PD-L2/B7-DC Fc Chimera Protein 1022-PL-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemPD-L2/B7-DC Fc Chimera Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $465.00Supplier Page View Company Product Page
Catalog Number1022-PL-100
SpeciesMouse
Molecule NamePD-L2/B7-DC
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size100 ug (also 1 mg)
NCBI Full Gene Nameprogrammed cell death 1 ligand 2
NCBI Gene AliasesB7DC, bA574F11.2, PDL2, F730015O22Rik, PD-L2, CD273, Btdc, PDCD1L2, B7-DC
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 76 kDa, reducing conditions
Theoretical: 49 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 100 ug (also 1 mg)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stabilityNature communicationsAugust 31, 2022Hurrell BP, Helou DG, Howard E, Painter JD, Shafiei-Jahani P, Sharpe AH, Akbari O.

(2) Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancermAbsJanuary 1, 2021Schofield DJ, Percival-Alwyn J, Rytelewski M, Hood J, Rothstein R, Wetzel L, McGlinchey K, Adjei G, Watkins A, Machiesky L, et al.PD-L1 Fc chimera and recombinant mouse PD-L2 Fc chimera (R&D Systems, catalog nos. 1019-B7-100 and 1022-PL-100). Conjugations with europium cryptate trisbipyridine–N-hydroxysuccinimide (Cisbio) were performed according

(3) Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and AutoimmunityCell reportsSeptember 24, 2019Garo LP, Ajay AK, Fujiwara M, Beynon V, Kuhn C, Gabriely G, Sadhukan S, Raheja R, Rubino S, Weiner HL, et al.Chimera Protein, CF",R&D systems,Cat#1019-B7–100 "Mouse PDL2-Fc Chimera Protein, CF",R&D systems,Cat#1022-PL-100 GM-CSF,R&D systems,Cat#415-ML-010 IL-4,R&D systems,Cat#404-ML-010 TGF-β,R&D systems,Cat#240-B-002 Chemicals

(4) RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory toleranceThe Journal of experimental medicineMay 5, 2014Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, et al.

(5) Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responsesImmunityJuly 1, 2007Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ.

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PD-L2/B7-DC Fc Chimera Protein

PD-L2/B7-DC Fc Chimera Protein

PD-L2/B7-DC Fc Chimera Protein

PD-L2/B7-DC Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (5)

Reviews

PD-L2/B7-DC Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

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