Epiregulin Protein 1195-EP-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemEpiregulin Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $423.00Supplier Page View Company Product Page
Catalog Number1195-EP-025/CF
SpeciesHuman
Size25 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
Molecule NameEpiregulin
NCBI Full Gene Nameepiregulin
NCBI Gene AliasesEPR, Ep, ER
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human Epiregulin Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Mapping mesenchymal diversity in the developing human intestine and organoidsbioRxivJuly 25, 2025Kelli F. Johnson, Xiangning Dong, Yu-Hwai Tsai, Angeline Wu, Sydney G. Clark, Sha Huang, Rachel K. Zwick, Ian Glass, Katherine D. Walton, Ophir D. Klein, et al.factor (EGF) (100 ng/mL R&D Systems Cat#236-EG-01M) or Epiregulin (EREG) (10 ng/mL R&D Systems Cat#1195-EP-025/CF) with Noggin-Fc (100ng/mL, purified from conditioned media), and R-Spondin1 (5% conditioned medium)

(2) Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculatureCell Stem CellApril 3, 2025Charlie J. Childs, Holly M. Poling, Kevin Chen, Yu-Hwai Tsai, Angeline Wu, Abigail Vallie, Madeline K. Eiken, Sha Huang, Caden W. Sweet, Ryan Schreiner, et al.ng/mL R&D Systems Cat#236-EG-01M) or Epiregulin (EREG) (100 ng/mL, 10 ng/mL, 1 ng/mL R&D Systems Cat#1195-EP-025/CF) with Noggin-Fc (100ng/mL, purified from conditioned media35), and R-Spondin1 (5% conditioned medium36)

(3) Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal CancerCancer ResMarch 3, 2025Joan Jacob, Yasuaki Anami, Peyton C. High, Zhengdong Liang, Shraddha Subramanian, Sukhen C. Ghosh, Solmaz AghaAmiri, Cara Guernsey-Biddle, Ha Tran, Julie Rowe, et al.Cell Signaling Technology and anti-Myc-Cy3 (Sigma-Aldrich Cat# C6594 RRID:AB_258958, 1:1000). Recombinant hEREG (Cat# 1195EP025CF) was from R&D Systems. Antibody production MAb production was performed by transiently expressing

(4) Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal CancerCancer ResearchMarch 3, 2025Joan Jacob, Yasuaki Anami, Peyton C. High, Zhengdong Liang, Shraddha Subramanian, Sukhen C. Ghosh, Solmaz AghaAmiri, Cara Guernsey-Biddle, Ha Tran, Julie Rowe, et al.Cell Signaling Technology and anti-Myc-Cy3 (Sigma-Aldrich Cat# C6594 RRID:AB_258958, 1:1000). Recombinant hEREG (Cat# 1195EP025CF) was from R&D Systems. Antibody production MAb production was performed by transiently expressing

(5) Transcriptomic analysis of EGFR co-expression and activation in glioblastoma reveals associations with its ligandsNeuro-Oncology AdvancesFebruary 17, 2025Santoesha A Ghisai, Nastaran Barin, Levi van Hijfte, Kim Verhagen, Maurice de Wit, Martin J van den Bent, Youri Hoogstrate, Pim J FrenchFisher Scientific), BTC (Betacellulin human, B3670, Sigma-Aldrich), EREG (Recombinant Human Epiregulin Protein, 1195-EP-025/CF, R&D Systems), or PBS as negative control. Cells were fixed with paraformaldehyde (PFA) solution (4%,

(6) Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand bindingNature communicationsNovember 21, 2023Wirth D, Özdemir E, Hristova K.ligands used in this study were EGF (8916sf, Cell Signaling), TGFα (239A100, R&D Systems), Epiregulin (1195EP025 CF, R&D Systems), and EGF-tetramethylrhodamine (E3481, Thermofisher). For the transducer function measurements,

(7) Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growthDisease models & mechanismsApril 1, 2023Lemmetyinen TT, Viitala EW, Wartiovaara L, Kaprio T, Hagström J, Haglund C, Katajisto P, Wang TC, Domènech-Moreno E, Ollila S.

(8) Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in ObesityCellsJanuary 26, 2022Song NJ, Lee A, Yasmeen R, Shen Q, Yang K, Kumar SB, Muhanna D, Arnipalli S, Noria SF, Needleman BJ, et al.

(9) Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-RasBiochemical and biophysical research communicationsDecember 10, 2020Lee SW, Commisso C.and SCH772985 (Cat. No. S7101) were obtained from Selleck Chemical. Human epiregulin (EREG) (Cat. No. 1195-EP-025/CF) was obtained from R&D Systems. Bafilomycin (Cat. No. NC0910155) was obtained from Cayman Chemical.

(10) EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapyTheranosticsJanuary 1, 2020Liu S, Wang Y, Han Y, Xia W, Zhang L, Xu S, Ju H, Zhang X, Ren G, Liu L, et al.

(11) EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced MacropinocytosisDevelopmental CellAugust 1, 2019Szu-Wei Lee, Yijuan Zhang, Michael Jung, Nathalia Cruz, Basheer Alas, Cosimo Commisso(MTT),Sigma-Aldrich,Cat#M5655 Human HB-EGF,Sigma-Aldrich,Cat#SRP3052 Human epiregulin (EREG),R&D Systems,Cat#1195-EP-025/CF Human amphiregulin (AREG),R&D Systems,Cat#262-AR-100/CF DQ red BSA,Thermo Fisher Scientific,Cat#D12051 Human

(12) Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signalingBiochemical and biophysical research communicationsJuly 15, 2017Iijima M, Anai M, Kodama T, Shibasaki Y.

(13) Gene expression analysis of pig cumulus-oocyte complexes stimulated in vitro with follicle stimulating hormone or epidermal growth factor-like peptidesReproductive biology and endocrinology : RB&EOctober 6, 2015Blaha M, Nemcova L, Kepkova KV, Vodicka P, Prochazka R.

(14) Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survivalMolecular cancerJuly 29, 2015Farooqui M, Bohrer LR, Brady NJ, Chuntova P, Kemp SE, Wardwell CT, Nelson AC, Schwertfeger KL.For treatment of cells with EREG, cells were treated with 10 ng/ml recombinant human EREG (rhEREG) (1195-EP-025/CF; R&D Systems, Minneapolis, MN). For inhibitor studies, cells were treated with the indicated amounts

(15) High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptorBMC cancerDecember 13, 2013Auf G, Jabouille A, Delugin M, Guérit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, et al.

(16) Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factorDevelopment (Cambridge, England)February 1, 2006Armant DR, Kilburn BA, Petkova A, Edwin SS, Duniec-Dmuchowski ZM, Edwards HJ, Romero R, Leach RE.

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Recombinant Human Epiregulin Protein, CF

Epiregulin Protein

Epiregulin Protein

Epiregulin Protein

Epiregulin Protein

Epiregulin Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Epiregulin Protein from R&D Systems, a Bio-Techne Brand

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