Fig 1: The processed BMP‐10 CPLX binds robustly to BMP receptors whereas the unprocessed dimer shows no receptor interaction. Sensorgrams of SPR interaction studies of soluble BMP‐10 GF, processed BMP‐10 CPLX, and unprocessed BMP‐10 dimer flowed over immobilized BMP receptors. Soluble analytes were injected onto immobilized BMPRII, ALK‐1, and ENG at concentrations ranging from 0 to 80 nM. K D s were calculated from three independent experiments (N = 3).