IL-21 Protein 594-ML-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-21 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $417.00Supplier Page View Company Product Page
Catalog Number594-ML-010
SpeciesMouse
Molecule NameIL-21
Size10 ug (also 25 ug, 100 ug)
NCBI Full Gene Nameinterleukin 21
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight14.4 kDa
NCBI Gene AliasesZa11, IL-21, CVID11
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Mouse IL-21 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 10 ug (also 25 ug, 100 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Potent antitumor activity of a designed interleukin-21 mimicbioRxiv : the preprint server for biologyDecember 7, 2024Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, et al.

(2) IL-21 Shapes the B Cell Response in a Context-Dependent MannerbioRxiv : the preprint server for biologyJuly 13, 2024Kim Y, Manara F, Grassmann S, Belcheva KT, Reyes K, Kim H, Downs-Canner S, Yewdell WT, Sun JC, Chaudhuri J.

(3) RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in micePLoS pathogensJuly 1, 2024Cheng Q, Yang X, Zou T, Sun L, Zhang X, Deng L, Wu M, Gai W, Jiang H, Guo T, et al.

(4) CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responsesNature communicationsJanuary 29, 2024Scherlinger M, Li H, Pan W, Li W, Karino K, Vichos T, Boulougoura A, Yoshida N, Tsokos MG, Tsokos GC.

(5) The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiationCell discoveryAugust 1, 2023Gu W, Zhang J, Li Q, Zhang Y, Lin X, Wu B, Yin Q, Sun J, Lu Y, Sun X, et al.

(6) CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4(+) T cellsCellular & molecular immunologyJuly 1, 2023Hao Y, Miraghazadeh B, Chand R, Davies AR, Cardinez C, Kwong K, Downes MB, Sweet RA, Cañete PF, D'Orsogna LJ, et al.plate-coated anti-CD3 antibody (2 µg/ml; BD, 553058), B cells (4T: 1B), IL-21 (20 ng/ml; R&D Systems, 594-ML-010) and IL-2 (5 ng/ml; Miltenyi Biotec, 130-120-662) for 5 days. All mouse experiments and procedures were

(7) Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiomeEBioMedicineJune 1, 2023Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, Gulko PS.

(8) The RNA-binding protein hnRNP F is required for the germinal center B cell responseNature communicationsMarch 30, 2023Huang H, Li Y, Zhang G, Ruan GX, Zhu Z, Chen W, Zou J, Zhang R, Wang J, Ouyang Y, et al.

(9) Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8(+) T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen StimulationInternational journal of molecular sciencesNovember 16, 2022Quenum AJI, Santharam MA, Ramanathan S, Ilangumaran S.

(10) Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor EffectsCancer immunology researchJuly 1, 2022Mary R, Chalmin F, Accogli T, Bruchard M, Hibos C, Melin J, Truntzer C, Limagne E, Derangère V, Thibaudin M, et al.

(11) The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21Nature communicationsDecember 9, 2021Zotos D, Quast I, Li-Wai-Suen CSN, McKenzie CI, Robinson MJ, Kan A, Smyth GK, Hodgkin PD, Tarlinton DM.

(12) Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 CellsScientific reportsJune 1, 2021Singh A, Dashynam M, Chim B, Escobar TM, Liu X, Hu X, Patnaik S, Xu X, Southall N, Marugan J, et al.

(13) Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model miceJournal of pharmacological sciencesDecember 1, 2019Matsuda M, Doi K, Tsutsumi T, Inaba M, Hamaguchi J, Terada T, Kawata R, Kitatani K, Nabe T.

(14) Distinct Requirements of CHD4 during B Cell Development and Antibody ResponseCell reportsApril 30, 2019Yen WF, Sharma R, Cols M, Lau CM, Chaudhry A, Chowdhury P, Yewdell WT, Vaidyanathan B, Sun A, Coffre M, et al.

(15) IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid ModelCellular and molecular gastroenterology and hepatologyJanuary 1, 2019Zwarycz B, Gracz AD, Rivera KR, Williamson IA, Samsa LA, Starmer J, Daniele MA, Salter-Cid L, Zhao Q, Magness ST.

(16) Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriersTheranosticsJanuary 1, 2019Yang X, Zhao J, Duan S, Hou X, Li X, Hu Z, Tang Z, Mo F, Lu X.

(17) REV-ERBα Regulates T_H17 Cell Development and AutoimmunityCell reportsDecember 26, 2018Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, Pelletier OB, He Y, et al.

(18) Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infectionPLoS pathogensNovember 1, 2018Cheng Q, Liu J, Pei Y, Zhang Y, Zhou D, Pan W, Zhang J.

(19) Characterization and allergic role of IL-33-induced neutrophil polarizationCellular & molecular immunologyAugust 1, 2018Sun B, Zhu L, Tao Y, Sun HX, Li Y, Wang P, Hou Y, Zhao Y, Zhang X, Zhang L, et al.

(20) LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma CellsImmunityJuly 17, 2018Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, et al.protein,R&D Systems GmbH,Cat. #406-ML-005 Recombinant murine IL-21 protein,R&D Systems GmbH,Cat. #594-ML-010 MultiScreenHTS IP Filter Plate,Millipore,Cat. #MSIPN4510 BCIP/NBT substrate,Thermo Fisher Scientific,Cat.

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Recombinant Mouse IL-21 Protein

IL-21 Protein

IL-21 Protein

IL-21 Protein

IL-21 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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IL-21 Protein from R&D Systems, a Bio-Techne Brand

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