TWEAK/TNFSF12 Protein 1090-TW-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemTWEAK/TNFSF12 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $449.00Supplier Page View Company Product Page
Catalog Number1090-TW-025
SpeciesHuman
Source/Expression SystemE. coli-derived Recombinant Human TWEAK/TNFSF12 Protein
Size25 ug
Molecule NameTWEAK/TNFSF12
NCBI Full Gene NameTNF superfamily member 12
NCBI Gene AliasesTWEAK, APO3L, TNLG4A, DR3LG
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight18.3 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Epigenetic context defines the transcriptional activity of canonical and noncanonical NF-κB signaling in pancreatic cancerCell Death DiscoveryMarch 17, 2026Joana E. Aggrey-Fynn, Joshua Busch, Dominik Saul, Ashish Rajput, Kerstin Willecke, Meghana Manjunath, Nicole Klimt, Kothai Rajendran, Nadine Schacherer, Wanwan Ge, et al.Table S1. Cells were treated with TNF (10 ng/ml; R&D systems 210-TA-100), TWEAK (10 ng/ml; R&D systems 1090-TW-025), caspase 3/7 (1:500; ThermoFisher; C10432), and cycloheximide (10 µM; Sigma Aldrich; C7698). Protein

(2) Eupatolide, isolated from Liriodendron tulipifera, sensitizes TNF-mediated dual modes of apoptosis and necroptosis by disrupting RIPK1 ubiquitinationHeliyonMarch 30, 2024Kyeong Ah Park, Chan Seok Jung, Kyung-Cheol Sohn, Eunjin Ju, Sanghee Shin, InWha Park, MinKyun Na, Gang Min Hurwere from Enzo Life Science (Ann Arbor, MI, USA); recombinant TNF‐α (410‐MT), LIGHT (664‐LI), TWEAK (1090-TW-025) were from R&D system (Minneapolis, MN, USA); pan‐caspase inhibitor (z‐VAD‐fmk) (218759), necrostatin‐1

(3) NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibitionMolecular metabolismDecember 1, 2022Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, et al.

(4) Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activityEMBO molecular medicineOctober 10, 2022Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, et al.

(5) Evaluation of Computationally Designed Peptides against TWEAK, a Cytokine of the Tumour Necrosis Factor Ligand FamilyInternational journal of molecular sciencesJanuary 21, 2021Badia-Villanueva M, Defaus S, Foj R, Andreu D, Oliva B, Sierra A, Fernandez-Fuentes N.

(6) Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of ApoptosisMediators of inflammationJanuary 1, 2019Wang X, Cheng D, Hu G, Liang L, Tan F, Xiao T, Xiao S, Xia Y.

(7) An anti-TL1A antibody for the treatment of asthma and inflammatory bowel diseasemAbsMay 1, 2018Clarke AW, Poulton L, Shim D, Mabon D, Butt D, Pollard M, Pande V, Husten J, Lyons J, Tian C, et al.

(8) Involvement of TWEAK and the NF-κB signaling pathway in lupus nephritisExperimental and therapeutic medicineMarch 1, 2018Sun F, Teng J, Yu P, Li W, Chang J, Xu H.consent prior to study commencement. Reagents and materials. Recombinant human TWEAK cytokine (cat. no. 1090‑TW‑025) and goat anti‑human TWEAK antibody (cat. no. AF1199‑SP) were purchased from R&D Systems, Inc. (Minneapolis,

(9) NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosusNature communicationsJanuary 12, 2018Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, et al.

(10) Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblastsPloS oneJanuary 1, 2018Lee SJ, Kim J, Ko J, Lee EJ, Koh HJ, Yoon JS.

(11) TWEAK/Fn14 promotes pro-inflammatory cytokine secretion in hepatic stellate cells via NF-κB/STAT3 pathwaysMolecular immunologyJuly 1, 2017Wang A, Zhang F, Xu H, Xu M, Cao Y, Wang C, Xu Y, Su M, Zhang M, Zhuge Y.

(12) TWEAK mediates inflammation in experimental atopic dermatitis and psoriasisNature communicationsMay 22, 2017Sidler D, Wu P, Herro R, Claus M, Wolf D, Kawakami Y, Kawakami T, Burkly L, Croft M.

(13) Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6The Journal of biological chemistryMay 19, 2017Yamaguchi N, Nakayama Y, Yamaguchi N.

(14) Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in miceCell death & diseaseJanuary 5, 2017Guicciardi ME, Krishnan A, Bronk SF, Hirsova P, Griffith TS, Gores GJ.

(15) Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Activates Type I Interferon Signals in Lupus NephritisBioMed research internationalJanuary 1, 2017Xue L, Liu L, Huang J, Wen J, Yang R, Bo L, Tang M, Zhang Y, Liu Z.

(16) Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-κB/MMP9 PathwayPloS oneJanuary 1, 2016Xu M, Zhang F, Wang A, Wang C, Cao Y, Zhang M, Zhang M, Su M, Zou X, Xu G, et al.

(17) Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradationThe Journal of biological chemistryMay 9, 2014Gurunathan S, Winkles JA, Ghosh S, Hayden MS.

(18) The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatmentThe Journal of investigative dermatologyApril 1, 2013Zhou H, Ekmekcioglu S, Marks JW, Mohamedali KA, Asrani K, Phillips KK, Brown SA, Cheng E, Weiss MB, Hittelman WN, et al.

(19) Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasionJournal of cell scienceOctober 1, 2012Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.

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Recombinant Human TWEAK/TNFSF12 Protein

TWEAK/TNFSF12 Protein

TWEAK/TNFSF12 Protein

TWEAK/TNFSF12 Protein

TWEAK/TNFSF12 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Reviews

TWEAK/TNFSF12 Protein from R&D Systems, a Bio-Techne Brand

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