Fig 1: Differential pSTAT3 stimulation and IL-22 receptor genes expression across species. (A) pSTAT3 stimulation dose curves in response to recombinant IL-22 (rIL-22) in mouse, rat, monkey, and human primary hepatocytes. Species-specific rIL-22 was used for rat and mouse hepatocytes. rhIL-22 was used for monkey and human hepatocytes. For rat, there was no signal, so no value is shown in the graph (A). Average FPKM expression of IL-22-receptor genes (IL10Rβ, IL-22RA1, and IL-22RA2) in Liver (B) and Skin (C) for mouse, rat, monkey, and human. Additional details on this case example are summarized in Table 4.