Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF 1129-ER-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human ErbB2/Her2 Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $445.00Supplier Page View Company Product Page
Catalog Number1129-ER-050
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size50 ug (also 1 mg)
Molecule NameErbB2/Her2
NCBI Full Gene Nameerb-b2 receptor tyrosine kinase 2
NCBI Gene Aliasesc-ERB-2, NGL, MLN-19, CD340, VSCN2, TKR1, HER-2, p185(erbB2), HER2, NEU, HER-2/neu, MLN 19, c-ERB2
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 125-130 kDa, reducing conditions 220-250 kDa, non-reducing conditions
Theoretical: 96.8 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Microfluidic Nanosensor for Label-Free Multiplexed Detection of Breast Cancer Biomarkers via Surface-Enhanced Reflective FTIR Spectroscopy Using Thin Gold Films and Antibody-Oriented Gold Nanourchin: Feasibility StudyMicromachines (Basel)November 11, 2025Mohammad E. Khosroshahi, Gayathri Senthilchelvan, Victor Oyebolustandard solutions (i.e., pure) were purchased from (Lee Biosolutions, Maryland Heights, MO, USA) and (1129-ER-050, R&D Systems, Minneapolis, MN, USA), respectively. Serum samples from breast cancer (BCS) patients with

(2) Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applicationsJ NanobiotechnologyOctober 4, 2025Feng Chen, Michelle S. Bradburymonospecific DARPin constructs. Recombinant human HER2 ectodomain (residues 23–652, Fc chimera; cat# 1129-ER-050, R&D Systems/Novus), expressed in CHO cells, and full-length human VEGF165 (cat# VEG-HM065, KACTUS),

(3) Dual-Oriented Targeted Nanostructured SERS Label-Free Immunosensor for Detection, Quantification, and Analysis of Breast Cancer Biomarker Concentrations in Blood SerumBiosensorsJuly 11, 2025Khosroshahi ME, Gaoiran C, Umashanker V, Veeru H, Panday P.the experiment. HER-II and CA15-3 standard solutions (i.e., pure) were purchased from R&D Systems (1129-ER-050, Minnesota, USA) and Lee Biosolutions (Missouri, USA), respectively. Serum samples from breast cancer

(4) DAP12-associated synthetic antigen receptors enable multi-targeting of T cells with independent chimeric receptors in a small genetic payloadiScienceApril 18, 2025Allyson E. Moore, Hayley Nault, Derek Cummings, Bonnie Bojovic, Nick Serniuck, Christopher L. Baker, Craig Aarts, Chitra Venugopal, Sheila K. Singh, Joanne A. Hammill, et al.R3189L XbaI,NewEngland Biolabs (NEB),Cat# R0145L Recombinant Human ErbB2/Her2 Fc Chimera Protein,R&D Systems,Cat# 1129-ER-050 Recombinant human IL-2,PeproTech,Cat# 200-02 Recombinant human IL-7,PeproTech,Cat# 200-07 ImmunoCult™ Human CD3/CD28/CD2 T Cell Activator

(5) A checkpoint reversal receptor mediates bipartite activation and enhances CAR T-cell functionCancer Research CommunicationsMarch 1, 2025Daniel Landi, Shoba A. Navai, Rebecca M. Brock, Kristen Fousek, Zeid Nawas, Khaled Sanber, Cynthia Chauvin-Fleurence, Raksha R. Bhat, Shuo Xu, Purna Krishnamurthy, et al.expression, T cells were incubated with recombinant human HER2-Fc chimera protein (5 μL; R&D Systems, 1129-ER-050) followed by staining with goat anti-human IgG Fc PE (1 μL; Thermo Fisher Scientific, 12-4998, RRID:

(6) Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cellsScience advancesJanuary 10, 2025Gad AZ, Morris JS, Godret-Miertschin L, Montalvo MJ, Kerr SS, Berger H, Lee JCH, Saadeldin AM, Abu-Arja MH, Xu S, et al.

(7) A dual-luciferase bioluminescence system for the assessment of cellular therapiesMolecular Therapy: OncologyMarch 21, 2024Alejandro G. Torres Chavez, Mary K. McKenna, Kishore Balasubramanian, Lisa Riffle, Nimit L. Patel, Joseph D. Kalen, Brad St. Croix, Ann M. Leen, Pradip Bajgain109-606-097). HER2 CAR was detected using a chimeric Erb2-Fc fusion protein (R&D Systems, catalog no. 1129-ER-050) with Alexa Fluor 647 anti-Fc antibody (Southern Biotech, Birmingham, AL, catalog no. 2014-31). Cells

(8) Inosine induces stemness features in CAR-T cells and enhances potencyCancer cellFebruary 12, 2024Klysz DD, Fowler C, Malipatlolla M, Stuani L, Freitas KA, Chen Y, Meier S, Daniel B, Sandor K, Xu P, et al.M.D. Anderson Cancer,N/A human Her2-Fc recombinant proteins (Dylight650 labelled),R&D Systems,Cat#1129-ER-050 Human CD95-BV421 (clone DX2),BioLegend,Cat#305624; RRID: AB_2561830 human CD4-APC-Cy7 (clone OKT4),BioLegend,Cat#317418 human

(9) Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycinProtein expression and purificationFebruary 1, 2024Sakata J, Tatsumi T, Sugiyama A, Shimizu A, Inagaki Y, Katoh H, Yamashita T, Takahashi K, Aki S, Kaneko Y, et al.

(10) CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Receptors and Early Activation of CAR T CellsCancersJune 7, 2023Mezősi-Csaplár M, Szöőr Á, Vereb G.confirm HER2-CAR expression, indirect labeling was carried out with a HER2-Fc fusion protein (Cat.# 1129-ER-050, R&D Systems, Minneapolis, MN, USA) and Alexa Fluor 488-conjugated anti-human IgG (Cat.# A-11013, Invitrogen

(11) Enhancement of in vivo targeting properties of ErbB2 aptamer by chemical modificationPloS oneJanuary 1, 2023Park JY, Cho YL, Chae JR, Lee JH, Kang WJ.

(12) The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine KinasesInternational journal of molecular sciencesJuly 31, 2022Poźniak M, Żukowska D, Gędaj A, Krzyścik MA, Porębska N, Zakrzewska M, Otlewski J, Opaliński Ł.

(13) CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cellsNature communicationsJanuary 31, 2022Hebbar N, Epperly R, Vaidya A, Thanekar U, Moore SE, Umeda M, Ma J, Patil SL, Langfitt D, Huang S, et al.

(14) Production of human CAR-NK cells with lentiviral vectors and functional assessment in vitroSTAR protocolsDecember 17, 2021Portillo AL, Hogg R, Ashkar AA.Recombinant Human IL-2,PeproTech,Cat#200-02; Accession# P60568 Recombinant Human ErbB2/Her2 Fc Chimera Protein,R&D Systems,Cat#1129-ER-050; Accession# NP_004439 Hexadimethrine bromide (Polybrene),Sigma-Aldrich,Ca# H9268; CAS: 28728-55-4 5(6)-Carboxyfluorescein

(15) The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell TumorigenesisCancersNovember 16, 2021Stoup N, Liberelle M, Schulz C, Cavdarli S, Vasseur R, Magnez R, Lahdaoui F, Skrypek N, Peretti F, Frénois F, et al.

(16) Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity ProteinPharmaceuticsNovember 3, 2021Garousi J, Ding H, von Witting E, Xu T, Vorobyeva A, Oroujeni M, Orlova A, Hober S, Gräslund T, Tolmachev V.

(17) Bioproduced Proteins On Demand (Bio-POD) in hydrogels using Pichia pastorisBioactive materialsAugust 1, 2021Yuan SF, Brooks SM, Nguyen AW, Lin WL, Johnston TG, Maynard JA, Nelson A, Alper HS.

(18) A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathyEMBO molecular medicineJuly 7, 2021Chidiac R, Abedin M, Macleod G, Yang A, Thibeault PE, Blazer LL, Adams JJ, Zhang L, Roehrich H, Jo HN, et al.(1617‐FZ‐050), FZD7 (6178‐FZ‐050), FZD8 (6129‐FZ‐050), FZD9 (9175‐FZ‐050), FZD10 (3459‐FZ‐050), Her2 (1129‐ER‐050), and histidine‐tagged fusion proteins of mouse LRP5 (7344‐LR‐025/CF) and mouse LRP6 (2960‐LR‐025) were

(19) Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumorsiScienceJune 25, 2021Portillo AL, Hogg R, Poznanski SM, Rojas EA, Cashell NJ, Hammill JA, Chew MV, Shenouda MM, Ritchie TM, Cao QT, et al.,R&D Systems,Cat#240-B-002; Accession# P01137 Recombinant Human ErbB2/Her2 Fc Chimera Protein,R&D Systems,Cat#1129-ER-050; Accession# NP_004439 Prostaglandin E2,Sigma-Aldrich,Cat#P0409; CAS: 363-24-6 Recombinant Human IL-7,Peprotech,Cat#200-07;

(20) A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinomaScience Translational MedicineMay 5, 2021Vanaja Konduri, Sujith K. Joseph, Tiara T. Byrd, Zeid Nawas, Jonathan Vazquez-Perez, Colby J. Hofferek, Matthew M. Halpert, Dongliang Liu, Zhengdong Liang, Yunyu Baig, et al.30–60 minutes at 4° C with recombinant human HER2 Fc chimera protein (3 μl @ 0.1 μg/μl, R&D systems 1129-ER-050) and then stained with goat anti-human IgG1 Fc-PE (0.5 μl, eBioscience 12–4998-82), anti-human CD161-APC

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ErbB2/Her2 Fc Chimera Protein

ErbB2/Her2 Fc Chimera Protein

ErbB2/Her2 Fc Chimera Protein

ErbB2/Her2 Fc Chimera Protein

ErbB2/Her2 Fc Chimera Protein

Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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