Recombinant Human PDGF R beta Fc Chimera Protein, CF 385-PR-100/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human PDGF R beta Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $491.00Supplier Page View Company Product Page
Catalog Number385-PR-100/CF
SpeciesHuman
Molecule NamePDGF R beta
Size100 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
NCBI Full Gene Nameplatelet derived growth factor receptor beta
NCBI Gene AliasesIBGC4, PDGFR, PDGFR-1, KOGS, CD140B, PENTT, IMF1, PDGFR1, JTK12
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 94-124 kDa, reducing conditions
Theoretical: 84 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human PDGF R beta Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβEJNMMI Radiopharmacy and ChemistryMarch 16, 2026Ayman Abouzayed, Hugo Olsson, Natalia Papadopoulos, Bogdan Mitran, Hemantha Mallapura, Tahmida Akter, Irina Velikyan, Olle Korsgren, Carl-Henrik Heldin, John Löfblom, et al.cat.no. 29149603) were immobilized with carrier-free recombinant human PDGFRβ-Fc (R&D Systems, cat.no. 385-PR-100/CF) dissolved in pH 5.0 sodium acetate at 25 μg/mL concentration. Using an NHS chemistry-based coupling

(2) Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adultsBrain Imaging and BehaviorSeptember 10, 2024Joey A. Contreras, Kimiko Fujisaki, Nancy E. Ortega, Giuseppe Barisano, Abhay Sagare, Ioannis Pappas, Helena Chui, John M. Ringman, Elizabeth B. Joe, Berislav V. Zlokovic, et al.sPDGFRβ in human CSF (ng/mL). Standard curves were generated using recombinant human PDGFRβ (Cat. No. 385-PR-100/CF, R&D Systems, Minneapolis, MN) (as described in Nation et al., 2019). MRI data acquisition, preprocessing

(3) Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adultsResearch squareMarch 7, 2023Contreras JA, Fujisaki K, Ortega N, Barisano G, Sagare A, Pappas I, Chui H, Ringman JM, Joe EB, Zlokovic B, et al.sPDGFRβ in human CSF (ng/mL). Standard curves were generated using recombinant human PDGFRβ (Cat. No. 385-PR-100/CF, R&D Systems, Minneapolis, MN) (as described in Nation et al., 2019). MRI Data Acquisition, Preprocessing

(4) Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogenHeadacheMarch 1, 2021Cowan RP, Gross NB, Sweeney MD, Sagare AP, Montagne A, Arakaki X, Fonteh AN, Zlokovic BV, Pogoda JM, Harrington MG.reported. 26 , 27 Briefly, CSF samples and recombinant human PDGFRβ carrier‐free protein (Cat. No. 385‐PR‐100/CF, R&D Systems) were subjected to 4–12% Bis‐Tris SDS/PAGE gel electrophoresis (Thermo Scientific) for

(5) DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneouslyNature communicationsJanuary 29, 2021Beckmann R, Jensen K, Fenn S, Speck J, Krause K, Meier A, Röth M, Fauser S, Kimbung R, Logan DT, et al.

(6) Associations between Vascular Function and Tau PET Are Associated with Global Cognition and AmyloidThe Journal of neuroscience : the official journal of the Society for NeuroscienceOctober 28, 2020Albrecht D, Isenberg AL, Stradford J, Monreal T, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, Chui H, et al.2015; Nation et al., 2019). Briefly, CSF samples and recombinant human PDGFR b carrier-free protein (catalog #385-PR-100/CF, R&D Systems) were subjected to 4–12% Bis-Tris SDS/PAGE (Thermo Fisher Scientific) for 2 h at 150 V

(7) Engineered receptors for human cytomegalovirus that are orthogonal to normal human biologyPLoS pathogensJune 1, 2020Park J, Gill KS, Aghajani AA, Heredia JD, Choi H, Oberstein A, Procko E.

(8) Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunctionNature medicineFebruary 1, 2019Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, et al.as we previously reported8. Standard curves were generated using recombinant human PDGFRβ (Cat. No. 385-PR-100/CF, R&D Systems, Minneapolis, MN). Astrocyte marker CSF levels of the astrocytic cytokine, S100B, were

(9) Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK DynamicsScientific reportsNovember 27, 2017Mamer SB, Chen S, Weddell JC, Palasz A, Wittenkeller A, Kumar M, Imoukhuede PI.VEGFR3 (Cat. #349-F4–050, R&D Systems), PDGFRα (Cat #322-PR-050/CF, R&D Systems) and PDGFRβ (Cat. #385-PR-100/CF, R&D Systems) were immobilized on flow cells by first performing pre-concentration studies to determine

(10) A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sectionsNucleic acids researchJune 20, 2017Lykkemark S, Mandrup OA, Jensen MB, Just J, Kristensen P.

(11) A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cellsPLoS pathogensApril 1, 2017Stegmann C, Hochdorfer D, Lieber D, Subramanian N, Stöhr D, Laib Sampaio K, Sinzger C.

(12) Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entryPLoS pathogensApril 1, 2017Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, Wildner S, Scrivano L, Adler B.

(13) Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degenerationmAbsFebruary 1, 2017Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris MC, Clabbers A, Dong F, Shen J, Hackett SF, et al.

(14) Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the in vivo Antitumor Effects of Human TRAILTheranosticsJanuary 1, 2017Tao Z, Yang H, Shi Q, Fan Q, Wan L, Lu X.

(15) Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamerMolecular therapy : the journal of the American Society of Gene TherapyApril 1, 2014Camorani S, Esposito CL, Rienzo A, Catuogno S, Iaboni M, Condorelli G, de Franciscis V, Cerchia L.

(16) Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic painPloS oneJanuary 1, 2014Donica CL, Cui Y, Shi S, Gutstein HB.

(17) Vascular endothelial growth factor signals through platelet-derived growth factor receptor β in meningiomas in vitroBritish journal of cancerNovember 6, 2012Pfister C, Pfrommer H, Tatagiba MS, Roser F.

(18) Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor releaseJ PeriodontolOctober 1, 2003Lacoste E, Martineau I, Gagnon G.

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Recombinant Human PDGF R beta Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human PDGF R beta Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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