRP8–37 (B), SR140333 (C), or TAK242 (D) show robust cold allodynia after an intraplantar injection of artemin (nsp>0.05, ****p<0.0001, one-way ANOVA with Tukey’s multiple comparisons test for BL, antagonist, and antagonist+ARTN, unpaired t-test with Welch’s correction for agonist+ARTN versus veh+ARTN).
Supplier Page from R&D Systems, a Bio-Techne Brand for Recombinant Mouse Artemin Protein, CF